The toxic Chinese materia medicia (CMM) has been considered as the combination of active ingredients and toxic ingredients. After reviewing on the theory of traditional Chinese medicine (TCM),combined with clinical and experimental researches,it was found that the two kinds of ingredients have dialectical relationship,they were manifested with "double-side" or "multi-surface" ,even could change into each other. Based on the above understanding,the new research mehods were proposed as follows:Evaluating toxicity of toxic CMM under the physiological and pathological states; Establishing its drug-nature and toxicity under the different pathological states; Focusing on different pathological states to establish the best combination of active and toxic ingredients; Exploring the transitional mechanism of the active and toxic ingredients.

Objective To study the ultrasonic features of fetus deformity.Methods 34 cases with fetus defomity were examined by Aloka 280 B-mode ultrasound and Hp-image point system(3.5 MHz transducer).Results Of the thirty-four cases with fetus deformity,thirty-one cases were seen and proved by the clinical induced labour and parturition.Only three of the cases were misdiangnosed.Conclusion Examination with the ultrasonic equipment is a simple and convenient way in the antenantal examination.Fetus deformity often exists simultaneously with various types of deformity and has close relationship with the amount of amniatic fluid.

This study was aimed to observe the effect of Pediatric Long-term Cough Decoction in the treatment of long-term cough among children. A total of 96 cases were diagnosed in traditional Chinese medicine (TCM) as qi-yin deficiency, and lung-heat accumulation with constipation. The western medicine diagnosis was mycoplasma pneumoniae pneumonia (MPP) infection in the recovery period after chronic cough. All cases were randomly divided into the TCM group and control group, with 48 cases in each group. In TCM group, the Pediatric Long-term Cough Decoction was used to supplement qi and nourish yin, clear away the lung-heat and excrete feces. In the control group, montelukast was used. For both groups, clinical effect of score and CD4+ T lymphocytes, CD8+ T lymphocytes and CD4+/CD8+ ratio were observed one day before treatment and thirty days after treatment. The results showed that after thirty-day treatment, the clinical effect of score in both groups was obviously improved (P < 0.01). The TCM group was better than the control group (P< 0.01). Compared with pretreatment, the posttreatment CD4+ T lympho-cytes, CD8+ T lymphocytes and CD4+/CD8+ ratio in TCM group were obviously improved (P < 0.05). The CD4+ T lymphocytes and CD4+/CD8+ ratio in the control group were obviously improved (P < 0.05). However, there was no change on the CD8+ T lymphocytes. The regulation effect on CD4+ T lymphocytes and CD8+ T lymphocytes of TCM group was better than the control group (P< 0.01). It was concluded that the Pediatric Long-term Cough Decoction can effectively improve clinical symptoms of chronic cough in children and regulate immune function.

Objective:To determine the relationship between brachia l artery blood pressure and radial artery blood pressure in children and whether blood pressure measured from the radial artery can replace blood pr essure measured from the brachial artery. Methods:Brachial and rad ial artery pressures in 105 children were measured using an electronic sphygmomanometer.Results:There was no significant difference between the average values of blood pressures of the brachial and radial arteries in the 105 children studied (P>0.05). Linear regression and correlation analyses showed that there was a positive linear correlation between the systolic pressure of the b rach ial artery and the radial artery in the 105 children, as well as a posit ive linear correlation between the diastolic pressures of the brachial and the radial arteries. Conclusion:Blood pressure values from the radial artery can completely replace blood pressure values from the brachial artery.

The main pathological change of Alzheimer’s disease (AD) was the formation of senile plaques (SP) induced by the abnormal accumulation ofβ-amyloid protein (Aβ). Blood-brain barrier (BBB) can regulate the Aβ metabolism in the brain through relevant transporter to complete the across BBB transport. This paper introduced two main transporters, which were the receptor for advanced glycation end products (RAGE) and the low density lipoprotein receptor-related protein-1 (LRP-1) in BBB for the elucidation of neuronal cell toxicity induced by inflammatory factors from Aβ accumulation within the brain. It further explored the regulation on two transport proteins, which were RAGE and LRP-1 in BBB for the reduction of abnormal accumulation of Aβ, relieving of inflammation in the brain, and protection of cerebral neurons by traditional Chinese medicine (TCM).

