Along with psychosocial factors of suicide, biological backgrounds of suicide are explored by extensive works mostly on biological markers, neurobiological models, genetic bases, and relationship with aggression and violence. The biology of suicide confers on neurotransmitters in central nervous system exploring metabolites, receptor binding affinities, neuroen-docrine challenge tests in brain, cerebrospinal fluid, blood and etc. The major concerns with suicide are focused mainly on serotomin system: low CSF-5-HIAA concentration, higher 5-HT2 receptor binding, and blunt prolactin response to fenfluramine. Postmortem study, in vivo study, genetic contributions, and some other issues such as suicidal methods, serum cholesteral, alcohol, and selective serotonin reuptake inhibitors are reviewed and discussed.
Aggression ; Biomarkers ; Biology ; Brain ; Central Nervous System ; Cerebrospinal Fluid ; Fenfluramine ; Models, Genetic ; Neurotransmitter Agents ; Pathology* ; Prolactin ; Psychology ; Serotonin Uptake Inhibitors ; Serotonin* ; Suicide* ; Violence*

No abstract available.
Hepatitis B virus* ; Hepatitis B* ; Hepatitis* ; Korea*

Indications of reverse total shoulder arthroplasty (RTSA) have been consistently extended by technical advancements in reverse arthroplasty prosthesis, continuous development of the implants, accumulated experiences and its successful treatment outcomes; accordingly, its use has rapidly increased. RTSA has been performed for a variety of indications, with variable outcomes depending on the initial diagnosis. However, controversial opinions still exist regarding the design of reverse arthroplasty prosthesis (medialized or lateralized design and the neck-shaft angle of the humeral prosthesis), suture of the subscapularis tendon, use of cement during placement of the humeral prosthesis, and surgical procedures; therefore, these should be investigated so that they can be better understood.
Arthroplasty* ; Diagnosis ; Prostheses and Implants ; Shoulder* ; Sutures ; Tendons

Although arthroscopic surgery has been used conventionally, it has not been widely adopted yet due to the risks of complications, including nerve damage, technical difficulties, and limited indications. As shown in other joints, however, the use of an arthroscope will gradually increased in the elbow joint (‘Arthroscopy always wins’). Herein, arthroscopic treatments and arthroscopic ulnar nerve decompression will be discussed in cases of elbow osteoarthritis.
Arthroscopes ; Arthroscopy ; Decompression* ; Elbow Joint ; Elbow* ; Joints ; Osteoarthritis* ; Ulnar Nerve*

A case of Peutz-Jeghers syndrome was experienced with melanin pigmentation in the oral cavity and lips associated small intestine polyposis. Diagnosis of Peutz-Jeghers syndrome was established by clinical characteristics of skin and X-ray studies of gastrointestinal tracts.
Diagnosis ; Gastrointestinal Tract ; Intestine, Small ; Lip ; Melanins ; Mouth ; Peutz-Jeghers Syndrome* ; Pigmentation ; Skin

The pharmacotherapy of schizophrenia exhibit wide inter-individual variabilities in clinical efficacy and adverse effects. Recently. human genetic diversity has been known as one of the essential factors to the variation in human drug response. This suggests that drug therapy should be tailored to the genetic characteristics of the individual. Pharmacogenetics is the field of investigation that attempts to elucidate genetic basis of an individual's responses to pharmacotherapy, considering drug effects divided into two categories as pharmacokinetics and pharmacodynamics. The emerging field of pharmacogenomics. which focuses on genetic determinants of drug response at the level of the entire human genome, is important for development and prescription of safer and more effective individually tailored drugs and will aid in understanding how genetics influence drug response. In schizophrenia, pharmacogenetic studies have shown the role of genetic variants of the cytochrome P450 enzymes such as CYP2D6, CYP2C19, and CYP2A1 in the metabolism of antipsychotic drugs. At the level of drug targets, variants of the dopamine D_(2), D_(3) and D_(4), and 5-HT_(2A) and 5-HT(2C) receptors have been examined. The pharmacogenetic studies in schizophrenia presently shows controversial findings which may be related to the multiple involvement of genes with relatively small effects and to the lack of standardized phenotypes. For further development in the pharmacogenomics of schizophrenia, there would be required the extensive outcome measures and definitious, and the powerful new tools of genomics, proteomics and so on.
Antipsychotic Agents ; Cytochrome P-450 CYP2D6 ; Cytochrome P-450 Enzyme System ; Dopamine ; Drug Therapy ; Genetic Variation ; Genetics ; Genome, Human ; Genomics ; Humans ; Metabolism ; Outcome Assessment (Health Care) ; Pharmacogenetics* ; Pharmacokinetics ; Phenotype ; Prescriptions ; Proteomics ; Receptor, Serotonin, 5-HT2C ; Receptors, Dopamine ; Schizophrenia*

