1.Study on follicular fluid steroid concentration according to success of in vitro fertilization.
Hyung Bae PARK ; Kyung Sook CHO ; Chung Soon BACK ; Jae Myung KIM ; Sun Kyung LEE ; Byung Hee SHU ; Jae Hyun LEE
Korean Journal of Obstetrics and Gynecology 1991;34(4):537-553
No abstract available.
Female
;
Fertilization in Vitro*
;
Follicular Fluid*
2.Decreased Hepatic Nerve Fiber Innervation in Patients with Liver Cirrhosis.
Soon Woo NAM ; Hyun Joo SONG ; Su Jung BACK ; Tae Hun KIM ; Se Hyun CHO ; Joon Yeol HAN ; Kwon YOO ; Young Suk LEE ; Kyu Won CHUNG
Gut and Liver 2007;1(2):165-170
BACKGROUND/AIMS: Hepatic nerve innervation plays important roles in hepatic metabolism and hemodynamic mechanisms. We compared the distribution patterns of hepatic nerves between normal livers and two liver diseases to elucidate the effects of liver disease on the distribution of hepatic nerves. METHODS: Tissue specimens were obtained by ultrasonography-guided needle biopsies from 10 normal controls, 74 patients with chronic hepatitis (CH), and 35 patients with liver cirrhosis (LC). The obtained specimens were immunohistochemically stained using antibodies for S-100 protein and alpha-smooth-muscle actin (alpha-SMA). The degree of the expression in liver tissues was quantified by manual counting of positively stained nerve fibers under light microscopy. The serum hyaluronic acid level was assayed in all subjects to evaluate hepatic fibrosis. Electron microscopy examinations were also performed. RESULTS: The hepatic nerve innervation was significantly lower in LC than in normal controls, as indicated by S-100 protein staining. alpha-SMA and hyaluronic acid levels were higher in LC and CH than in normal controls. Electron microscopy revealed that unmyelinated nerve fiber bundles in the intralobar connective tissue coursed in the vicinity of hepatic triads. CONCLUSIONS: These results suggest that hepatic nerve innervation can be decreased by hepatic inflammatory responses and/or fibrotic changes in LC patients. Further study is needed to clarify this observation.
Actins
;
Antibodies
;
Biopsy, Needle
;
Connective Tissue
;
Fibrosis
;
Hemodynamics
;
Hepatitis, Chronic
;
Humans
;
Hyaluronic Acid
;
Liver Cirrhosis*
;
Liver Diseases
;
Liver*
;
Metabolism
;
Microscopy
;
Microscopy, Electron
;
Nerve Fibers*
;
Nerve Fibers, Unmyelinated
;
S100 Proteins
3.Clinical and hematologic manifestations in patients with Diamond Blackfan anemia in Korea.
Soon Ki KIM ; Hyo Seop AHN ; Hee Jo BACK ; Bin CHO ; Eun Jin CHOI ; Nak Gyun CHUNG ; Pyoung Han HWANG ; Dae Chul JEOUNG ; Hyung Jin KANG ; Hyery KIM ; Kyung Nam KO ; Hong Hoe KOO ; Hoon KOOK ; Kwang Chul LEE ; Ho Joon LIM ; Young Tak LIM ; Chuhl Joo LYU ; Jun Eun PARK ; Kyung Duk PARK ; Sang Kyu PARK ; Kyung Ha RYU ; Jong Jin SEO ; Hee Young SHIN ; Ki Woong SUNG ; Eun Sun YOO
Korean Journal of Hematology 2012;47(2):131-135
BACKGROUND: Diamond Blackfan anemia (DBA), characterized by impaired red cell production, is a rare condition that is usually symptomatic in early infancy. The purpose of this study was to assess nationwide experiences of DBA encountered over a period of 20 years. METHODS: The medical records of 56 patients diagnosed with DBA were retrospectively reviewed from November 1984 to July 2010. Fifteen institutions, including 13 university hospitals, participated in this study. RESULTS: The male-to-female ratio of patients with DBA was 1.67:1. The median age of diagnosis was 4 months, and 74.1% were diagnosed before 1 year of age. From 2000 to 2009, annual incidence was 6.6 cases per million. Excluding growth retardation, 38.2% showed congenital defects: thumb deformities, ptosis, coarctation of aorta, ventricular septal defect, strabismus, etc. The mean hemoglobin concentration was 5.1+/-1.9 g/dL, mean corpuscular volume was 93.4+/-11.6 fL, and mean number of reticulocytes was 19,700/mm3. The mean cellularity of bone marrow was 75%, with myeloid:erythroid ratio of 20.4:1. After remission, 48.9% of patients did not need further steroids. Five patients with DBA who received hematopoietic transplantation have survived. Cancer developed in 2 cases (3.6%). CONCLUSION: The incidence of DBA is similar to data already published, but our study had a male predilection. Although all patients responded to initial treatment with steroids, about half needed further steroids after remission. It is necessary to collect further data, including information regarding management pathways, from nationwide DBA registries, along with data on molecular analyses.
Anemia
;
Anemia, Diamond-Blackfan
;
Aortic Coarctation
;
Bone Marrow
;
Congenital Abnormalities
;
Diamond
;
Erythrocyte Indices
;
Heart Septal Defects, Ventricular
;
Hemoglobins
;
Hospitals, University
;
Humans
;
Incidence
;
Korea
;
Male
;
Medical Records
;
Registries
;
Reticulocytes
;
Retrospective Studies
;
Steroids
;
Strabismus
;
Thumb
;
Transplants