Objective:To explore the preventive effect of moxibustion on six acupoints around the knee on perioperative deep venous thrombosis (DVT) of the lower extremity in patients undergoing total knee arthroplasty.Methods:Using the convenient sampling method, a total of 80 patients who underwent single total knee arthroplasty in Foshan Hospital of Traditional Chinese Medicine in Guangdong Province from January 2018 to October 2019 were selected as the research objects. According to the random number table method, they were divided into the control group and the observation group with 40 cases in each group. The control group was given conventional treatments and nursing such as subcutaneous injection of low molecular weight heparin calcium and the observation group was given moxibustion on six acupoints around the knee on the basis of the control group. Patients in the two groups were observed for 14 days. Changes in circumference difference of calf (before operation, 1, 7, 14 days after operation) , plasma prothrombin time (PT) , activated partial thromboplastin time (APTT) and D-dimer were compared between two groups. DVT formation was compared between the two groups on the 14th day after surgery and satisfaction of patients was evaluated.Results:The differences in calf circumference of the operating limbs within each group were statistically significant on the first day after operation and before operation ( P<0.05) . There were statistically significant differences between the 7th and 14th day after operation and the first day after operation ( P<0.05) . There was no statistically significant difference in calf circumference difference between the two groups before and on the first day after the operation ( P>0.05) . The differences between the two groups on the 7th and 14th day after operation were statistically significant ( P<0.05) . There were statistically significant differences in PT, APTT and D-dimer on the first day after surgery and before surgery within each group ( P<0.05) , and there were statistically significant differences between the 7th and 14th day after surgery and the first day after surgery ( P<0.05) . There was no statistically significant difference in PT, APTT and D-dimer before operation and on the 1st and 7th day after operation between the two groups ( P>0.05) . On the 14th day after operation, the differences of PT, APTT, D-dimer between the two groups were statistically significant ( P<0.05) . A total of 6 patients (15.0%) in the control group had DVT, but no DVT occurred in the observation group, the total satisfaction rate of the observation group was higher than that of the control group, and the differences were statistically significant ( P<0.05) . Conclusions:Moxibustion on six acupoints around the knee can reduce the swelling of the lower limbs after operation, improve coagulation function and prevent the occurrence of DVT, which has higher satisfaction of patients.