1.The effects of COE on the expression of VEGF and CECs of Hepal-6 tumor bearing mice
Ying HOU ; Chunlan NIE ; Yanqing LIU
International Journal of Traditional Chinese Medicine 2012;34(4):324-326
Objective To study the effects of Celastrus orbiculatus extracts (COE) on the expression of VEGF and CECs of Hepal-6 tumor bearing mice.Methods Animal Models of Hepal-6 portability liver tumor bearing mice were established and randomly assigned to six groups (eight mice per group) as follows:untreated control group,solvent vehicle control (DMSO) group,physiological saline control group,cisplatin-treated group,and different dosages COE-treated groups (40 mg/kg,20 mg/kg,10 mg/kg).To approach the effects of COE on the expression of VEGF and CECs in Hepal-6 toumor bearing mice.Results The ELISA and flow cytometer showed that COE could significantly inhibit the expression of VEGF(45.24±21.36) pg/ml and CECs (0.83 ± 0.10) % compared with the physiological saline control group (P< 0.01 ) with the dose of 20mg/kg.Conclusion COE could significantly down-regulate the expression of VEGF and CECs.It may be related with the effect of COE in inhibiting angiogenesis of tumor.
2.Combined chemotherapy of weekly paclitaxel and ifosfamide in the treatment of 23 patients with advanced non-small cell lung cancer.
Hongxia XU ; Chunlan NIE ; Zhuan HONG
Chinese Journal of Lung Cancer 2004;7(2):165-167
BACKGROUNDTo evaluate the efficacy and safety of weekly paclitaxel and ifosfamide in the treatment of advanced non-small cell lung cancer.
METHODSTwenty-three patients with advanced non-small cell lung cancer received paclitaxel 50-65 mg/m² IV weekly on days 1, 8, 15, and IFO 1.3 g/m² IV on days 2-4. The schedule was repeated every 28 days for two or three cycles as a course.
RESULTSOne patient had complete response and eight had partial response. Eleven patients had stable disease and three had progressive disease. The overall response rate was 39.1%. Twenty patients were followed-up. The 1-year survival was 40%(8/20) and the median survival duration was 8.9 months. The main toxicities were hematological toxicity (leukopenia, 69.6%, 16/23) and nausea/vomiting (47.8%, 11/23).
CONCLUSIONSCombined chemotherapy of weekly paclitaxel and ifosfamide is a good regimen for advanced non-small cell lung cancer with good efficacy and well-tolerated side effects.
3. Thoughts and principles of diagnosis and treatment of chronic refractory wounds in China
Wei DONG ; Yurui XIAO ; Minjie WU ; Duyin JIANG ; Lanjun NIE ; Yingkai LIU ; Jiajun TANG ; Ming TIAN ; Chunlan WANG ; Lifang HUANG ; Jiaoyun DONG ; Xiaozan CAO ; Fei SONG ; Xiaoyun JI ; Xian MA ; Yutian KANG ; Shuwen JIN ; Chun QING ; Shuliang LU
Chinese Journal of Burns 2018;34(12):868-873
The correct thoughts and principles of diagnosis and treatment of chronic refractory wounds need to be formulated. Through the relevant domestic and international consensus and based on clinical experience, the