Tow cases of congenital ectodermal defect in brothers aged 15 and 10 years were pesinted and the literature was reviewed. They had lack of sweating, sparseness of the hard hairs, absence of lanugo hairs, maldevelopment or defect of most of the teeth, etc. They seemed to be angidrotic type associated with a sex-linked reccessive inheritance in their family backgroud.
Ectodermal Dysplasia* ; Hair ; Humans ; Siblings ; Sweat ; Sweating ; Tooth ; Wills

Holter ECG monitoring is a continuous tape recording of a patient's electrocardiogram during ordinary activities and picks up hidden abnormalities in rate, rhythm or conduction. The authors delineated the types and incidence rates of arrhythmia in 32 normal Koreans by utilizing medical personnels and patients without evident heart diseases or symptoms, or significant systemic illness. Tracings and analysis were performed using 24 hour Holter monitoring processor(SCM 240, Fukuda, japan), auto-analyser (SCM-25), casette recorder(SM 24) and chrome tape. Results are as follows: 1) Portable 24 houre Holter ECG monitoring was performed in 32 persons(age range of 21 to 35) without cardiovascular disease, as defined by normal clinical and noninvasive cardiovascular examination. 2) During exercise, maximal heart rates ranged from 125.0+/-12.1/min and minimal rates from 96.7+/-5.8/min. During normal activity period, maximal and minimal heart rates were, respectively, 95.4+/-16.2/min and 62.6+/-6.3/min. Maximal sleep rates were 90.3+/-26.6/min and minimal sleep rates 57.4+/-12.4/min. 3) P-R interval decreased as heart rate increased. Transient first degree AV block was noted in 3 subjects(9.4%) and Wenckebach type second degree AV block in 2 subjects(6.3%). 4) Sinus tachycardia and bradycardia were observed in all subjects and sinus arrhythmia was more frequently noted during waking periods. Three subjects had episodes of sinus pause with maximum duration of 3.24 seconds. 5) In 13 persons(40.6%) having supraventricular premature beats, the frequency was 50.01+/-49.36/hr and in 14 persons having(44%) ventricular premature beats the frequency 26.33+/-18.83/hr. Transient ventricular tachycardia of 3 seconds' duration was observed in one subject under the extreme stressful environment. 6) ST segment elevation over 1mm was noted in 5 subjects(15.6%), of whom one had a nocturnal chest pain and ST segment depression over 1mm in 2 subjects. T wave inversion was also found during exercise(3.1%) and during sleep(9.4%).
Arrhythmia, Sinus ; Arrhythmias, Cardiac ; Atrioventricular Block ; Bradycardia ; Cardiac Complexes, Premature ; Cardiovascular Diseases ; Chest Pain ; Depression ; Electrocardiography* ; Electrocardiography, Ambulatory ; Heart Diseases ; Heart Rate ; Humans ; Incidence ; Tachycardia, Sinus ; Tachycardia, Ventricular ; Tape Recording

