Objective: To evaluate the effects of a multidisciplinary weight management intervention, so as to provide a reference for the formulation of overweight and obesity intervention measures. Methods: From April to September 2025, overweight and obese residents aged 18-60 years who participated in a weight loss competition at the Health Management Center of Beilun People's Hospital in Ningbo City were selected as study subjects. They were divided into a control group and an intervention group. The control group received conventional weight management, while the intervention group received the multidisciplinary integrated weight management in addition to the conventional weight management, for a total intervention period of 8 weeks. Weight, body mass index (BMI), waist circumference, hip circumference, waist-to-hip ratio, fasting blood glucose (FBG), triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and blood pressure were collected before and after the intervention through physical examinations and laboratory tests. The generalized estimating equations (GEE) method was employed to analyze the differences in indicators between the two groups before and after the intervention. Results: The control group comprised 241 participants, including 161 females (66.80%), with a mean age of (35.66±7.80) years. The intervention group consisted of 127 participants, including 86 females (67.72%), with a mean age of (36.80±7.05) years. No statistically significant differences were observed between the two groups at baseline in terms of age, gender, weight, BMI, or waist-to-hip ratio (all P>0.05). Results from the GEE analysis indicated significant interactions between group and time for weight, BMI, waist circumference, and hip circumference (all P<0.05) with greater reductions in these parameters observed in the intervention group compared to the control group before and after the intervention. Similarly, significant interactions between group and time were observed for FBG, TG, TC, and LDL-C (all P<0.05), with the intervention group demonstrating larger decreases in these markers compared to the control group. However, no statistically significant interactions between group and time were observed for waist-to-hip ratio, HDL-C, systolic blood pressure, and diastolic blood pressure (all P>0.05). Following the intervention, a weight loss exceeding 10% was achieved by 13 participants (5.39%) in the control group and 62 participants (48.82%) in the intervention group. The proportion of individuals with a weight loss exceeding 10% was significantly higher in the intervention group compared to the control group (P<0.05). Conclusion Compared to conventional weight management, multidisciplinary integrated weight management demonstrated greater efficacy in improving weight-related indicators and blood glucose, blood lipids, and enhancing weight loss outcomes among overweight and obese residents.

Objective:To explore the application effect of pelvic floor outpatient intervention during pregnancy on vaginal delivery of full-term primiparous women.Methods:Single birth primipara who were willing to establish a card and have a desire to give birth naturally in the First People's Hospital of Longquanyi District from January 2021 to December 2021 were divided into odd and even number groups according to the order of filing:the odd group received routine obstetric outpatient management and pelvic floor outpatient intervention(Kegel exercise joint perineum massage)in 200 cases(research group),and even number group received routine obstetric outpatient management in 200 cases(control group).The incidence of vaginitis,cesarean section rate,vaginal delivery rate,obstetric laceration,vaginal midwifery rate,perineal incision,delivery outcome and the length of perineal body and reproductive hiatus before and 42 days after delivery,vaginal width andother vaginal delivery complications(urina-ry retention and puerperal hemorrhoids)were compared between the two groups.Results:87 cases were includ-ed in the final study group,while 104 cases were included in the control group.The perineal incision rate,perineal integrity rate,vaginal midwifery rate,l degree and Ⅱ degree perineal laceration rate,postpartum hemorrhage in the study group were better than those in the control group(P＜0.05).The length of reproductive hiatus 42 days after delivery in the study group was shorter compared with that in the control group(P＜0.05).There were no signifi-cant differences in the incidence of vaginitis,cesarean section rate,time of the second stage of labor,vaginal wall laceration rate,Apgar score of newborns neonatal birth trauma rate,urinary retention,puerperal hemorrhoids,post-partum vaginal width and perineal body length between the two groups(P＞0.05).Conclusions:Pelvic floor outpa-tient intervention during pregnancy can reduce the harm caused by vaginal delivery in full-term primiparas to a cer-tain extent,and does not increase the incidence of neonatal delivery complications,it is worthy of clinical promotion.

