Objective To explore the application of micro-lecture in the health education of patients with osteoporosis combined with spinal tuberculosis.Methods By convenient sampling method, 102 patients with spinal tuberculosis and osteoporosis of a tertiary hospital of Beijing were selected from January 2014 to January 2016. They were divided into the control group (n=52) and the observation group (n=50). Patients in the control group received routine health education, while patients in the observation group were given micro-lecture. Health education knowledge and satisfaction to health education of patients in two groups were compared.Results Before discharge, the score of health education questionnaire in the observation group was higher than that of the control group, in which cognition was (3.97±0.82), operation (4.03±0.78), emotion (4.04±0.79); there were statistically significant differences between two groups (t=4.295,4.996,4.732;P<0.01). The score of satisfaction to health education in the observation group was (96.88±2.14), and in the control group was (90.96±5.79) (t'=6.899,P<0.01).Conclusions Micro-lecture in health education for patients with spinal tuberculosis combined with osteoporosis get good effect, and it plays a positive role in the treatment and extended care of hospitalized patients.