No abstract available.
Blood Pressure* ; Child* ; Humans ; Seoul*

BACKGROUND: Paraquat, a widely used herbicide, is extremely toxic, causing multiple organ failure in humans. Paraquat especially leads to irreversible progressive pulmonary fibrosis, which is related to oxygen free radicals. However, its biochemical mechanism is not clear. Natural mechanisms that prevent damage from oxygen free radicals include changes in glutathione level, G6PDH, superoxide dismutase(SOD), catalase, and glutathione peroxidase. The authors think catalase is closely related to paraquat toxicity in the lungs METHOD: The effects of 3-amino-1,2,4-triazole(aminotriazole), a catalase inhibitor, on mice administered with paraquat were investigated. We studied the effects of aminotriazole on the survival of mice administered with paraquat, by comparing life spans between the group to which paraquat had been administered and the group to which a combination of paraquat and aminotriazole had been administered. We measured glutathion level, glucose 6-phosphate dehydrogenase(G6PDH), superoxide dismutase(SOD), catalase, and glutathione peroxidase(GPx) in the lung tissue of 4 groups of mice: the control grouts, group A(aminouiazole injected), group B(paraquat administered), group C(Paraquat and aminotriazole administered). RESULTS: The mortality of mice administered with paraquat which were treated with aminotriazole was significantly increased compared with those of mice not treated with aminotriazole. Glutathione level in group B was decreased by 20%, a significant decrease compared with the control group. However, this level was not changed by the administration of aminotriazole(group C). The activity of G6PDH in all groups was not significantly changed compared with the control group. The activities of SOD, catalase, and glutathione peroxidase(GPx) in the lung tissue were significantly decreased by paraquat administration(group B); catalase showed the largest decrease. Catalase and GPX were significantly decreased by aminotriazole treatment in mice administered with paraquat but change in SOD activity was not significant.(group C). CONCLUSION: Decrease in catalase activity by paraquat suggests that paraquat toxicity in the lungs is closely related to catalase activity. Paraquat toxicity in mice is enhanced by aminotriazole administration, and its result is related to the decrease of catalase activity rather than glutathione level in the lungs. Production of hydroxyl radicals, the most reactive oxygen metabolite, is accelerated due to increased hydrogen peroxide by catalase inhibition and the lung damage probably results from nonspecific tissue injury of hydroxyl radicals.
Amitrole* ; Animals ; Catalase ; Free Radicals ; Glucose ; Glutathione ; Glutathione Peroxidase ; Humans ; Hydrogen Peroxide ; Lung* ; Mice* ; Mortality ; Multiple Organ Failure ; Oxygen ; Paraquat* ; Pulmonary Fibrosis ; Superoxides

This study was undertaken to investigate the effect of superoxide dismutase(SOD) to sunburn cell production and development of UV-induced ear swelling reaction in mouse skin after ultraviolet irradiation. In this study, a total of 60 ICR female albino haired mice were used and divided into two groups, A(UVB: 150mJ/cm) and B(UVB:300mJ/cm). Groups of mice were injected intravenouly with SQD(300mJ,/1000cm) just befare UVR and after completion of UVR. The results were as follows . 1. The number of sunburn cells was significantly decreased by injection of SOD (300ug.1000ug)(p<0.05). 2. The number of sunburn cells in a group of mice which was given SOD 1000ug was significantly decreased more than in SOD 300pg(p<0.05). 3. Ear swelling reaction was not significantly suppressed by injection of SOD(300 Pa. 100SC)(p<0 05)
Animals ; Ear ; Female ; Hair ; Humans ; Mice* ; Skin* ; Sunburn* ; Superoxide Dismutase* ; Superoxides*

This study was aimed to clarify the effects of systemic kainic acid (KA) administration (10 mg/kg i.p.) on somatostatin containing neurons, and to examine the distribution of somatostain immunoreactive neurons in the cerebral cortex of the rats. Animals were sacrificed at three time points at the two, six, and ten days after the injection of KA. Thirty-six rats were observed by using the free-floating immunohistochemical method (modified ABC method). The results were as follows: 1) In the anterior and posterior cingulate cortex, somatostatin immunoreactive neurons were not observed in 2,6,10days after treatment of KA including control group except Cg 1 showing some somatostatin immunoreactive neurons in 10days and control groups. 2) In the insular cortex, somatostatin immunoreactive neurons also were not observed in any groups except AIV showing few somatostatin immunoreactive neurons in control group. 3) In the perirhinal cortex, few somatostatin immunoreactive neurons were observed in 2 days and 6 days groups. In control group, a number of somatostatin immunoreactive neurons observed. 4) A strong decrease of somatostatin immunoreactive neurons were observed in the frontal, arietal, temporal and occipital cortex 2 days after treatment of KA. Initially decreased somatostatin immunoreactive neurons had recovered to control 10 days after treatment. 5) Distribution of the somatostatin immunoreactive neurons was observed marked difference according to the cortical areas. Somatostatin immunoreactive neurons in isocortex were more increased in number than the allcotex by control study. The changes in somatostatin immunoreactive neurons after systemic treament of KA were marked in 2 days and 6 days, but these had recovered to control 10 days the treatment of KA. It suggested the normalization of the cerebral function 10 days after seizure. According to the cerebral cortex, the different distribution of somatostatin immunoreactive neurons in number was observed.
Animals ; Cerebral Cortex* ; Gyrus Cinguli ; Kainic Acid* ; Neurons* ; Rats* ; Seizures ; Somatostatin*

