Objective To investigate the effect of comfort care on patients ’ anxiety after video-assisted thoracoscope surgery ( VATS) .Methods 148 patients were randomly divided into the control group ( n=75 ) and the observation group ( n=73 ) .The control group performed routine nursing care , while the observation group performed special comfort care .Patients ’ anxiety on 1 day before operation and 7 days after operation were compared between groups .Results Patients’ mean score of anxiety on 1 day before operation was (55.58 ± 12.33).There was no significant difference between groups (χ2 =0.7, P>0.05).For the patients in the observation group, 16.44%had no anxiety, 61.64%had a mild anxiety, 17.81%had a moderate anxiety, and 4.11%had a severe anxiety 7 days after operation.For the patients in the control group , 13.33% had no anxiety, 13.33%had a mild anxiety, 70.67%had a moderate anxiety, and 2.67%had a severe anxiety 7 days after operation.The difference was significant (χ2 =46.88, P <0.05).Conclusions The comfort care intervention can improve the nurse-patient communication and can reduce the degree of anxiety . It also contributes to promoting the postoperative rehabilitation of patients and improving the quality of nursing care .