Based on the accurate cognition about tumor pathology,relying on observation of clinic cases,combining unsettled problems about tumor,instructed by theory of pathogenesis,the project puts forward the cancerous toxin-rooted and rising and falling of vital qi and pathogen-determined tumor viewpoint.The purpose of this paper is to provide methods and theory for treatment of tumor.

AIM: To study the blood quickening and stasis dispelling effect of the different processed products of Rhizoma Curcumae by rat's platelet aggregation in vivo and its hemorrheological properties and blood coagulation. METHODS: The platelet aggregation determination, hemorrheological properties determination and mice blood coagulation method were used to observe the blood quickening and stasis dispelling effect of the different processed products of Rhizoma Curcumae. RESULTS: The different processed products of Rhizoma Curcumae all had some inhibition on platelet aggregation, anticoagulation and improvement on the hemorrheological parameters. Among all of them, the processed product with vinegar was the most strong. CONCLUSION: In traditional processes, pharmacological test shows that Rhizoma Curcumae processed with vinegar has the best effects.

Objective To explore the effect of self efficacy combined with mobile health information service applied in pulmonary rehabilitation in residence in elderly patients with chronic obstructive pulmonary disease. Methods Sixty-eight elderly patients in stable situation were divided into the control group and the intervention group with 34 cases in each group accoridng to the random digit table. In the control group, the nursing intervention included health education and telephone follow-up. The intervention group adopted self efficacy theory combined with mobile health information service. The items such as persistence in pulmonary rehabilitation, Exercise Self-Regulatory Efficacy Scale (Ex-SRES) and health condition were assessed. Results After intervention for 12 weeks, the scores of persistence in pulmonary rehabilitation in residence in the intervention group scored 5.35 ±1.42, which was higher than that in the control group (2.03±1.40), the difference was significant (t=160.43, P<0.01). Ex-SRES of the intervention group scored 62.06±13.10,91.21±11.12, which were higher than those of the control group, 50.38±18.03,42.56±18.23, the difference was significant (t=9.32,176.88, P<0.01) . The interaction between treatment effects and time effect was significant in COPD Assessment of Tool (CAT) and Ex-SRES respectively(F=489.95,P=0.00;F=134.80, P=0.00). Comparing value of CAT in baseline (24.97±4.74,24.62±5.39) and at the end of the twelfth week(24.94±4.74,24.65±5.35), the difference was not significant in two groups respectively(P>0.05). The improvement of CAT was significant at the end of the twenty-forth week (21.90±4.67) in the intervention group (t=-12.09, P<0.01). Conclusions Self efficacy theory and the application of mobile health information services can help patients persist in long-term rehabilitation exercise training.

To develop a high-performance liquid chromatographic method for the determination of isoguanosine in Semen Crotonis Tiglii.

Objective To apply short message service (SMS) for pulmonary rehabilitation in residence. Methods A total of 102 old pa-tients with chronic obstructive pulmonary disease (COPD) in stable situation were equally divided into three groups randomly. They all ac-cepted a two-week lesson of exercise project, and then took in the project for 22 weeks. Meanwhile, group A phoned to their experts once a week, group B was phoned by their experts once a week, and group C accepted SMS once a day and sent back to the experts. They were in-vestigated with Exercise Self Regulatory Efficacy Scale (Ex-SERS), modified British Medical Research Council Scale (mMRC) and COPD Assessment Test (CAT) before and after intervention. Results The score of Ex-SERS was the most in group C (F=179.53, P<0.001), with the interaction of time (F=387.09, P<0.001). While the scores of mMRC (F=8.754, P<0.001) and CAT (F=11.32, P<0.001) were the least in group C. Conclusion Application of SMS in the integrated management for pulmonary rehabilitation in residence may improve the self regu-latory efficacy of exercise, release the dyspnea and the influence on living in patients with COPD.