Objective To investigate the expression of HLA DR on the platelet membrane and the activation of CD4 +T lymphocyte with idiopathic thrombocytopenic purpura (ITP) Methods By flow cytometry, HLA DR expressed on platelet membrane and IL 2 level produced by activated CD4 +T lymphocyte in 60 patients with ITP and 60 normal volunteers were measured Results The percentage of platelet expressing HLA DR (0 808?0 218)% measured in 60 patients with ITP by flow cytometry analysis was markedly higher than that in control subjects (0 025?0 019)% ( P

Objective To observe the effect of Changtong Oral Liquid (CTOL) on serum TNF-? and IL-4 levels in rats with postoperative intestinal adhesion. Methods Sprague-Dawley (SD) male rats were randomly divided into six groups: normal control, no treatment control, Simo Oral Liquid (SOL) group, and CTOL group (minimal, medium and maximal dosages). Except for normal control group, intestinal adhesions were produced in all the other rats with the method of Ellis. The blood samples of rats with CTOL medium dosage and no treatment group were collected on the 1st, 3rd, 5th, 7th and 9th day, and that of the rest was drawn on day 7 after surgery for the determination of TNF-? and IL-4 levels. Results The serum TNF-? levels were higher in no treatment rats compared with the normal controls (P0.05). Conclusions TNF-? was closely related to adhesion formation, and it may be regarded as a marker of adhesion formation.

OBJECTIVE:To observe clinical efficacy and safety of pidotimod combined with montelukast sodium in the treat-ment of children with bronchial asthma. METHODS:120 children with bronchial asthma were randomly divided into control group and observation group,with 60 cases in each group. Both group were given routine treatment as aerosol inhalation of glucocorticoid and anti-infective treatment. Control group was additionally given Montelukast sodium chewable tablet 5 mg orally,qd,at bed-time;observation group was additionally given Pidotimod capsule 0.4 g,qd,on the basis of control group. Both group received treatment for consecutive 3 months. Clinical efficacies of 2 groups were observed as well as IL-4,IFN-γ,IgE,T lymphocyte sub-set and lung function indexes of 2 groups before and after treatment. The occurrence of ADR were compared between 2 groups. RE-SULTS:The effective rate of observation group was 88.3%,which was significantly higher than that of control group (61.7%). There was no statistical significance in IL-4,IFN-γ,IgE,T lymphocyte subset and lung function indexes between 2 groups before treatment(P>0.05). After treatment,IL-4,IFN-γ,IgE,CD4+,CD4+/CD8+ and lung function of 2 groups were improved signifi-cantly,and the observation group was significantly better than the control group,with statistical significance(P<0.05). There was no statistical significance in the incidence of ADR between 2 groups(P>0.05). CONCLUSIONS:Pidotimod combined with monte-lukast sodium is effective for children with bronchial asthma,and can significantly relieve airway inflammation,enhance immunity and improve lung function with good safety.

Objective To discuss the efficacy of neural endoscopic and surgical operation in patients with cerebral hemorrhage induced by hypertension.Methods Sixty cases with cerebral hemorrhage induced by hypertension admitted at the People′s Hospital of Bortala from January 2015 to June 2016 were divided into the control group(n=32) and research group(n=28) according to cerebral hemorrhage surgical method.The patients of the control group were given conventional surgical operation treatment while the observation group were given neural endoscopic treatment.The operative time and intraoperative blood loss,and situation of hematoma absorption before and after operation and prognosis between the two groups were compared.Results The operative time and intraoperative blood loss of the two groups were respectively (132.6±35.4) min,(49.8±12.3) ml and (236.5±46.2) min,(263.5±49.8) ml,the observation group were obviously lower than that of the control group,the differences were statistically significant(t=6.532,9.548,all P<0.05).The preoperative hematoma volume,postoperative hematoma volume and hematoma clearance of the two groups were respectively (6.8±1.5) ml,(82.7±6.3)% and (16.3±3.1) ml,(57.8±5.2)%,the postoperative hematoma volume of observation group were obviously lower than that of the control group while the hematoma clearance obviously increased,the differences were statistically significant(t=6.584,-5.263,all P<0.05).The ADL assessment in patients of observation group was better than the control group and the death rate was lower than that of control group,the differences were statistically significant(3.6%(1/28) vs.21.9%(7/32),χ2=10.580,4.329,all P<0.05).Conclusion The efficacy of neural endoscopic applied in patients with cerebral hemorrhage induced by hypertension is remarkable,it causes little damage to the body and can obviously improve the effect of prognosis,it is worth popularization and application.

Objective: To observe the Prevention Action of Changtong Oral Liquid (CTOL) on the postoperative intestinal adhesions in rabbits. Method: Thirty-six male New Zealand rabbits were randomly divided into six equal groups (n=6): Normal control (group 1); model control (group 2); Simo Decoction (group 3); and CTOL minimal, medium and maximal dosages (group 4,5,6). Except group 1, the other rabbits were created as intestinal adhesive models. Group 1 and group 2 were orally fed with distilled water (20ml/kg), and group 3 to 6 with Simo Decoction 10ml/kg and CTOL in doses of 2.15g/kg, 4.30g/kg and 8.60g/kg respectively. On day 3 after surgery, the blood samples were collected to determine the fibrinolytic activity, and on day 9 the adhesion was graded. Result: CTOL could evidently reduce the severity of postoperative adhesions and increase plasma tPA activity and inhibit plasma PAI-1 activity. Conclusion: CTOL could prevent postoperative intestinal adhesion formation.

