Primary non-Hodgkin's lymphoma of the lung is rare among extranodal lymphomas. The most common form is low grade B-cell type originated from the mucosa-associated lymphoid tissue (MALT) of the lung and primary peripheral T cell lymphoma of the lung is extremely rare. We recently experienced a case of fine needle aspiration cytology of primary peripheral T cell lymphoma of the lung in a 39-year-old male patient. The cytologic smears revealed some sheets of reactive epithelial cells, epithelioid histiocytes, and numerous polymorphous population of lymphoid cells composed of small and intermediate sized lymphoid cells and mature lymphocytes. Lymphoid cells were slightly larger than normal mature lymphocytes and showed significant irregularity of nuclear membrane. The internal nuclear structure was marked by chromatin clumping, clear parachromatin areas, and inconspicuous nucleoli. Histopathologically, atypical small lymphocytes infiltrated in the interstitium and alveolar sac. By the immunohistochemical study and molecular biologic study of gene rearrangement, the T cell clonality of atypical lymphoid cells was confirmed. Key words: Peripheral T cell lymphoma, Lung, FNAC
Adolescent* ; Adult ; B-Lymphocytes ; Biopsy, Fine-Needle ; Carcinoma, Medullary ; Chromatin ; Epithelial Cells ; Gene Rearrangement ; Histiocytes ; Humans ; Lung ; Lymphocytes ; Lymphoid Tissue ; Lymphoma ; Lymphoma, Non-Hodgkin ; Lymphoma, T-Cell, Peripheral ; Male ; Nephrosis, Lipoid* ; Nuclear Envelope ; Thyroid Gland

Disc herniation is commonly thought to be disease of young and middle aged adult and the backache during adolescence and childhood frequently mislead the doctor to suspect other conditions such as epiphysitis, spondylolysis, and infection of vertebral column, etc. During the period of 1967~1977, 26 cases of juvenile disc herniation were collected at Catholic Medical College and the authors analysed these cases and the results are as follows. 1. The incidence was 3.4% of all disc herniation. 2. There was no sex predilection. 3. The clinical symptoms do not differ from that of the adult cases, but sensory disturbance and motor weakness appear less frequently. 4. Good result was obtained after the surgical removal of the involved disc. 5. The etiology of the disc herniation in childhood and adolescence is thought to be superimpositon of trauma over the preceding degenerative changes in disc.
Adolescent ; Adult ; Back Pain ; Humans ; Incidence ; Middle Aged ; Spine ; Spondylolysis

The purpose of this study is to present quantitative data showing the relationship between visual acuity and refractive error in the various types of myopia: simple myopia, simple myopic astigmatism and compound myopic astigmatism. 1. The study covered 681 patient (1259 eyes) examined by having refractive error in myopia. (-0.25 ~ -20.00D) the Department of Ophthalmology, Yonsei University Medical Center and Wonju Christian Hospital. 2. Plotting the logarithm of visual acuity on the logarithm of the degree of myopia gives a coefficient correlation of -0.8028. The statistical data showed significant in correlation coefficient (r) in various types of myopIa: simple myopia r=-0.7789(p=0.001), simple myopic astigmatism r=-0.7877(p=0.001), compound myopic astigmatism r=-0.7537(p=0.001). 3. The coefficient of determination (R2) was 0.6445. 4. The mathematical mean of the various types of myopia: a. myopIa; simple myopia: 0.29(=20/60), simple myopic astigmatism: 0.87(=20/25), compound myopic astigmatism: 0.29(=20/60). b. visual acuity; simple myopia: -2.53D, simple myopic astigmatism: -0.50D, compound myopic astigmatism: -3.04D. 5. The formulas for the two regression line were: log V=-0.7385 log M-0.4976 (A)(F=2175.7303, p=0.001), log M= -0.8727 log V -0.3641 (B)(F=2175.7303, p=0.001). 6. Confidence limits were determined for the regression lines and table and set up for predicting either the degree of myopia or the visual acuity if the other is known.
Academic Medical Centers ; Astigmatism ; Gangwon-do ; Humans ; Myopia* ; Ophthalmology ; Refractive Errors* ; Visual Acuity*

The authors reviewed forty cases of acoustic neurinomas operated on from July 1974 to June 1984, analyzing our data obtained during 10 years in the following three periods: 1974 to 1978, 1978 to 1981, 1981 to 1984. A suboccipital approach was used for the removal of acoustic neurinomas in all cases. 1) A peak in the age distribution was seen at 40-50 years of age and no sexual difference was present. 2) The earliest symptoms were hearing loss(50%), headaches(25%), tinnitus(15%) in order of frequency. The time between onset of complaints and admission was mostly within 5 years(83%). 3) Most of the patients had large tumors(78%), greater than 3cm, of whom 4 patients were free of cerebellar and brain stem dysfunction. 4) Total removal was carried out in 27 out of 40 patients(67%) and particularly in 8 out of 14 patients(57%) with large tumors greater than 5cm. The total mortality was 7.5%. 5) In the last 3 years with the advance of microsurgical technique and CT scan, 25 patients were operated on only with a single death and total removal was carried out in 20 out of 25 patients. 6) In total removal, the total mortality was 7.4% and the mortality was 8% in patients with 3-5cm sized tumors and 13% in patients with tumors greater than 5cm, particularly 5% in the recent 3 years. 7) Preservation of the facial nerve following total removal was achieved in 59%. In the recent 3 years, the facial nerve was preserved in 65%. In the large tumors, 3-5cm sized and greater than 5cm, the rates of 75% and 37% were obtained.
Acoustics* ; Age Distribution ; Brain Stem ; Facial Nerve ; Hearing ; Humans ; Mortality ; Neuroma, Acoustic* ; Tomography, X-Ray Computed

