Objective To investigate the application of white light emitting diode (LED) in magnetic resonance room, in order to resolve the damageable problem of incandescent lights under the high magnetic field. Methods The white LEDs and the incandescent lights were installed in MR room, the number of damaged lights was compared after 300 hours. Chi-square test was used for the statistical analysis. And the illuminance and 50 000 hours electricity consumption between LED and incandescent lights were calculated. Results The number of damaged LED and incandescent lights was 2 and 32, respectively and there was a significant difference (χ~2 =48.813 ,P =0.000). The illuminance of the LED and incandescent lights was 155 lx and 100 lX at the 0.75 m horizontal level and the 50 000 hours electricity consumption was 200 kW and 5000 kW, respectively. Conclusion It is feasible and a great advantage to use the white LEDs in MR room lighting.

Object To study the effects of SINI TANG (SNT) on the rat aortic rings pre-contracted by high K + and phenylephrine (Phe). Methods The effects of SNT on the aortic rings in the presence of 60 mmol/L KCl and Phe (1?10 -9 -1?10 -4 mmol/L) were observed and t heir me chanisms were studied after treatment with Propranolol (Pro, 3?10 -6 mmol/ L) and Bay K8644 (BK, 1?10 -5 mmol/L) as tool drugs. Results SNT inhibited the contraction induced by cumulative Phe and decreased the maximum tension (T max ); Pro couldn't influe nce the effects of SNT. SNT attenuated the amplitude of contractile effect of hi gh K +; BK couldn't reverse the effects of SNT. Conclusion SNT can shift the dose-response curve to the right and decrease the T max . It shows that SNT is a kind of noncompe titive antagonism. SNT decreases the effect of high K + against contraction of the artery. BK, a L-type Ca 2+ channels activator, couldn't recover the inhibition induced by SNT. The results suggest that SNT inhibit ? 1 recep tor, while calcium channel may not be involved in attenuating the effect of SNT on high K +-induced contraction.

Pesticides plays an important role in the history of agricultural development,but the health hazards and environmental pollution problems are attracting increasing attention. Methyl parathion is one of the most widely used pesticides,its threat to human health caused increased emphasis. This paper introduced the chronic toxicity of methyl parathion to various systems such as the nervous system,endocrine system,immune system and reproductive system.

This study was aimed to discuss the distribution and protein expression level ofμ-opioid receptor (MOR) in hippocampus of premenstrual syndrome (PMS) liver-qi stagnation rat model, in order to initially reveal the action mechanism of PMS liver-qi stagnation and intervention effect ofShu-Yu (SY) capsule. Chronic restraint stress method was used to copy PMS liver-qi stagnation rat model.SY capsule ofTiao-Gan prescription was given as intervention. Immunofluorescence (IF) and western blot (WB) technique were used to detect MOR in hippocampal CA1 and CA3 brain area of rats from each group. The results showed that compared with the normal group, the hippocampus MOR distribution arrangement was messy with increased protein concentration in the model group (P< 0.01). After drug intervention, the MOR protein level returned to normal level. It was concluded that the pathogenesis of PMS liver-qi stagnation may be associated with high expression of MOR in hippocampus CA1 and CA3 region of rats. SY capsule can effectively correct and restore it to nearly normal level. It may be one of the central mechanisms in SY capsule treatment of PMS liver-qi stagnation.

Through the questionnaire on bilingual teaching in medical students,some problems were presented. This paper is intended to discuss the necessity and the present condition of bilingual teaching and find out some measures to improve bilingual teaching quality.

Objective:Based on Co-occurrence Matrix and Run-length Matrix,we studied cerebral infarction patients' MR image texture characters.The aim is to investigate the differences of lesion textures characters between patients' groups and normal control groups,so that we can use this tiny change to realize early diagnosis of cerebral infarction.Methods:Texture features were extracted from MR images of patients and normal control groups respectively.Fisher test was applied to choose valid textures characters and made features classifier.Results:Linear discriminant analysis can achieve 88.31% classification accuracy.This demonstrated that cerebral infarction patients and normal control groups have the differences of textures Characters in MR image.Conclusion:We can discover cerebral infarction patients' MR image texture characters change by texture analysis,so that early diagnosis of cerebral infarction would be realized.