Objective:To explore the application effect of pelvic floor outpatient intervention during pregnancy on vaginal delivery of full-term primiparous women.Methods:Single birth primipara who were willing to establish a card and have a desire to give birth naturally in the First People's Hospital of Longquanyi District from January 2021 to December 2021 were divided into odd and even number groups according to the order of filing:the odd group received routine obstetric outpatient management and pelvic floor outpatient intervention(Kegel exercise joint perineum massage)in 200 cases(research group),and even number group received routine obstetric outpatient management in 200 cases(control group).The incidence of vaginitis,cesarean section rate,vaginal delivery rate,obstetric laceration,vaginal midwifery rate,perineal incision,delivery outcome and the length of perineal body and reproductive hiatus before and 42 days after delivery,vaginal width andother vaginal delivery complications(urina-ry retention and puerperal hemorrhoids)were compared between the two groups.Results:87 cases were includ-ed in the final study group,while 104 cases were included in the control group.The perineal incision rate,perineal integrity rate,vaginal midwifery rate,l degree and Ⅱ degree perineal laceration rate,postpartum hemorrhage in the study group were better than those in the control group(P＜0.05).The length of reproductive hiatus 42 days after delivery in the study group was shorter compared with that in the control group(P＜0.05).There were no signifi-cant differences in the incidence of vaginitis,cesarean section rate,time of the second stage of labor,vaginal wall laceration rate,Apgar score of newborns neonatal birth trauma rate,urinary retention,puerperal hemorrhoids,post-partum vaginal width and perineal body length between the two groups(P＞0.05).Conclusions:Pelvic floor outpa-tient intervention during pregnancy can reduce the harm caused by vaginal delivery in full-term primiparas to a cer-tain extent,and does not increase the incidence of neonatal delivery complications,it is worthy of clinical promotion.

Objective:To explore the application effect of pelvic floor outpatient intervention during pregnancy on vaginal delivery of full-term primiparous women.Methods:Single birth primipara who were willing to establish a card and have a desire to give birth naturally in the First People's Hospital of Longquanyi District from January 2021 to December 2021 were divided into odd and even number groups according to the order of filing:the odd group received routine obstetric outpatient management and pelvic floor outpatient intervention(Kegel exercise joint perineum massage)in 200 cases(research group),and even number group received routine obstetric outpatient management in 200 cases(control group).The incidence of vaginitis,cesarean section rate,vaginal delivery rate,obstetric laceration,vaginal midwifery rate,perineal incision,delivery outcome and the length of perineal body and reproductive hiatus before and 42 days after delivery,vaginal width andother vaginal delivery complications(urina-ry retention and puerperal hemorrhoids)were compared between the two groups.Results:87 cases were includ-ed in the final study group,while 104 cases were included in the control group.The perineal incision rate,perineal integrity rate,vaginal midwifery rate,l degree and Ⅱ degree perineal laceration rate,postpartum hemorrhage in the study group were better than those in the control group(P＜0.05).The length of reproductive hiatus 42 days after delivery in the study group was shorter compared with that in the control group(P＜0.05).There were no signifi-cant differences in the incidence of vaginitis,cesarean section rate,time of the second stage of labor,vaginal wall laceration rate,Apgar score of newborns neonatal birth trauma rate,urinary retention,puerperal hemorrhoids,post-partum vaginal width and perineal body length between the two groups(P＞0.05).Conclusions:Pelvic floor outpa-tient intervention during pregnancy can reduce the harm caused by vaginal delivery in full-term primiparas to a cer-tain extent,and does not increase the incidence of neonatal delivery complications,it is worthy of clinical promotion.

Objective:To explore the application effect of pelvic floor outpatient intervention during pregnancy on vaginal delivery of full-term primiparous women.Methods:Single birth primipara who were willing to establish a card and have a desire to give birth naturally in the First People's Hospital of Longquanyi District from January 2021 to December 2021 were divided into odd and even number groups according to the order of filing:the odd group received routine obstetric outpatient management and pelvic floor outpatient intervention(Kegel exercise joint perineum massage)in 200 cases(research group),and even number group received routine obstetric outpatient management in 200 cases(control group).The incidence of vaginitis,cesarean section rate,vaginal delivery rate,obstetric laceration,vaginal midwifery rate,perineal incision,delivery outcome and the length of perineal body and reproductive hiatus before and 42 days after delivery,vaginal width andother vaginal delivery complications(urina-ry retention and puerperal hemorrhoids)were compared between the two groups.Results:87 cases were includ-ed in the final study group,while 104 cases were included in the control group.The perineal incision rate,perineal integrity rate,vaginal midwifery rate,l degree and Ⅱ degree perineal laceration rate,postpartum hemorrhage in the study group were better than those in the control group(P＜0.05).The length of reproductive hiatus 42 days after delivery in the study group was shorter compared with that in the control group(P＜0.05).There were no signifi-cant differences in the incidence of vaginitis,cesarean section rate,time of the second stage of labor,vaginal wall laceration rate,Apgar score of newborns neonatal birth trauma rate,urinary retention,puerperal hemorrhoids,post-partum vaginal width and perineal body length between the two groups(P＞0.05).Conclusions:Pelvic floor outpa-tient intervention during pregnancy can reduce the harm caused by vaginal delivery in full-term primiparas to a cer-tain extent,and does not increase the incidence of neonatal delivery complications,it is worthy of clinical promotion.