No abstract available.
Glycogen Storage Disease Type I*

It is well established that mast cell proliferation and maturation are regulated by two principle cytokines, IL-3 and the c-kit ligand stem cell factor (SCF). Previous reports have demonstrated that bone marrow-derived IL-3-dependent mast cells exhibit the characteristic apoptosis on removal of IL-3. To know how the number of mast cells is controlled, we observed the effects of nitric oxide (NO) on the murine bone marrow-derived cultured mast cells (BMCMC). Apoptosis was measured by the analysis of flow cytometric data and electrophoretic evidence of DNA fragmentation. Our data showed that sodiurn nitroprusside (SNP)-a NO releasing substance- induced apoptosis in BMCMC. Cell cycle analysis showed that the number of the G,/G, and S phase decreased markedly, while the percentage of cell in G,/M phase was increased. Also, SNP alone induced cell death, whereas SNP in combination with SCF markedly decreased cell death of BMCMC. SNP-induced apoptosis was partially inhibited by the treatment of BMCMC with SCF. Our results suggest that NO might have sorne role in the regulation of the number of mast cells.
Apoptosis ; Bone Marrow* ; Cell Cycle ; Cell Death ; Cytokines ; DNA Fragmentation ; Interleukin-3 ; Mast Cells* ; Nitric Oxide* ; Nitroprusside ; S Phase ; Stem Cell Factor

Hereditary macular degeneration is characterized by bilateral degenerative changes in the macular area without a simultaneous degeneration in the central nervous system. This hereditary macular degeneration was first described by Rayner Battern in 1897. Since then, not only this degeneration but also many other types of hereditary macular degeneration have been described. In 1940, Behr classified macular degeneration into six types: Infantile, Juvenile, Adolescent, Adult, Presenile, Senile types. In 1973, Hughes classified this degeneration, by electro-and psychophysiologic evidence, as; 1) Progressive cone degeneration mainly affecting the photoreceptors; 2) Stargardt's disease or fundus flavimacultus type II; 3) Best's disease or vitelliform degeneration probably affecting primarily the basal portion of the pigment epithelium cells; 4) Doyne's or hereditary drusen affecting Bruch's membrane; and 5) Central choroid sclerosis affecting the choriocapillaries. Upon reviewing the literatures relating to this disease, two case reports have been included here of hereditary macular degeneration without apparent cause which involved a brother and sister of one family.
Adolescent ; Adult ; Bruch Membrane ; Central Nervous System ; Choroid ; Epithelium ; Humans ; Macular Degeneration* ; Sclerosis ; Siblings* ; Vitelliform Macular Dystrophy

Left ventricular hypertrophy is a compensatory response to hemodynamic overload secondary to an increased systemic resistance. This increase, however, is not the only cause of hypertrophy, and there are other factors which can have a significant effect on its incidence. To determine whether chronic antihypertensive therapy by enalapril modifies the cellular and subcellular changes of left ventricular hypertrophy observed in spontaneously hypertensive rats(SHR), 20-weeks-old SHR were treated for 22 weeks with enalapril(2mg/kg) and compared with normotensive Wister-Kyoto rats and not-treated SHR. Systolic blood pressure in enalapril-treated SHR was significantly lowered after 22 weeks compared with that of untreated control SHR group. Myocytes were reduced in size and fibrination seen in cardiac muscle fibers of control SHR was decreased in treated SHR group. Myofibrils appeared to be irregular in shape and myofilaments are decreased in control SHR but in enalapril-treated SHR the diameter and length of the myofilament became turned to regular forms. These results suggest that, enalapril, angiotensin converting enzyme inhibitor, may regress hypertrophy and some subcellular changes may be modified by enalapril.
Animals ; Blood Pressure ; Enalapril* ; Fibrin ; Hemodynamics ; Hypertrophy ; Hypertrophy, Left Ventricular* ; Incidence ; Muscle Cells ; Myocardium ; Myofibrils ; Peptidyl-Dipeptidase A ; Rats ; Rats, Inbred SHR*

Legg-Calve-Perthes disease is self-limited, but its course may result in irreversible mechanical impairment of the hip. The clinical observation and analysis were carried out on 83 cases of Legg-Calve-Perthes disease in the Department of Orthopaedic Surgery, Presbyterian Hospital, Taegu.
Daegu ; Hip ; Legg-Calve-Perthes Disease ; Protestantism

The number of spinal injuries are now increasing with the high speed of automobile and industrial development. It is a general trend to treat the spinal injuries more actively in recent years, Among 135 spinal injury patients who were admitted to this hospital from August 1,1972 to August 31,1978, twenty six cases of spine fractures and fracture-dislocations who was treated with surgical measures were evaluated and analysed. Short summary of the followings observed is as follows: 1. Out of 26 patients, there were 22 male and 4 female cases. The ratio between male and female was 5.5:1. The majority (16 cases, 62%) was found in the age group of 20 to 40 years. 55.4% of the cases was caused by traffic accident. 2. The most common site of the lesion was cervical spine (9 cases, 35%) and the most common mechanism of injury was flexion and rotation (10 cases, 38%). 3. Our surgical measures were mainly the early anatomical reduction and anterior and posterior spinal fusion followed by external immobilization. 4. Among 26 cases, 34% had complete paralysis and 31%, incomplete paralysis. Complete or partial recovery was observed in 22% of the completely paralysed cases and in 87% of the imcompletely paralysed cases. 5. The initial recovery of spinal cord injury was observed from 1 to 25 days postoperatively (average 15 days).
Accidents, Traffic ; Automobiles ; Clinical Study ; Female ; Humans ; Immobilization ; Industrial Development ; Male ; Paralysis ; Spinal Cord Injuries ; Spinal Fusion ; Spinal Injuries ; Spine