Objective To investigate the influence and the efficacy for lipid level of rosuvastatin with atorv-astatin in the treatment of coronary heart disease.Methods 160 patients with coronary heart disease were randomly divided into the observation group and the control group,80 cases in each group.The patients of the observation group were given rosuvastatin 10mg every night,the control group were treated with the same dose of atorvastatin every night,the efficacy before and after treatment were compared after continuous 21d,and the lipid changed of the two groups were compared.Results There were statistically significant difference in the lipid level of the observation group before and after treatment(t =3.728,4.516,5.322,3.143,all P <0.05),and after treatment the TC,TG,LDL-C levels of the observation group were lower than those of the control group,the HDL -C level was higher than that of the control group,the difference was statistically significant(t =3.512,5.529,6.325,3.139,all P <0.05);There were statistically significant differences in hs -CRP,Hcy,IMT of the observation group before and after treatment [(14.35 ±1.56)μmol/L vs (22.45 ±1.82)μmol/L,(0.31 ±0.03)g/L vs (0.45 ±0.06)g/L,(1.64 ±0.11)mm vs (2.03 ±0.12)mm](t =3.728,3.231,3.452,all P <0.05),and the hs -CRP,Hcy,IMT of the observation group were lower than those of the control group[(14.35 ±1.56)μmol/L vs (16.56 ±1.26)μmol/L,(0.31 ±0.03)g/L vs (0.38 ±0.05)g/L,(1.64 ±0.11 )mm vs (1.81 ±0.12)mm](t =3.512,3.529,4.325,all P <0.05 ). Conclusion The treatment effect and lipid level of rosuvastatin was superior to atorvastatin.

BACKGROUND: Craniofacial hard tissue structures vary in age, gender, regional and racial differences. Some researchers have conducted X-ray cephalometric measures of malocclusion deformity in some domestic cities, and obtained normal cephalometric measures of craniofacial hard tissue structure. However, little data have been available concerning cephalometric measures of craniofacial hard tissue structure of Tibetan youth in Tibet region. OBJECTIVE: To observe structural features of craniofacial hard tissue of permanent tooth occlusal period in the adolescent of Lhasa. DESIGN, TIME AND SETTING: Stratified cluster sampling survey was performed at Naqu, Tibet from June to August 2008. PARTICIPANTS: A total of 200 adolescents at permanent tooth occlusal period, 100 males and 100 females aged 11-14 years were selected from middle and primary schools of Lhasa in 2003. The inclusion criteria included: teeth in order, neutral occlusal adjustment, normal maxilla and mandible appearance and relationship, normal teeth number and overbite and overjet, concordant face, and no history of orthodontic management. METHODS: According to the requirements and standards for the irradiation, 200 subjects underwent X-ray cephalometric measures, and the results were compared with normal values of the same age. MAIN OUTCOME MEASURES: SNA angle, SNB angle, ANB angle, 1-SA angle, 1-NA angle, 1-NA, T-MP angle, Y axial angle, NP-FH angle, NA-PA angle, 1-T angle, MP-SN angle, Po-NB, T-NB angle, T-NB, and MP-FH angle. RESULTS: No significant differences were found between Lhasa adolescents and normal values in terms of SNA angle, SNB angle, ANB angle, 1-SN angle, 1-NA angle, 1-NA, T-MP angle, Y axial angle, NP-FH, NA-PA, 1-T, and MP-SN. Po-NB was slightly greater than normal value and T-NB angle, T-NB and MP-FH were significantly less than normal values. CONCLUSION: Lhasa adolescents have significantly different craniofacial hard tissue structure from normal values: forward protrusion of mental region, flat mandible angle, straight mandible anterior teeth, upward and forward rotated mandible, and straight face type.

We have studied the inhibitory effect of polysaccharides mixture on Ehrlich Ascites Carcinoma (EAC), Sarcoma 180 (S180), reticulocytic leukemia (L615) in mice. It is found that polysaccharides mixture could obviously prolong the survival duration of mice suffering from tumour and inhibit neoplastic proliferation. Thymus and adrenal glands atrophy in mice caused by vaccination of cancer cells was also remarkably resisted.The results of our experiments show that polysaccharides mixture is a safe,effective and promising pharmaceutic preparation of traditional Chinese medicine. It deserves to be further studied and developed.