Objective:To explore the application effect of pelvic floor outpatient intervention during pregnancy on vaginal delivery of full-term primiparous women.Methods:Single birth primipara who were willing to establish a card and have a desire to give birth naturally in the First People's Hospital of Longquanyi District from January 2021 to December 2021 were divided into odd and even number groups according to the order of filing:the odd group received routine obstetric outpatient management and pelvic floor outpatient intervention(Kegel exercise joint perineum massage)in 200 cases(research group),and even number group received routine obstetric outpatient management in 200 cases(control group).The incidence of vaginitis,cesarean section rate,vaginal delivery rate,obstetric laceration,vaginal midwifery rate,perineal incision,delivery outcome and the length of perineal body and reproductive hiatus before and 42 days after delivery,vaginal width andother vaginal delivery complications(urina-ry retention and puerperal hemorrhoids)were compared between the two groups.Results:87 cases were includ-ed in the final study group,while 104 cases were included in the control group.The perineal incision rate,perineal integrity rate,vaginal midwifery rate,l degree and Ⅱ degree perineal laceration rate,postpartum hemorrhage in the study group were better than those in the control group(P＜0.05).The length of reproductive hiatus 42 days after delivery in the study group was shorter compared with that in the control group(P＜0.05).There were no signifi-cant differences in the incidence of vaginitis,cesarean section rate,time of the second stage of labor,vaginal wall laceration rate,Apgar score of newborns neonatal birth trauma rate,urinary retention,puerperal hemorrhoids,post-partum vaginal width and perineal body length between the two groups(P＞0.05).Conclusions:Pelvic floor outpa-tient intervention during pregnancy can reduce the harm caused by vaginal delivery in full-term primiparas to a cer-tain extent,and does not increase the incidence of neonatal delivery complications,it is worthy of clinical promotion.

Objective:To explore the application effect of pelvic floor outpatient intervention during pregnancy on vaginal delivery of full-term primiparous women.Methods:Single birth primipara who were willing to establish a card and have a desire to give birth naturally in the First People's Hospital of Longquanyi District from January 2021 to December 2021 were divided into odd and even number groups according to the order of filing:the odd group received routine obstetric outpatient management and pelvic floor outpatient intervention(Kegel exercise joint perineum massage)in 200 cases(research group),and even number group received routine obstetric outpatient management in 200 cases(control group).The incidence of vaginitis,cesarean section rate,vaginal delivery rate,obstetric laceration,vaginal midwifery rate,perineal incision,delivery outcome and the length of perineal body and reproductive hiatus before and 42 days after delivery,vaginal width andother vaginal delivery complications(urina-ry retention and puerperal hemorrhoids)were compared between the two groups.Results:87 cases were includ-ed in the final study group,while 104 cases were included in the control group.The perineal incision rate,perineal integrity rate,vaginal midwifery rate,l degree and Ⅱ degree perineal laceration rate,postpartum hemorrhage in the study group were better than those in the control group(P＜0.05).The length of reproductive hiatus 42 days after delivery in the study group was shorter compared with that in the control group(P＜0.05).There were no signifi-cant differences in the incidence of vaginitis,cesarean section rate,time of the second stage of labor,vaginal wall laceration rate,Apgar score of newborns neonatal birth trauma rate,urinary retention,puerperal hemorrhoids,post-partum vaginal width and perineal body length between the two groups(P＞0.05).Conclusions:Pelvic floor outpa-tient intervention during pregnancy can reduce the harm caused by vaginal delivery in full-term primiparas to a cer-tain extent,and does not increase the incidence of neonatal delivery complications,it is worthy of clinical promotion.