No abstract available.

Characterizations of the VP4 (P type) and VP7 (G type) genes of Korean isolates of bovine rotavirus were performed using RT-PCR/RFLP and nucleotide sequencing analysis. After RT-PCR amplification of partial length (1094bp) of the VP4 and full length (1062bp) of the VP7 genes, amplified PCR products were digested with restriction endonucleases and digestion patterns were compared with those of reference rotaviruses. With the VP4 genes, four RFLP (AD) profiles were observed; three (A, B and C) were the same as those of bovine rotavirus NCDV (P[1]), IND (P[5]) and B223 (P[11]), respectively, Profile D was the same as that of porcine rotavirus OSU (p[7]). With the VP7 genes, five RFLP profiles (I-V) were observed; three of them (1, II and III) were the same as those of bovine rotavirus NCDV (G6), Cody I-801 (G8), and B223 (G10), respectively, Profile IV and V were atypical to those of reference bovine rotaviruses used in this study. These two profiles were identified as G6 and G5, respectively, after analyzing and comparing the nucleotide sequences. The G typing analysis revealed that 61.9% (26/42) were G6, which included G6 subtype; 28.6% (12/42) were G5; 7.1% (3/42) were G10; 2.4% (1/42) were G8. The P typing analysis revealed that 54.8% (23/42) were P(5); 28.6% (12/42) were P(7); 11.8% (5/42) were P(11); 4.8% (2/42) were P(1). Our results showed that G6/P(5) were the most prevalent rotaviruses in diarrheic calves in Korea. Also, this is the first report that G5P(7) rotaviruses were identified from cattle with diarrhea.
Animals ; Base Sequence ; Cattle ; Diarrhea ; Digestion ; DNA Restriction Enzymes ; Korea ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length* ; Rotavirus*

No abstract available.
Drug Therapy*

The purpose of this study was to investigate the functional recovery of end-to-side neurorrhaphy in rats. There have been several studies about the results of end-to-side neurorrhaphy from a histologic or eletrophysiologic view point. However, histologic or electrophysiologic parameters may not correlate with the actual nerve function. In this study we assessed the results of end-to-side neurorrhaphy functionally using walking track analysis. Forty-eight male Sprague-Dawley rats were randomly divided into 4 group, with 12 rats in each group. Group 1 was the sham-operation group. Group 2 was the peroneal nerve transection group. In group 3, the peroneal nerve was severed and end-to-end neurorrhaphy was carried out. In group 4, the peroneal nerve was severed and coapted end-to-side to the lateral face of the tibial nerve after removal of the epineurium arid perineurium. Walking track analysis was done every 2 weeks up to 16 weeks. Group 3 recovered 80.4% in peroneal function at postoperative 16 weeks, whereas group 4 recovered only 46.0%. In group 2, it was impossible to measure the peroneal function by walking track analysis because of plantar flexion contracture after 6 weeks. We concluded that the end-to-side neurorrhaphy group showed better results compared with the nerve transection group. However, the end-to-end neurorrhaphy group showed still better results in the walking track analysis of rats.
Animals ; Contracture ; Humans ; Male ; Peripheral Nerves ; Peroneal Nerve ; Rats* ; Rats, Sprague-Dawley ; Tibial Nerve ; Walking*