Objective To investigate the effect of early bedside neuromuscular electrical stimulation combined with routine rehabilitation training on the prognosis of patients with acute cerebral infarction. Methods A total of 200 patients with acute cerebral infarction admitted in our hospital from January 2016 to January 2018 were randomly selected. According to the random number table method, these patients were divided into early bedside neuromuscular electrical stimulation therapy combined with routine rehabilitation training group (combined group, n=100) and the separate conventional rehabilitation training group (routine group, n=100). The NDF score, FMA score, MBI score, and clinical efficacy were compared between the two groups. Results The NDF scores after treatment were significantly lower than before treatment (P<0.05), and the FMA score and MBI score of the two groups after treatment were significantly higher than those before treatment (P<0.05). The NDF score in combined group was significantly lower than that in the routine group (P<0.05), and the FMA score and MBI score of the patients in combined group were significantly higher than that in the routine group after treatment (P<0.05). But the difference in the NDF score, FMA score and MBI score between the two groups before treatment was not significant (P>0.05). The total effective rate of treatment in the combined group was95.0％ (95/100), which was significantly higher than 81.0％ (81/100) in the routine group (P<0.05). Conclusion Early bedside neuromuscular electrical stimulation combined with conventional rehabilitation training can improve the prognosis of patients with acute cerebral infarction more effectively than conventional rehabilitation training.