Solar urticaria is a fairly uncommon but Well recognized clinical entity characterized by erythema and wheal with itching immediately following exposure to sunlight or artifical radiation. A 33-year-old female had a six-year duration of urticaria, tightness of chest and dizziness that appeared within 15 minutes of exposure to sunlight. The action spectrum of this patient was between 320 and 400nm and the passive and reverse passive transfer test were negative. Solar urticaria of our patient appeared to belong to type g in the classification of Harber et al(1963). The patient was treated with antihistamines and repeated exposure to sunlight for inducing tolerance. After 3 months of the treatment, the symptoms did not appear even after 3 hours of exposure to sunlight.
Adult ; Classification ; Dizziness ; Erythema ; Female ; Histamine Antagonists ; Humans ; Intradermal Tests ; Pruritus ; Sunlight ; Thorax ; Urticaria*

No abstract available.
Child* ; Edema* ; Humans

No abstract available.
Pancreatic Pseudocyst*

No abstract available.
Ankle Fractures* ; Ankle*

Congenital dislocations of the hip are all present at birth. Therefore if adequate examination of all newborn infants is done regularly, it should theoretically never be seen in adolescents or adults. Both the pathogenesis and management of congenital dislocation of the hip remain controversial topics. Closed reduction of simple congenital dislocations of the hip with retention in frog position was introduced by Lorenz. After this great efforts to receive these patients for treatment as early as possible were made by investigators. Also numerous surgical procedures and modifications have been used. Congenital dislocations of the hip were known to be uncommon in Korea. Nevertheless adolescents with untreated dislocations were not rarely met. The author studied congenital dislocation of the hip for sex incidence, X-ray findings, birth history, relation with combining anomaly and the results of treatment, In this study, 39 cases of congenital dislocation of the hip, treated at the Orthopedic Department of Severance Hospital during 7 years and 6 months from July, 1970 until December, 1977, were reviewed. The results of this study are as follows: 1. The annual number of the patients who were treated at Severance Hospital has not changed markedly. 2. The number of female patients was much greater than males. The ratio of female to male was 9 to 1. 3. The incidence of bilateral involvement was relatively low compared to the western coutries. 4. Congenital anomaly associated with congenital dislocation of hip occurred in about 7.8%. 5. The acetsbular index, C-E angle, Y-coordinate and height on affected hips are aggrevated according to the increment of age. 6. Closed reduction was satiafactory in 16 cases among 22 cases under the age of 3, but 4 cases were treated by operation. 7. Open reduction was performed in 8 cases, Salter's innominate osteotomy in 8 cases, Colonna's capsular arthroplasty in 2 cases, and supracondylar osteotomy in 2 cases.
Adolescent ; Adult ; Arthroplasty ; Clinical Study ; Dislocations ; Female ; Hip ; Humans ; Incidence ; Infant, Newborn ; Korea ; Male ; Orthopedics ; Osteotomy ; Parturition ; Reproductive History ; Research Personnel

There exists a need to develop strategies that promote neovascularization in virtually all tissue engineering and regenerative medicine efforts. While research typically focuses on understanding and exploiting the role of angiogenic factors and vascular cells on new blood vessel formation, the activity of the immune system is being recognized to impact vascular formation and adaptation. This review will provide both an overview of the relationship of angiogenesis and the immune system, and how biomaterials may be designed to promote favorable angiogenesis by interaction between these 2 systems to promote effective vascularization.
Angiogenesis Inducing Agents ; Biocompatible Materials ; Blood Vessels ; Immune System ; Inflammation* ; Regenerative Medicine ; Tissue Engineering

