Objective To evaluate the efficacy and safety of carotid endarterectomy (CEA) in restenosis after carotid stenosis stenting.MethodsIn a prospective study, 29 patients with restenosis after carotid artery stenosis stenting, admitted to our hospital from January 2017 to December 2017, were selected as study group; and 29 patients with moderate or severe carotid artery stenosis matched with age, gender and course of disease and admitted to our hospital at the same period were selected as control group. All of them were treated with CEA, and patients in the study group also had their stents removed. The patients in the two groups were compared in terms of surgical indicators, efficacy, perioperative complications and incidence of adverse events during follow-up.ResultsThe success rate of surgery was 100％ in both groups; the intraoperative flow rate was 10.34％ in the control group and 17.24％ in the study group without statistically significant difference (P>0.05). There were no significant differences in carotid artery occlusion times and operation times between the two groups (P>0.05). The lengths of skin incision and carotid artery incision in the study group were significantly longer than those in the control group (P<0.05). The symptom improvement rates were 93.1％ and 89.66％, respectively, in the study group and 96.55％ and 93.1％ in the control group three and 12 months after surgery. There was no significant difference in symptom improvement degree and maximum carotid systolic velocity (PSV) between the two groups (P>0.05). The incidence of perioperative complications was 10.34％ in the study group, and the incidence of adverse events was 10.34％ in the follow-up period, and 3.45％ and 6.90％ in the control group, respectively, without statistically significant differences (P>0.05).Conclusions CEA is effective in the treatment of restenosis after carotid stenosis stenting. Because of stent dissection,中华神经医学杂志2019年11月第18卷第11期Chin J Neuromed, November 2019, Vol.18, No.11 the skin and carotid artery incision lengths are relatively long, but it does not increase the surgery risks and complications.