Objective:To explore the application effect of pelvic floor outpatient intervention during pregnancy on vaginal delivery of full-term primiparous women.Methods:Single birth primipara who were willing to establish a card and have a desire to give birth naturally in the First People's Hospital of Longquanyi District from January 2021 to December 2021 were divided into odd and even number groups according to the order of filing:the odd group received routine obstetric outpatient management and pelvic floor outpatient intervention(Kegel exercise joint perineum massage)in 200 cases(research group),and even number group received routine obstetric outpatient management in 200 cases(control group).The incidence of vaginitis,cesarean section rate,vaginal delivery rate,obstetric laceration,vaginal midwifery rate,perineal incision,delivery outcome and the length of perineal body and reproductive hiatus before and 42 days after delivery,vaginal width andother vaginal delivery complications(urina-ry retention and puerperal hemorrhoids)were compared between the two groups.Results:87 cases were includ-ed in the final study group,while 104 cases were included in the control group.The perineal incision rate,perineal integrity rate,vaginal midwifery rate,l degree and Ⅱ degree perineal laceration rate,postpartum hemorrhage in the study group were better than those in the control group(P＜0.05).The length of reproductive hiatus 42 days after delivery in the study group was shorter compared with that in the control group(P＜0.05).There were no signifi-cant differences in the incidence of vaginitis,cesarean section rate,time of the second stage of labor,vaginal wall laceration rate,Apgar score of newborns neonatal birth trauma rate,urinary retention,puerperal hemorrhoids,post-partum vaginal width and perineal body length between the two groups(P＞0.05).Conclusions:Pelvic floor outpa-tient intervention during pregnancy can reduce the harm caused by vaginal delivery in full-term primiparas to a cer-tain extent,and does not increase the incidence of neonatal delivery complications,it is worthy of clinical promotion.

Objective:To explore the application effect of pelvic floor outpatient intervention during pregnancy on vaginal delivery of full-term primiparous women.Methods:Single birth primipara who were willing to establish a card and have a desire to give birth naturally in the First People's Hospital of Longquanyi District from January 2021 to December 2021 were divided into odd and even number groups according to the order of filing:the odd group received routine obstetric outpatient management and pelvic floor outpatient intervention(Kegel exercise joint perineum massage)in 200 cases(research group),and even number group received routine obstetric outpatient management in 200 cases(control group).The incidence of vaginitis,cesarean section rate,vaginal delivery rate,obstetric laceration,vaginal midwifery rate,perineal incision,delivery outcome and the length of perineal body and reproductive hiatus before and 42 days after delivery,vaginal width andother vaginal delivery complications(urina-ry retention and puerperal hemorrhoids)were compared between the two groups.Results:87 cases were includ-ed in the final study group,while 104 cases were included in the control group.The perineal incision rate,perineal integrity rate,vaginal midwifery rate,l degree and Ⅱ degree perineal laceration rate,postpartum hemorrhage in the study group were better than those in the control group(P＜0.05).The length of reproductive hiatus 42 days after delivery in the study group was shorter compared with that in the control group(P＜0.05).There were no signifi-cant differences in the incidence of vaginitis,cesarean section rate,time of the second stage of labor,vaginal wall laceration rate,Apgar score of newborns neonatal birth trauma rate,urinary retention,puerperal hemorrhoids,post-partum vaginal width and perineal body length between the two groups(P＞0.05).Conclusions:Pelvic floor outpa-tient intervention during pregnancy can reduce the harm caused by vaginal delivery in full-term primiparas to a cer-tain extent,and does not increase the incidence of neonatal delivery complications,it is worthy of clinical promotion.

Objective To explore the relationship between geriatric nutritional risk index(GNRI)and adverse outcomes in elderly patients undergoing maintenance hemodialysis(MHD).Methods A prospective cohort trial was conducted on 337 MHD patients aged ≥60 years in hemodialysis centers of 11 hospitals in Beijing from April to June 2017.Their baseline data were collected,and they were divided into non-malnutrition(GNRI≥98,226 cases),mild malnutrition(92≤GNRI＜98,81 cases),and major malnutrition groups(GNRI＜92,30 cases).All of them were followed up until June 2018.The endpoint events were all-cause mortality and cardiovascular disease(CVD)mortality.Kaplan-Meier survival analysis was used to compare the cumulative survival rate among the 3 groups.Multivariate Cox regression model was employed to analyze the relationship of GNRI with all-cause and CVD mortality.Results The mild and major malnutrition groups had significantly lower BMI,serum albumin level and GNRI(P＜0.01).During the median follow-up of 52(4.4-52.0)weeks,56(16.6％)patients died of all-cause death and 25(44.6％)of CVD death.Kaplan-Meier survival curve showed significant differences in all-cause mortality(x2=30.484,P＜0.01)and CVD mortality(x2=22.398,P＜0.01)in the 3 groups.Multivariate Cox regression analysis indicated that,as a continuous variable,elevated GNRI was a protective factor for all-cause mortality(HR=0.910,95％CI:0.870-0.952,P=0.000)and CVD mortality(HR=0.895,95％CI:0.852-0.940,P=0.000),and as a categorical variable,mild and major malnutri-tion were independently correlated with all-cause and CVD mortality(P＜0.05).Conclusion GNRI is an independent risk factor for all-cause and CVD mortality in elderly MHD patients.Mo-nitoring the nutritional status using GNRI can predict the risk of adverse prognosis.