Topical fluorouracil therapy is an advanced treatment for actinic keratoses, Bowen's disease, multiple basal cell epithelioma and other precancerous skin lesions. Because of extensive and frequent use of 5-fluorouracil(5 F-U) cream, some untoward effects, mostly allergic contact dermatitis and irritation dermatitis, can be anticipated. We have experienced a case of crural ulcer after accidental application of 5 F-U cream for treating the tinea cruris at drug store. The patient was 21 year oid man who had suffered from erythema, erosion and shallow ulceration with oozing, serosanguinous discharge, buming and stinging sensation on the both groins and its adjacent area of the scrotum. The skin lesion was not well responded to topical corticosteroid but controlled by wet dressing and zinc oxide lotion within 10 days of hospitalization. At the 20th hospital day, the skin was healed with remained follicular hyperpigmentation. A few days later, the tinea cruris was confirmed by direct microsopic examination and culture. Generally, topical 5 F-U spares normal cell, while selectively destroying the more rapidly proliferating celI, but there are some possible factors to induce destruction of non-proliferating cell in the highly penetrating area The skin penetration can be different depending upon the anatomical location.
Bandages ; Bites and Stings ; Bowen's Disease ; Carcinoma, Basal Cell ; Dermatitis ; Dermatitis, Allergic Contact ; Erythema ; Fluorouracil ; Groin ; Hospitalization ; Humans ; Hyperpigmentation ; Keratosis, Actinic ; Scrotum ; Sensation ; Skin ; Tinea ; Ulcer* ; Zinc Oxide

Frason' a new topical steroid ointment containing 0.05% 17-desoxymethason and 0.5 % framycetin, was in trial for several kinds of dermatoses. Total 40 patients including 8 cases of contact dermatitis, 6 seborrheic dermatitis, 4 atopic dermatitis, 4 pityriasis rosea, 4 acne vulgaris, 3 nummular eczema, 3 psoriasis vulgaris, 3 pustulosis palmaris et plantaris and 1 folliculitis were treated with Frason', and the results were as follows. 1) 29 patients revealed excellent or good therapeutic effects (72.5%) with unoccluded application of Frason ointment, 2 or 3 times daily, among the 40 patients. 2) In comparison with the 0.05% Frason' ointment and the 0.05% betamethasone- gentamycin cream, the 0.05% Frason' ointment was found to be slightly more effeetive in the aspect of anti-inflammatory and anti-bacterial action. 3) W/0 base of Frason' ointment had slightly irritating reaction compare to O/W base of betamethasone cream, There was no side effect except 1 patient who complained of buming sensation after initial application of Frason ointment.
Acne Vulgaris ; Betamethasone ; Dermatitis, Atopic ; Dermatitis, Contact ; Dermatitis, Seborrheic ; Eczema ; Folliculitis ; Framycetin ; Gentamicins ; Humans ; Pityriasis Rosea ; Psoriasis ; Sensation ; Skin Diseases

Epidermal nevus syndrome, which used to combine congenital abnormalities of the central nervous and skeletal system and others, are not ingrequently encountered. Until now fer cases of epidermal nevus with intemal malignancy were reported in the literatures, Since the report on this epidermal nevus associated with intemal malignancy, the newer finding was interested by dermatologist. A case of 3 and half months old boy who had nevus unius lateris and retroperitoneal leiomyosarcoma since at birth was seen at St. Mart's Hospital. He did not mongolian and cafe au lait spots on the vack which seemed to be a characteristicaign of epidermal nevus syndrome, His developmenta percmtile was 25 of his matched age group. He was bome with spontaneous normal delibery in the hospital. His parents were relatively healthy and his morher had no history of any kind of medicine taken during the pregnancy. There were no family history of epidermal nevuys like skin lesions and hereditary disorders.
Cafe-au-Lait Spots ; Congenital Abnormalities ; Humans ; Leiomyosarcoma ; Male ; Nevus* ; Parents ; Parturition ; Pregnancy ; Skin

Characterizations of the VP4 (P type) and VP7 (G type) genes of Korean isolates of bovine rotavirus were performed using RT-PCR/RFLP and nucleotide sequencing analysis. After RT-PCR amplification of partial length (1094bp) of the VP4 and full length (1062bp) of the VP7 genes, amplified PCR products were digested with restriction endonucleases and digestion patterns were compared with those of reference rotaviruses. With the VP4 genes, four RFLP (AD) profiles were observed; three (A, B and C) were the same as those of bovine rotavirus NCDV (P[1]), IND (P[5]) and B223 (P[11]), respectively, Profile D was the same as that of porcine rotavirus OSU (p[7]). With the VP7 genes, five RFLP profiles (I-V) were observed; three of them (1, II and III) were the same as those of bovine rotavirus NCDV (G6), Cody I-801 (G8), and B223 (G10), respectively, Profile IV and V were atypical to those of reference bovine rotaviruses used in this study. These two profiles were identified as G6 and G5, respectively, after analyzing and comparing the nucleotide sequences. The G typing analysis revealed that 61.9% (26/42) were G6, which included G6 subtype; 28.6% (12/42) were G5; 7.1% (3/42) were G10; 2.4% (1/42) were G8. The P typing analysis revealed that 54.8% (23/42) were P(5); 28.6% (12/42) were P(7); 11.8% (5/42) were P(11); 4.8% (2/42) were P(1). Our results showed that G6/P(5) were the most prevalent rotaviruses in diarrheic calves in Korea. Also, this is the first report that G5P(7) rotaviruses were identified from cattle with diarrhea.
Animals ; Base Sequence ; Cattle ; Diarrhea ; Digestion ; DNA Restriction Enzymes ; Korea ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length* ; Rotavirus*