Objective To study the clinical value of peripheral venous blood circulating tumor cell count in patients with non -small -cell lung cancer (NSCLC).Methods 28 patients with NSCLC were chosen as observa-tion group,at the same time,16 patients with benign lung tumor and 16 healthy persons were chosen as the control group 1,2.Before and after treatment,the peripheral venous blood circulating tumor cell counts were studied to under-stand its value in clinical.Results CK -FITC expression rate of adenocarcinoma patients was 95.8%,CD326APC expression rate was 94.5%,CK -FITC and CD326APC expression rate was 94.6%.CK -FITC expression rate of squamous carcinoma was 93.7%,CD326APC expression rate was 93.9%,CK -FITC and CD326APC expression rate was 94.1%,the differences between the two groups were not significant (χ2 =2.89,1.36,2.14,all P >0.05).The positive rate of peripheral venous blood circulating tumor cells in the observation group was significantly higher than the two control groups,and before treatment,the positive rate of peripheral venous blood circulating tumor cell was higher than after treatment.Conclusion Peripheral venous blood circulating tumor cell count can determine the dis-ease development process.

Objective To study the effect and mechanism of polypeptide from Chlamys farreri(PCF) on the thymocytes damaged by 60Co γ-rays. Methods The ceils were randomly divided into six groups: control group, 60Co groups (2 Gy, model),60Co + 0.5% PCF, 60Co+ 0.25% PCF, 60Co + 0.125% PCF, 60Co +0.1% VitC. The concentration of GSH-Px, ROS, A-SAC, T-AOC and the cells' viability were determined. The mitochondria membrane potential were tested. The expressions of P53, Bax and Bel-2 proteins were examined.Results The activities f GSH-Px, A-SAC, T-AOC in cells were enhanced, and the amounts of ROS were decreased by PCF. The expression of Bcl-2 gene was up-regulated, and down-regulated for the expression of P53 and Bax. All observed indexes of the PCF groups were significantly different compared with model group (P <0.05). Conclusions PCF has the protective effects on damages of thymocytes caused by 60Co irradiation. The mechanisms might be related to inhibiting of lymphocyte apoptosis and enhancing the activities of lymphocytes.

BACKGROUND:Craniofacial hard tissue structures vary in age,gender,regional and racial differences.Some researchers have conducted X-ray cephalometric measures of malocclusion deformity in some domestic cities,and obtained normal cephalometric measures of craniofacial hard tissue structure.However,little data have been available concerning cephalometric measures of craniofacial hard tissue structure of Tibetan youth in Tibet region.OBJECTIVE:To observe structural features of craniofacial hard tissue of permanent tooth occlusal period in the adolescent of Lhasa.DESIGN,TIME AND SETTING:Stratified cluster sampling survey was performed at Naqu,Tibet from June to August 2008.PARTICIPANTS:A total of 200 adolescents at permanent tooth occlusal period,100 males and 100 females aged 11-14 years were selected from middle and primary schools of Lhasa in 2003.The inclusion criteria included:teeth in order,neutral occlusal adjustment,normal maxilla and mandible appearance and relationship,normal teeth number and overbite and overjet,concordant face,and no history of orthodontic management.METHODS:According to the requirements and standards for the irradiation,200 subjects underwent X-ray cephalometric measures,and the results were compared with normal values of the same age.MAIN OUTCOME MEASURES:SNA angle,SNB angle,ANB angle,1-SA angle,1-NA angle,1-NA,?-MP angle,Y axial angle,NP-FH angle,NA-PA angle,1-? angle,MP-SN angle,Po-NB,?-NB angle,?-NB,and MP-FH angle.RESULTS:No significant differences were found between Lhasa adolescents and normal values in terms of SNA angle,SNB angle,ANB angle,1-SN angle,1-NA angle,1-NA,?-MP angle,Y axial angle,NP-FH,NA-PA,1-?,and MP-SN.Po-NB was slightly greater than normal value and ?-NB angle,?-NB and MP-FH were significantly less than normal values.CONCLUSION:Lhasa adolescents have significantly different craniofacial hard tissue structure from normal values:forward protrusion of mental region,flat mandible angle,straight mandible anterior teeth,upward and forward rotated mandible,and straight face type.

