Objective To determine the influence of general anesthesia on postoperative cognitive function in patients undergoing noncardiac surgery. Methods Forty ASA Ⅰ -Ⅱ patients aged 50-70 years undergoing elective noncardiac surgery under general anesthesia ( n = 20) or general anesthesia combined with epidural block (n =20) were studied.Patients with psychiatrical or neurological disorders or taking hyponotics regularly were excluded.General anesthesia was induced with propofol 1.5-2.5mg/kg and fentanyl 2?g/kg.Tracheal or bronchial intubation was facilitated with vecuronium 0.6mg/kg.The patients were then mechanically ventilated and PETCO2 was maintained at 30-40mm Hg. Anesthesia was maintained with 1.0%-2.0% isoflurane and intermittent iv boluses of vecuronium. Epidural catheter was inserted at T8.9 and a mixture of 0.33% poutocaine and 2%lidocaine was infused through catheter at a rate of 4-6ml/h by using Graseby 3500 infusion pump.Radial artery was cannulated for intra-arterial pressure monitoring. ECG, PETCO2 and end-tidal-isoflurane concentration were monitored during operation. Whenever BP was

Tumor necrosis factor-related apoptosis-inducing ligand(TRAIL) is a recently identified cytokine of apoptosis that selectively induces the apoptosis of various tumor cells but not normal cells.The members of this family known to date are TRAIL and its five related receptors.TRAIL and its receptors are expressed in ovarian malignant tumor cells and can induce their apoptosis.Many chemotherapeutic agents can enhance TRAIL-induced apoptosis of malignant tumor cells,so TRAIL-induced cytotoxicity holds a powerful promise in the fight against ovarian malignant tumor.