BACKGROUND:The polymorphisms of dopamine receptor in promoter region wil affect the expression of the receptor, thereby affecting the dopaminergic neurotransmitter, final y lead to related diseases.
OBJECTIVE:To construct the dual luciferase reporter vector containing human DRD1 promoter region and determine its activity, which could provide the basic tool for studying the transcriptional regulation of DRD1 gene.
METHODS:DRD1 promoter sequence was amplified by PCR using the human blood genomic DNA and cloned into pGM-T vector. After sequencing, the correctly constructed vectors were ligated to the firefly luciferase reporter plasmid pGL3-Basic. The cloned pGL3-Basic vectors were transfected into HEK293 using cationic liposome method. In the meanwhile, PGL3-Basic vector with no promoter was co-transfected with pGL3-TK plasmid as negative control group. The relative fluorescence intensity was measured by chemiluminescence.
RESULTS AND CONCLUSION:(1) Recombinant luciferase reporter gene vectors were confirmed by restriction analysis and sequencing. (2) Compared with the negative control group, the HEK293 cel s transfected by recombinant vectors presented transcriptional activity. (3) In conclusion, luciferase reporter gene vectors containing DRD1 promoter region are successful y constructed and can provide the basic tool for further study on the transcriptional regulation of DRD1.

OBJECTIVE:To study the preparation of famotidine dispersible tablets and to observe the dissolution characteristics in vitro METHODS:To optimize the conditions for preparation by orthogonal design RESULTS:The tablets could completely disintegrate within 1 min;In vitro dissolution test showed T50=0 56min CONCLUSION:In comparison with commercial famotidine tablets,the dispersible tablets prepared in optimum condition were rapid in disintegration and homogenous in dispersal

Objective To explore the value of DWI combined with dynamic contrast-enhanced MR imaging (DCE MRI) in differential diagnosis of benign and malignant parotid gland tumors.Methods DWI and DCE-MRI was performed in 90 patients with parotid gland tumors (94 lesions),included 75 benign tumors and 19 malignant tumors.The ADCs were measured,and the type of time-intensity curve (TIC) was assessed.ROC curve was used to analyze the diagnostic efficacy of ADC values,TIC types and combination of the two methods in diagnosing benign and malignant tumors.Results The ADC values of malignant tumors ([1.02 ± 0.25] × 10a mm2/s) were significantly smaller than that of benign tumors ([1.38±0.44] × 10-3 mm2/s;t=5.170,P＜0.001).The sensitivity was 0.62 and specificity was 0.92,when type A (persistent),B (washout),and D (flat) tumors regarded as benign and type C (plateau) tumors regarded as malignant.Sensitivity and specificity were significantly improved in diagnosis of malignant tumors when combined type C and ADC＜1.36× 10-3mm2/s,which were 0.92 and 0.95,respectively.Conclusion Due to an overlap within benign and malignant parotid tumors,the diagnosis should not be addressed on the basis of ADC values alone.The TIC manifestations type A,B or D on DCE-MRI indicates benign parotid tumors,and type C indicates malignant diseases.When the TIC shows type C,combining ADC value can elevate the differential diagnostic efficacy of benign and malignant parotid tumors.

Objective To analyze the form and classification of adult knit supercilium,at the same time,to explore the principle and clinical effects of botulinum toxin type A injections in knit supercilium treatment.Methods Retrospective analysis of morphology and treatment was carried out in 104 Chinese adults knit supercilium.The patients were randomly enrolled in study group that were subjected to botulinum toxin type A injection for the first time in treatment of glabella wrinkles.Forms of wrinkle supercilium were classified;Targeted point injection of botulinum toxin type A was adapted,with the minimum dose to achieve satisfied effect.The treatment interval was over 4-6 months.treatment methods and effects were explored.Results Chinese knit supercilium according to the form was divided into 6 different types:U-shaped (19 cases),Ⅲ shaped (30 cases),V-shaped (20 cases),hanging needle shaped (19 cases),Ω shaped (10 cases),and reverse Ω shaped (6 cases).During observation period,there was no serious adverse reactions after treatment.Conclusions Stand ardization of personalized botulinum toxin type A injections for patients with knit supercilium plays a positive role.