We report a case of a 41-year-old female with acrogeria. She was in good health except for the prominent atrophy over the hands and feet. On microscopic examination of a biopsy specimen from the atropl6c skin, elastic fibers were clumped and fragmented. Electronmicroscopy revealed amorphous and granulous pseudoelastin, which is presumed to be consistent with acrogeria. Our patient had acro-osteolysis and an extra chromosome in addition to the normal 23 pairs of chromosomes in one of 20 cells examined, which have been very rarely reported in the literature. Further studies are needed to find out whether this chromosomal aberration might contribute to the pathogenesis.
Acro-Osteolysis ; Adult ; Atrophy ; Biopsy ; Chromosome Aberrations ; Elastic Tissue ; Female ; Foot ; Hand ; Humans ; Skin

Impaired sweating reportedly has been associated with a high incidence of heat pyrexia. An important cause is attributed to sweat gland fatigue following intense prolonged sweating. For further investigation, sweat gland fatigue was induced by heat exposure for 2 hours in a hot room (dry bulb 46c, wet bulb 37c) with 9 healthy subjects. Sweating rate of the right forearm increased progressively for the first 45 minutes with a maximum value of 40.0mg/4. 91 cm2/15 min followed by a slow decrease to 24.9 mg/4.91cm2/15 min at the end of 2 hours. Active sweat pores decreased in number following 2 hours of heat exposure but the differences were not significant statistically. In spite of the higher sweat rate on the back, the number of active sweat pores was smaller as compared to the right forearm. Na+ concentrations of the second hour sweat collections were higher than those of the first hour with difference of 14. 9 mEq/l on the right forearm and 12.3 mEq/1 on the back.
Fatigue ; Fever ; Forearm ; Hot Temperature* ; Incidence ; Sweat Glands ; Sweat* ; Sweating

Puraotix-C(0.1% Clocortolone Picalats Cream) is a new di-halogenated topical corticosteroid, and used in trial for treating several kinds of dermatoses. We treated 30 patients with Purantix-C who had one of the following dermatoses; atopic dermatitis, neurodermatitis, pustulosis palmaris et plantsris, seborrheic dermatitis, pityriasis rosea, nummular eczema, psoriasis vulgaris, pruritus ani and pompolyx. Among these 30 patients, Purantix-C showed excellent or good result (66.7%) either unoccluded or occluded application, 2~3 times daily for 7~10 days. Comparing with Lidex(0.05% fluorocinonide cream) and purantix-C, both of them had similar effect on eczema and psoriatic groups but Lidex was more effective than Purantix-C for treating the patients with the pustulosis palmaris et plantaris. Purantix-C without containing perfume and coloring substapce was less irritative.
Dermatitis, Atopic ; Dermatitis, Seborrheic ; Eczema ; Fluocinonide ; Humans ; Neurodermatitis ; Perfume ; Pityriasis Rosea ; Pruritus Ani ; Psoriasis ; Skin Diseases

Multiple, reticulated, dark brown colored, macules and patches suddenly developed on the fac, and neck of a 48-year-old Korean woman two days after a traffic accident. On physical examination and laboratory tests including serum melanocyte-stimulating hormone, estrogen and progesterone level, no abnormalities were found except cervical pain. Histological examination of hematoxylin-eosin stained sections revealed increased melanin pigmentation in the basal layer, but the number of melanocytes was not changed in DOPA stained section. Topical application of 2% hydroquinone and 20% azelaic acid ointments had been applied successively for two months each without any apparent improvement. Herein we present a case of reticulate hyperpigmentation on the face and neck, which is very acute and whose causative factors are not certain.
Accidents, Traffic ; Dihydroxyphenylalanine ; Estrogens ; Female ; Humans ; Hyperpigmentation* ; Melanins ; Melanocytes ; Middle Aged ; Neck Pain ; Neck* ; Ointments ; Physical Examination ; Pigmentation ; Progesterone

No abstract available.
Schizophrenia*

Using atomic absorption spectrometry Pb, Cd, Cu, Zn and Fe were measured in sweat and Pb, Cd, Cu and Zn, in blood. The subjects were 22 healthy males, aged between 23-44. Sweating was induced with an environmental room (1 hour at 46C dry bulb and 36C wet bulb). Sweat samples were obtained from the left arm by the armbag technique. The sweat volume was 23.3+7.3ml(n= 22). The concentrations, in ug/ml, of trace elements in sweat were : lead, 0.18+0.17(n=22); cadmium, 0.006+0.006(n=22); copper, 0.37+0.66(n=10); zinc, 0.63+0.5(n=10); and iron, 0.22+0.12(n=10). The concentrations, in ug/ml, of trace elements in blood were : lead, 0.28+0.15(n=20); cadmium, 0.005+0.007 (n=20); copper,0.69+0.22(n=20); and zinc,5.61+0.86(n=20). These results clearly showed the significance of sweating as a route of excretion of trace element.
Absorption ; Arm ; Cadmium ; Copper ; Humans ; Iron ; Male ; Spectrum Analysis ; Sweat* ; Sweating ; Trace Elements ; Zinc