PURPOSE: The present study was performed to determine the optimum conditions(RPM, load, sharpness of drill) for drilling human cortical bone with standard drill, and to evaluate the histological changes occuring in bone after drilling. MATERIALS AND METHODS: in experiment I, we measured temperature elevations and the durations of temperature elevation in cadaveric femoral cortices at specific distances from the drill hole wall while drilling. The effects of drilling force, speed and new versus worn drill on the termperature were determined. In experiment II, we also measured temperature elevations in the same manner in porcine femoral cortices and evaluated the histological changes occuring in bone after drilling. RESULTS: In experiment I, the most significant temperature elevation(68.4degrees C ) was found when worn drill was used. The lower drilling force and faster speed resulted in 55.1degrees C and 45.8degrees C temperature elevation, respectively. However, drill diameter was not a significant factor for temperature elevation. In experiment II, greater heat production was measured with worn drill, at lower drilling forces, at faster drill speed. The acute histologic reactions in bone were hyperemia, degeneration of osteocytes, change in bone stainability, tears, and fragmentation of the bone edges around the drill holes. The observed histological changes were proportional to the amount of trauma produced, that is, the greater the degree of thermal irritation, the greater the degree of histologic activity. CONCLUSION: In cortical drilling, greater heat production was measured with worn drill, at lower drilling forces, at faster drill speed and the greater the degree of thermal irritation, the greater the degree of histologic activity. A further study of the reaction of bone to drilling at longer intervals of time at different conditions may possibly show whether aseptic thermal necrosis could be prevented.
Cadaver ; Hot Temperature* ; Humans ; Hyperemia ; Necrosis* ; Osteocytes ; Thermogenesis*

Necrotizing fasciitis is a life-threatening, invasive soft-tissue infection that is characterized by widespread, rapidly developing necrosis of the subcutaneous tissue and fascia with relative sparing of the skin and underlying muscle. In type I necrotizing fasciitis, anaerobes and gram negative bacteria are predominant; in the type II form, Group A p-hemolytic streptococcus is a major etiologic agent. It needs immediate surgical intervention for a favorable outcome. A 64-year-old male presented with extremely painful, erythematous, symmetric, tense swelling with yellowish or hemorrhagic blisters on his right upper extremity. Two weeks before the admission, pain on his elbow made him take acupuncture therapy, There was severe tenderness, pitting edema, and his right elbow showed limited flexibility. The patient underwent wide debridement and drainage immediately. Liquefactive necrosis was seen in the subcutaneous fat and superficial fascia without muscular involvement. Group A B-hemolytic streptococci were grown from the tissue culture specimen.
Acupuncture Therapy ; Blister ; Debridement ; Drainage ; Edema ; Elbow ; Fascia ; Fasciitis, Necrotizing* ; Gram-Negative Bacteria ; Humans ; Male ; Middle Aged ; Necrosis ; Pliability ; Skin ; Streptococcus ; Subcutaneous Fat ; Subcutaneous Tissue ; Transcutaneous Electric Nerve Stimulation ; Upper Extremity

Intravesical instillation of Mycobacterium bovis bacille Calmette–Guérin (BCG) has been used for treating nonmuscle invasive bladder cancer as the forefront of immunotherapy, but BCG is ineffective in approximately 30–40% of cases and disease recurs in up to 50% of patients. Recently BCG is considered an effective vehicle for delivery of antigens due to its unique characteristics, and the genetic control of these mycobacteria is advanced in the search for less toxic and more potent therapeutic agents for bladder cancer immunotherapy. We will discuss current advances in recombinant BCG construction, research, and future directions.
Administration, Intravesical ; BCG Vaccine ; Humans ; Immunotherapy* ; Mycobacterium bovis ; Urinary Bladder Neoplasms* ; Urinary Bladder*

With the emergence of microbiome as a major player in many human diseases, bacteria as therapeutics are gaining significant interest. Whole bacteria or cytotoxic or immunogenic peptides carried by them exert potent anti-tumor effects in the experimental models of cancer. The use of attenuated microorganism (s) e.g., BCG to treat human urinary bladder cancer was found to be superior compared to standard chemotherapy. While bacteria alone may not offer full therapeutic benefits, modifying them with anti-tumor agents, anti-oncogenes or immunogenic antigens, either alone or in combination, will prove to be beneficial. Vectors for delivering shRNAs that target oncogenic products, express tumor suppressor genes and immunogenic proteins have been developed. These approaches have showed promising anti-tumor activity in mouse models against various tumors. These can be potential therapeutics for humans in the future and such therapeutics may become a future alternative or adjunct regimen along with conventional chemotherapy and radiotherapy. In this review, some conceptual and practical issues on how to improve these agents for human applications are discussed.
Animals ; Bacteria* ; Drug Therapy ; Genes, Tumor Suppressor ; Humans ; Mice ; Microbiota ; Models, Theoretical ; Mycobacterium bovis ; Peptides ; Radiotherapy ; RNA, Small Interfering ; Urinary Bladder Neoplasms