1.Scoring methods for liver tissue fibrosis based on ultrasound radio frequency time series.
Yongzhen GAO ; Chunyi LIN ; Qiubin CHEN ; Jianhua ZHOU
Journal of Biomedical Engineering 2015;32(1):175-180
Trying to provide ultrasonic image-aid measures for quantitative diagnosis and dynamic monitoring of liver fibrosis, we propose two scoring methods for liver fibrosis tissue in vivo , based on ultrasound radio frequency (RF) time series in this paper. Firstly, RF echo signals of human liver were recorded in this study. Then one of the recorded frame RF data was demodulated to be B model image. After that, a region of interest (ROI) in the B model image was selected. For each point in the ROI, its all frame data were acquired so that RF time series were formed. An SMR (size measure relationship) fractal dimension and six spectral features were extracted from RF time series in the ROI. With relative deviation and Fisher's discriminant ratio, seven features were weighted and summed so that the liver tissues' scores were obtained, Score-rd and Score-fisher, respectively. Area under ROC curve (AUC) and a support vector machine (SVM) were used to evaluate whether these scoring methods would be useful in distinguishing normal and cirrhosis tissues. Experimental results are shown as follows: Score-rd's AUC was 0.843, while Score-fisher was 0.816, SVM classification accuracies were both up to 87.5%. This proved that our proposed scoring methods were effective in distinguishing normal and cirrhosis tissues. Score-rd and Score-fisher have potential for clinical applications. They can also provide quantitative references for liver fibrosis diagnosis.
Area Under Curve
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Fractals
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Humans
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Liver Cirrhosis
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classification
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diagnostic imaging
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Radio Waves
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Support Vector Machine
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Ultrasonography
2.Study on correlation between homocysteine and diabetes mellitus
Shaorong LIN ; Chunyi ZHEN ; Longfeng CHEN ; Manna CHEN ; Rong ZHOU
International Journal of Laboratory Medicine 2015;(13):1866-1867
Objective To explore the correlation between homocysteine(Hcy),lipids amd type 2 diabetes mellitus (T2DM). Methods The laboratory test results of 533 cases of patients with T2DM(T2DM group)and 362 cases of healthy individuals (healthy control group)were retrospectively analyzed.Results The serum levels of Hcy and rates of abnormal serum cholesterol (TC),triacylglycerol(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)levels in the T2DM group were higher than those in the healthy control group,had statistically significant differences(P <0.05).Conclusion The high serum level of Hcy and abnormal lipid metabolism are correlated with T2DM,which might be risk factors of diabetes mel-litus and cardiovascular disease.
3.The literature review of women′s decison on mode of delivery and its related factors
Chunyi GU ; Qiping LIN ; Chunxiang ZHU ; Lei SHU
Chinese Journal of Practical Nursing 2017;33(22):1757-1760
Decision on mode of delivery (MOD) is a process involved by both clients and health care providers, based on specific clinical situations and women′s values. To help each woman obtain the best MOD is crucial for obstetric health professionals to provide women-centered high quality of care. There is a steep upward trend in cesarean sections in China due to the introduced advanced technologies, overused antenatal monitoring methods, flexible indications for cesarean sections, delayed childbearing ages and people′s misconceptions, etc.. Recently the conditional and comprehensive two-child policy have been implemented in China, which might initiate changes in fertility and birth intentions of many families, and in subsequent decisions on MOD. This review illustrates the pros and cons of MOD, decision process on MOD, influencing factors and strategies to promote decision on MOD, in order for the obstetric professionals to provide evidence-based best care for women and their families in the process of decision-making.
4.A medical image semantic modeling based on hierarchical Bayesian networks.
Chunyi LIN ; Lihong MA ; Junxun YIN ; Jianyu CHEN
Journal of Biomedical Engineering 2009;26(2):400-404
A semantic modeling approach for medical image semantic retrieval based on hierarchical Bayesian networks was proposed, in allusion to characters of medical images. It used GMM (Gaussian mixture models) to map low-level image features into object semantics with probabilities, then it captured high-level semantics through fusing these object semantics using a Bayesian network, so that it built a multi-layer medical image semantic model, aiming to enable automatic image annotation and semantic retrieval by using various keywords at different semantic levels. As for the validity of this method, we have built a multi-level semantic model from a small set of astrocytoma MRI (magnetic resonance imaging) samples, in order to extract semantics of astrocytoma in malignant degree. Experiment results show that this is a superior approach.
Artificial Intelligence
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Astrocytoma
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diagnosis
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Bayes Theorem
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Brain Neoplasms
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diagnosis
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Diagnostic Imaging
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methods
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Humans
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Image Interpretation, Computer-Assisted
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methods
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Image Processing, Computer-Assisted
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methods
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Magnetic Resonance Imaging
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Models, Theoretical
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Semantics
5. Left atrial appendage volume is a valuable predictor of atrial fibrillation recurrence after radiofrequency catheter ablation
Gui′an ZHENG ; Chunyi LIN ; Lan WENG ; Jiandong CHEN
Chinese Journal of Cardiology 2017;45(11):924-929
Objective:
To investigate the association between the left atrial appendage (LAA) volume and atrial fibrillation (AF) recurrence after radiofrequency catheter ablation.
Methods:
We prospectively enrolled sixty-two patients with AF (40 cases with paroxysmal AF, 22 cases with persistent AF) who successfully underwent a first AF catheter ablation and had performed contrast-enhanced cardiac computed tomography (CT) prior to the procedure to measure LAA volumes in our hospital from January 2012 to August 2015. Circumferential pulmonary vein isolation was performed under the guidance of three-dimension mapping system (CARTO system). Linear ablation or ablation of complex fractioned atrial electrograms was also undertaken if necessary. All patients were followed up at the 3rd, 6th and 12th months after ablation by 24-hour ambulatory Holter monitoring, and were divided into the non-recurrence group (
6.Visual analysis of occupational health and safety research among medical staff
Yilian HUANG ; Xinxiang QIU ; Lin XU ; Lüqin WEN ; Chunyi TANG ; Yan ZENG ; Xiangnen ZENG
China Occupational Medicine 2023;50(2):165-169
7. Efficacy and safety of oseltamivir in children with suspected influenza: a multicenter randomized open-label trial
Chunhui HE ; Chunyi LIU ; Guangyu LIN ; Qian PENG ; Jiayi LIAO ; Junhong LIN ; Tao ZHANG ; Xuefang ZHENG ; Chuangxing LIN ; Shijun WANG ; Rongshan CHEN ; Li DENG ; Yuming CHEN
Chinese Journal of Pediatrics 2017;55(6):462-467
Objective:
To evaluate the efficacy and safety of oseltamivir in the treatment of suspected influenza in children.
Method:
A multicenter, randomized and open-label trial was conducted among 229 individuals with suspected influenza which were collected from the clinic of 5 hospitals in Guangdong province (Guangzhou Women and Children′s Medical Center, Shenzhen Baoan District Maternity and Child Care Service Center, the Second Affiliated Hospital of Shantou University Medical College, Dongguan Maternity and Child Care Service Centre, Yuexiu District Children′s Hospital of Guangzhou) from April to July 2015. They were randomized either to oseltamivir group (oseltamivir 30-75 mg, twice daily for 5 days) or control group who were given symptom relief medicines for 5 days.
Result:
No significant difference was found between two groups in influenza symptoms of the patients before the treatment(
8. Comprehensive analysis of unplanned abdominal - pelvic reoperations in Peking University Cancer Hospital and Institute from 2008 to 2018
Dan WANG ; Zhouqiao WU ; Wei WANG ; Xiaoyi WANG ; Jing LIU ; Chunyi HAO ; Ziyu LI ; Dong XUE ; Lin SHEN ; Jiafu JI
Chinese Journal of Gastrointestinal Surgery 2019;22(9):869-875
Objective:
To summarize the characteristics of abdominal-pelvic unplanned reoperation (URO) in a cancer hospital.
Methods:
Retrospectively descriptive cohort research was adopted. The classification of diseases was based on ICD-10, and surgical classification was based on ICD-9-CM-3. Medical record summary database from 2008 to 2018 in Beijing Cancer Hospital was collected, and all URO information of abdominal-pelvic surgery was retrieve. The time of URO, disease type, surgery type and cause were statistically analyzed. Distribution of main disease incidence and constituent ratio, and the application of major surgery and surgery type composition ratio were analyzed as well.
Results:
From 2008 to 2018, a total of 46854 cases underwent abdominal-pelvic surgery (including gastrointestinal, hepatic-biliary-pancreatic, gynecological, urological, or esophageal cancer surgery) and 713 patients received URO (1.52%), including 486 males and 227 females (2.14:1.00) with a mean age of (58.1±12.2) years. A total of 246 patients (34.50%) had comorbidity, and with comorbidity: without comorbidity was 1.13:1.00. The hospital stay was (44.5±43.0) days, and the total cost was (178000±112000) yuan. There were 22 deaths (3.09%). The median interval between URO and the first operation was 8 (0 to 131) days. The highest rate of URO was 2.45% (89/3629) in 2012, while the lowest was 0.95% (53/5596) in 2015. The top 3 major cancer types of URO included colorectal cancer (222 cases, 31.14%), gastric cancer (166 cases, 23.28%) and esophageal cancer (45 cases, 6.31%). The cancer types with the highest URO rate included pancreatic cancer (3.97%, 30/756), gastric cancer (1.81%, 166/9171) and colorectal cancer (1.80%, 222/12333). The top 3 surgical procedures resulting in URO were rectal resection (109 cases, 15.29%), total gastrectomy (79 cases, 11.08%), and total pancreatectomy (64 cases, 8.98%). Focusing on 497 URO cases from 2012 to 2018, 465 cases (93.56%) followed relatively difficult grade III and IV surgery, while only 32 cases (6.44%) followed grade I and II surgery. The top 5 main causes of URO were bleeding (225 cases, 31.56%), anastomotic leak (225 cases, 31.56%), infection (89 cases, 12.48%), intestinal obstruction (53 cases, 7.43%), and wound dehiscence (35 cases, 4.91%), adding up to a total of 87.94% of all URO.
Conclusion
This study summarizes the epidemiology of abdominal - pelvic URO in our cancer institution, providing the solid baseline for future investigation of URO and the subsequent formulation of corresponding prevention and intervention measures.