Objective:To evaluate the clinical effect of the independent research and development of the soak paper device used for patients in bed.Methods: To add a soak sensitive receiver and a soak signal transmitter on the extension pager device in the ward and have them connected with the wire to form a new type of soak pager device.Results:Using a new type of wet pager device can transmit signal in time when one-time pad single was wet for the patients in bed and avoid skin wet of the patients for a long time. All the patient and their families were very satisfied.Conclusion: The self-made and a new type of wet pager device used for patients in bed can better protect the patient’s skin and save manpower. The device is convenient and simple, the application is safe and effective.

Objectives To investigate the effect of cerebrespinal fluid replacement using three- way pipe on subarachnoid hemorrhage and the nursing points were summarized. Methods 80 subarachnoid hemorrthage patients were divided into the treatment group and the control group with 40 patients in each group. The control group received traditional medical treatment and routine nursing. The treatment group received cerebrospinal fluid replacement.The incidence of complication,death and clinical effect were com-pared between the two groups and the data under χ2 test and t test. Results Each index in the treatment group was better than that of the control group. Conclusions Intensified nursing after cerebrospinal fluid replacement can improve treatment effect, alleviate prognosis and supply reference for future nursing work for this disease.

ObjectiveTo explore the blood glucose changes in diabetes mellitus (DM) patients with acute myocardial infarction(AMI) and its influence on heart function.MethodsSeventy-three patients with AMI were divided into DM group (35 cases) with DM and non-DM group (38 cases) without DM.The blood glucose changes and the relationships with heart functon were observed in two groups.ResultsIn DM group,33 cases(94.29％,33/35) had high fasting blood glucose,whereas in the non-DM group,14 cases(36.84％,14/38) had stress hyperglycemia.The levels of fasting blood glucose and glycosylated hemoglobin in the DM group were significantly higher than those in the non-DM group [(9.7 ± 2.4) mmol/L vs.(5.8 ± 2.3) mmol/L,(10.13 ±1.95 )％ vs.(7.22 ± 1.87)％,P ＜ 0.05 ].The levels of creatine kinase isozyme MB (CK-MB) and troponin T (TnT) in the DM group were significantly higher than those in the non-DM group [ ( 217 ± 53 ) U/L vs.( 119 ± 47 ) U/L,( 6.2 ± 3.7 ) mg/L vs.( 3.4 ± 2.9 ) mg/L,P ＜ 0.05 ].The detection of left ventricular function after 4 weeks of AMI showed that left ventricular end diastolic volume (EDV) and end systolic volume (ESV) of the DM group were significantly higher and LVEF was significantly lower than those of the non-DM group [ (81.7 ± 10.8 ) ml vs.(74.9 ± 10.2 ) ml,(47.6 ± 10.7 ) ml vs.(39.8 ±12.6) ml,(41.7 ± 4.8)％ vs.(48.9 ± 8.5)％,P＜ 0.05 ].ConclusionsPatients with AMI and DM have high hyperglycemia and worse heart function.Therefore,intervention measures should be performed for these patients.

Objective To evaluate the security of intravitreal injection with ciproflaxacin to retina. Methods Tweenty-four rabbits were randomly divided into 4 groups with 6 rabbits in each group. 0.1 ml ciproflaxacin in doses of 2 500, 5 000, and 10 000 ?g was intravitreally injected into the rabbits eyes, retrospectively. And 0.1 ml saline solution was injected into the vitreous body of the rats in the control group. Indirect microscope, light microscope and electroretinogram (ERG) were used to observe the changes of ocular fundus. Results Normal results of light microscopy and ultrastructure were found in 250 ?g and 500 ?g groups; irregularly arranged outer and inner nuclear layers, dropsical or even lost ganglion cells, and ultrastructural changes were in 1 000 ?g group. There was no apparent difference of ERG′s a and b amplitudes before and after intravitreal injection with ciproflaxacin in each group. Conclusion Intravitreal injection with ciproflaxacin is safe, and 500 ?g or less is the secure dosage in rabbits' eyes.

Objective To evaluate the relationship of fibrinolytic activity with hematoma enlargement in spontaneous intracerebral hemorrhage (ICH).Methods 107 patients with ICH were divided into two distinct groups according to the change of hematoma after admission: patients with hematoma enlargement and patients without hematoma enlargement. The activity of tissue-type plasminogen activator (tPA:A) and plasminogen activator inhibitor (PAI:A) in plasma were assayed by meaos of synthetic chromogenic substrate method, and the levels of plasminogen activator inhibitor-1 (PAI-1) antigen and D-dimer (D-D) were measured with an enzyme-linked immunosorbent assay (ELISA). The blood samples were obtained at 0～3 d, 4～9 d and 14～21 d after onset of the disease, respectively. All of the parameters were compared with healthy subjects. Results The tPA:A in ICH patient group at 0～3 d and 4～9 d after onset were significantly lower than those in control group (P