BACKGROUND: Presently, it is a certain preventive effect of local emplacement of various isolated materials during operation and postoperatively drug-controlled inflammatory reaction on adhesion between epidural and nerve root after laminectomy.OBJECTIVE: To study the preventive effect of chitosan and titanium net on epidural cicatricle adhesion after laminectomy.DESIGN, TIME AND SETTING: Randomized controlled animal study, which was performed in Guiyang Medical College from June to December 2005.MATERIALS: Eighty adult rabbits, weighing (2.0±0.2) kg, were used to establish vertebral plate resection models. Chitosan was provided by Shanghai Qisheng Biological Agent Industry Company, and titanium net by Guizhou Kelun Pharmacology Company Limited.METHODS: Eighty adult rabbits were randomly divided into four groups, including control group (0.5 mL saline), titanium net group (titanium net in the size of 1.0 cm × 0.8 cm was covered on defect region of vertebral plate and fixed on processus spinosus of upper and lower cone, bilateral muscles and soft tissues), chitosan group (2 mL chitosan), and chitosan + titanium net group (combination of chitosan and titanium net). Six rabbits were sacrificed in the 2nd and 4th weeks postoperatively, and eight rabbits were chosen as the samples in the 8th week.MAIN OUTCOME MEASURES: Morphological changes of cicatricle.RESULTS: Cicatricle was clearer in the control group. Titanium net could relieve peripheral cicatricle of dura mater and effectively isolate peripheral cicatricial tissue and spinal dura meter. Chitosan could remarkably prevent from cicatricle adhesion and inhibit inflammatory reaction. The combination of chitosan and titanium net could effectively inhibit proliferation of cicatricle surrounding dura meter.CONCLUSION: Association of chitosan and titanium net can effectively inhibit cicatricle adhesion surrounding dura meter after laminectomy.

60 kg) was given to all the patients 1-3 days after their operation.The pacing threshold and the amplitude of P and R waves on cardiograph were measured before injection and at 10,30,90,180 minutes afterwards.Results No significant changes were oburved in pacing threshold and the amplitade of P and R waves before and after the injection of metoprolol in patients with either newly implanted or replacement of permanent pacemakers.Conclusion Metoprolol tartrate has no effect on atrial and ventricular pacing threshold and the amplitude of P and R waves in patients with permanent pacemakers implantation.

BACKGROUND:Studies have demonstrated that tetrandrine has protection on acute spinal cord injury,but the specific mechanism remains poorly understood.OBJECTIVE:To study the protection of tetrandrine on rat acute spinal cord injury and to study its mechanism from apoptosis pathway.METHODS:A total of 100 rats were randomly divided into 4 groups.All rats were prepared for spinal cord injury models using modified Allen method except that in the sham-surgery group.Methylprednisolone and tetrandrine was injected into rats in the methylprednisolone and tetrandrine groups by tail intravenous injection prior to and at 24,48 hours after model preparation.The same volume of physiological saline was injected in the sham-surgery and model groups.Basso-BeatUe-Bresnahan(BBB score)was recorded at 8 hours,1,3,7 and 14 days after model preparation.The morphological changes of spinal cord injury sites were observed by hematoxylin-eosin staining and the expressions of bcl-2 and bax were determined by immunohistochemistry.RESULTS AND CONCLUSION:The BBB score of methylpradnisolone and tetrandrine groups were significantly higher than that model group at 7 and 14 days(P<0.05),but there were no significant difference between the methylprednisolone group and tetrandrine group(P>0.05).Hematoxylin-eosin staining showed that the spinal cord injured severely at 3-7 days,the injury degree in the methylpradnisolone group and tetrandrine group was slighter than that of the model group,with smaller bax expression and greater bcl-2 expression(P<0.01).The findings demonstrated that,tetrandrine is able to protect neurons from apoptosis and promote the nerve function recovery by inhibiting the expression of Bax and promoting the expression of Bcl-2.Its effect is not inferior to methylprednisolone.

Background:Besides typical gastroesophageal reflux symptoms,some reflux esophagitis( RE)patients also complain“morning sour taste in mouth”,but related studies are rare. Aims:To study the pathophysiology of RE with sour taste in mouth. Methods:Fifty-two RE patients with typical regurgitation symptom and confirmed by endoscopy from Mar. 2013 to Oct. 2013 at Tianjin Medical University General Hospital were enrolled. Patients were divided into two groups according to whether there was an existence of morning sour taste in mouth. Results of esophageal manometry and 24-hour esophageal impedance-pH monitoring were analyzed. Nine healthy volunteers who had esophageal manometry performed were served as controls. Results:Length of lower esophageal sphincter( LESL)was shortened and LES pressure( LESP)and effective peristalsis of esophageal body were decreased in both RE groups when compared with controls( P ﹤ 0. 05 ). Upper esophageal sphincter pressure( UESP)was significantly lower and more nocturnal reflux episodes occurred in RE group with sour taste than those without( P ﹤ 0. 05 );however,no significant differences in other manometric and reflux parameters were found between RE groups with and without sour taste(P﹥0. 05). Conclusions:Esophageal motility and reflux events in RE patients with morning sour taste in mouth are somewhat different from those without sour taste. Decrease in UESP might be an important pathophysiological mechanism of sour taste in mouth in RE patients.