Objective:To explore the application effect of WeChat-based IIFAR combined with progressive exercise prescription in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI) .Methods:Using the convenient sampling method, a total of 90 ACS patients from the First Affiliated Hospital of Air Force Military Medical University were selected as the research objects from June 2017 to June 2019. The patients were divided into the observation group and the control group, with 45 cases in each group by random number method. Patients in the control group adopted conventional nursing methods, while patients in the intervention group used WeChat-based IIFAR combined with progressive exercise prescription intervention. Coronary Self-Management Behavior Scale (CSMS) , 6 min walking test and exercise load test were used to compare the effects of the intervention.Results:A total of 3 cases in the control group and 1 case in the observation group dropped out. None of the patients had any adverse cardiac events during the study period. The scores of daily life management, social emotional management and medical disease management behaviors of the observation group were higher than those of the control group at 3 months after operation, and the differences were statistically significant ( P<0.05) . Three months after the operation, the 6-min walking distance and maximum exercise load of the observation group were higher than those of the control group, and the differences were statistically significant ( P<0.05) . Conclusions:WeChat-based IIFAR combined with progressive exercise prescription can improve the exercise load and self-management behavior of ACS patients after PCI.

【Objective】 To investigate the effect of ethanol extracts of Siwei Dihuang on the apoptosis of cardiomyocytes and its mechanism. 【Methods】 The experiment set the control group， model group， model group + ethanol extracts of Siwei Dihuang-L group， model group + ethanol extracts of Siwei Dihuang-M group， model group + ethanol extracts of Siwei Dihuang-H group， model group + miR-NC group， model group + miR-26b group model group + ethanol extracts of Siwei Dihuang-M + anti-miR-NC group， and model group + ethanol extracts of Siwei Dihuang-M + anti-miR-26b group. Flow cytometry was used to detect apoptosis； lactate dehydrogenase （LDH） kit， superoxide dismutase （SOD） kit， and malondialdehyde （MDA） kit were used to detect LDH， SOD activity and MDA content， respectively. Real-time quantitative PCR （RT-qPCR） was used to detect miR-26b and MAPK mRNA levels； luciferase report experiment was conducted to detect the targeting relationship between miR-26b and MAPK. 【Results】 Compared with those in control group， the apoptosis rate of the cardiomyocytes of the model group was significantly increased， MDA content and LDH activity were significantly increased， the activity of SOD was significantly decreased， miR-26b expression was significantly decreased， but MAPK mRNA expression was significantly increased （P<0.05）. Treatment with low， medium and high concentrations of ethanol extracts of Siwei Dihuang could reduce apoptosis rate， MDA content and LDH activity， increase SOD activity and increase miR-26b expression， and decrease MAPK mRNA expression （P<0.05）. Overexpression of miR-26b inhibited high glucose-induced cardiomyocyte apoptosis and oxidative stress. Inhibition of miR-26b reversed the inhibitory effect of ethanol extracts of Siwei Dihuang on H9C2 apoptosis and oxidative stress in high glucose-induced cells. miR-26b targeted and regulated MAPK. 【Conclusion】 Ethanol extracts of Siwei Dihuang can inhibit the apoptosis and oxidative stress of H9C2 cells in high glucose， and its mechanism may be related to the upregulation of miR-26b and MAPK expressions.