30 patients with essential hypertension were treated with diltiazem (Herben(R))significantly decreased both systolic and diastolic blood pressuer and heart rate. Mean decrease in systolic & diastolic blood pressuer were 38.0+/-4,5mmHg and 16.3+/-2.3 mmHg respectively and mean drop in heart rate was 17+/-2 beats/mm. The side effects of diltiazem (Herben(R)) were mild headache, fatigue and pruritus, but those were insignificant. Diliazem may be of benefit to hypertensive patients, and particularly useful when hypertension occurs in association with coronary artery disease.
Coronary Artery Disease ; Diltiazem* ; Fatigue ; Headache ; Heart Rate ; Humans ; Hypertension* ; Pruritus

The authors investigated serial changes of bacillary and granularity indices from 49 previously non-treated lepromatous leprosy patients under DDS therapy during 24 month period, and the following results were obtained. 1) Pretreatment bacillary index was highest on eye brows, and chins, ear lobes, arms, legs, backs in decreasing order. The proportion of fall of B.I. during therapy showed similar tendencies in each site of smears, the average decrease being 1. 2 in the first year and 0. 8 in the second year. 2) The average granularity index before therapy was 2. 5, the rise of G.I. was rapid during first 12 months, slower during next 6 months, and no significant changes were seen during last 6 months. 3) The changes of G.I. were faster and more sensitive to therapy than that of B.I. Therefore, it. seems more valuable assesing the response of therapy, drug resistance, prognosis, etc 4) 300 mg of DDS per week appears to be sufficient for maintaining the therapeutic dosage.
Arm ; Chin ; Drug Therapy ; Ear ; Equidae ; Humans ; Leg ; Leprosy, Lepromatous ; Mycobacterium* ; Prognosis

We observed the serum cholesterol, triglyceride and HDL-cholesterol values in 25 hyperlipidemic patients with procectofene(LIpanthyl(R))administration. 1) The mean serum lipids before & after procetofene administration was as follows 2) The undersirable effect of the drug was found on 3 patients; those were abdominal fullness, headache & pruritus.
Cholesterol* ; Fenofibrate ; Headache ; Humans ; Pruritus ; Triglycerides*

CT and myelography, separately or combined together, have been used for the study of spine lesion. Metrizamide enhanced CT is a new diagnostic modality for the study of spine lesion. The purpose of this study was to compare the efficacy of metrizamide enhanced CT with those of CT and metrizamide myelography. Among 163 surgically proven cases, metrizamide CT was carried out on 49 cases, CT on 50 cases and myelography on 64 cases, at Department of Orthopedic Surgery, Seoul University Hospital for 3 years period from August 1981 to July 1984. 1. Overall diagnostic accuracy of CT was 90%, that of metrizamide myelography was 82.8%and that of metrizamide CT was 93. 9%. 2. Diagnostic accuracy of metrizamide CT in HIVD was 95%, in spinal stenosis 94.4% and in spondylolisthesis 80%. 3. Most of complications were observed in myelography, even they were minor. 4. It was concluded that plain CT was advisable on a clinically typical HIVD, considering complications and expenses of myelography and metrizamide CT. 5. Metrizamide CT was indicated on previously operated cases or atypical HIVD, spinal stenosis and spondylolisthesis.
Metrizamide ; