Objective To study the efficacy of insulin pump therapy for type 2 diabetes and its impact on quality of life.Methods 60 patients with type 2 diabetes were selected and divided into A group and B group according to a random number table,30 cases in each group.The patients of B group were given conventional therapy,and which of A group was treated with insulin pump.The fasting plasma glucose,0.5h fasting blood glucose and 2h postprandial blood glucose were measured and compared before and after treatment,the quality of life was evaluated by quality of life scale(QOL),the QOL score before and after treatment between two groups was compared.Results The fasting plasma glucose,0.5h fasting blood glucose and 2h postprandial blood glucose of A group after treatment were (5.69 ±0.19)mmol/L,(5.28 ± 1.03) mmol/L and (7.31 ±2.14) mmol/L,respectively,which were significantly lower than (6.72 ± 2.04) mmol/L,(6.39 ± 1.69) mmol/L and (9.72 ± 1.57) mmol/L of B group (t =9.798,10.023,9.971,P =0.035,0.027,0.032) ; The QOL score of the group A was (78.4 ± 0.8) points,which was significantly better than that before treatment (t =9.064,P =0.023),and better than that of group B (t =10.853,P =0.019).Conclusion Insulin pump has better clinical efficacy in the treatment of type 2 diabetes compared with conventional therapy,it can effectively control blood sugar and improve the quality of life of patients.

Objective To analyze the onset, clinical manifestation, causation, complications of pediatric uveitis. MethodsOne hundred and two patients with uveitis under 16 year-old were retrospectively studied. They visited the clinic in Peking University First Hospital from November 1979 to December 2008. Their age ranged from 2.5 to 16 years old, with a mcan of 11.9 years. Routine exam was carried out, including visual acuity, slit lamp, fundus, and laboratory workup. The diagnosis and classification were made by the anatomic location according to the standard of The International Uveitis Working Group. The data of disease history, age of onset, manifestation, recurrence, causation, systemic diseases, complications, and lab examination were analyzed. Results A total of 102 patients (170 eyes)with pediatric uveitis were included in this study, 68 patients (66.6%) were bilateral cases. Anterior uveitis represented in 38 patients (37.3% ), intermediate uveitis in 19 (18.6%), posterior uveitis in 10 (9.8%),and panuveitis in 35 (34.3%). The disease duration was from five days to 2.4 years, with a mean of 3.6 months. The follow-up time was two weeks to more than ten years. The first three causes of pediatric uveitis were juvenile idiopathic arthritis, Vogt-Koyanagi Harada disease, and Behcet's disease. 36 patients were found with complications, and among them 19 had complicated cataract, seven had secondary glaucoma, five had corneal band dystrophy, 12 had iris synechia (both anterior and posterior), one had retinal detachment, two had eye atrophy, and one patient with juvenile idiopathic arthritis had bilateral femoral head necrosis because of the use of steroid and hip joint was replaced. There were ten children suffering more than two complications. Conclusions Pediatric uveitis is a possible blindness disease with variety of etiology and manifestations, and tends to cause complications. Early and special attention must be taken to avoid serious consequences.

Objective To analyses the effect of Buzhong Yiqi Decoction on the expression of Caspase-3 in human lung adenocarcinoma cells (A 549) tumor-bearing mice’spleen. Method 24 BALB/c mice were randomly divided into the control group(given saline),low-dose and high-dose Buzhong Yiqi Decoction groups,cisplatin(DDP)group;Buzhong Yiqi Decoction was administered twice daily for 10 days consecutively and DDP was administered once daily for 3 days consecutively, after 15 days was the spleens of all tumor-bearing mice were obtained.The expression of Caspase-3 protein and Caspase-3 mRNA in every group were detected by immunohistochemical method seperately and polymerase chain reaction method seperately. Results Compared with control group,the result of immunohistochemistry showed that the expression of the Caspase-3 protein in Buzhong Yiqi Decoction low-dose group and high-dose group were both ssignificantly increased (P<0.05). The differences hetween DDP group and control group was not significant, but the differences between DDP sroup and Buzhong Yigi Decoction Low-dose sroup and hishdoe group were significant (P<0.05, P<0.01).The result of RFPCR was accordance with the result of immunohisto chemistry. Conclusion Buzhong Yiqi Decoction can increase the expression of Caspase-3 protein in A549 ctumor-bearing mice’spleen,and promote the Caspase-3’s inducing effect on tumor cell apoptosis.

Objective To investigate the relationship between concurrent mental disorders and original respiratory diseases.Methods 35 cases diagnosed as severe respiratory diseases accompanied by various mental disorders from July 2005 to December 2008 were analyzed with the clinical presentation,examination,diagnosis and treatment.Results After the treatments of the original respiratory diseases and the necessary psychiatric drugs,the original respiratory diseases relieved and the symptoms of mental disorders disappeared.Conclusion Much more attention should be paid to concurrent mental disorders of respiratory diseases,and the timely treatments of symptoms of mental disorders will be of benefit to the therapy of original diseases.

OBJECTIVE To approach pathogens and precaution strategy of nosocomial pneumonia in patients with myasthenia gravis.METHODS Forty cases of myasthenia gravis from Jan 2003 to Dec 2006 in a certain hospital were involved in the retrospective review.Patients with myasthenia gravis and nosocomial pneumonia were selected out in accordance with diagnostic criteria of nosocomial pneumonia.Risk factors and pathogens of infection were analyzed.Precaution strategy was formulated.RESULTS There were 26 patients with nosocomial pneumonia among 40 cases of myasthenia gravis.Pathogens isolated from sputum culture were all drug resistant strains.Gram-negative bacteria such as Klebsiella pneumoniae,Pseudomonas aeruginosa,Escherichia coli,etc were the most,accounted for 51.85%(84 strains).The next was Gram-positive bacteria,accounted for 33.33%(54 strains).Fungi ranked the third,accounted for 14.81%(24 strains).CONCLUSIONS Precaution and cure measurement should be adopted to prevent and control the occurrence of nosocomial pneumonia in patients with myasthenia gravis.

Objective To investigate the present mental disability situation in Hubei provinee and the reha- bilitation strategies in use. Methods Provincial data from the Second China Sampling Survey of Disability was ana- lyzed. The 31 districts sampled in the survey were divided into a city group and a countryside group. The incidence of mental disability reported in the two groups was compared. Results Reported mental disability was found to be sig- nifieantly more prevalent in the countryside than in the city. However, the proportion of severe mental disability was significantly lower. Conclusion The need for rehabilitation of mental disability is huge in Hubei province. Society and the government should pay more attention to the rehabilitation of mental disability.

To evaluate the effect of endoscopic ultrasonography guided celiac plexus neurolysis (EUS CPN) on pain associated with pancreatic carcinoma. Methods EUS CPN was performed to relieve pain in 16 patients with advanced pancreatic carcinoma. By EUS, we used fine needle to puncture at the region of celiac ganglion and inject alcohol. The pain tensions were followed up under visual analogue scale rule at 2 days and weekly thereafter. Results All patients were performed EUS CPN successfully. No serious complications happened. No satisfactory pain control after the first 2 days of EUS CPN.Whereas it was relieved obviously after 7 days and the effects maintain a rather long term. Conclusion EUS CPN is a safe and effective method for releiving the pain in pancreatic carcinoma.

0.05). Conclusion There are MA and mutation of p53 gene in T-cell lymphoma though no significant correlation between them. But, MA positive cases might experience high mutation of p53 gene in T-cell lymphoma.

Objective To observe the effects of Lentinan(LNT) combined with Cisplatin (DDP) on the apoptosis induction in mice bearing Lewis lung carcinomas (LLC). Methods Lewis lung carcinoma cells (1?107) were subcutaneously inoculated into BALB/c mice. Mice were randomized into control groups and treatment groups. Observe the morphologic views under light microscope (LM) and electron microscope (EM). Results Compared with the control groups, the treatment groups were morphologic characteristic by relatively smaller in size, cell atypia were not evident, pathalogical karyokinesis were less interstitial blood vessel were fewer, while lymphocyte infiltrate into the interstitial. Apoptotic bodies could be seen under EM. Within all treatment groups, LNT+DDP group showed significant difference. Conclusions Lentinan combined with Cisplatin showed significant antitumor effects, and mechanism maybe inducing the tumor cell apoptosis and stimulate the proliferation of lymphocyte.

Objective To observe the effect of Hydroxycamptothecin (HCPT) on proliferation of human lung cancer cell line A549 in vitro. Method Using cell calture and MTT assay to observe the effect of HCPT on proliferation of human lung cancer cell line A549. Result Lower concentration of HCPT had no evident inhibitory effect on the human lung cancer cell line A549 after 24 h. The effect was evident when the concentration of HCPT was up to 50 ?g/mL, and the inhibitory rate was 44.17%. The inhibitory rate was 50.28% when the concentration of HCPT was up to 100 ?g/mL. The inhibitory effect of HCPT became more significant with the stimulation of the time, and the inhibitory rate of 100 ?g/mL concentration of HCPT was 70.98% after 48 h. Conclusions HCPT can inhibit the proliferation of human lung cancer cell A549 in vitro. The effect is dose and time dependent.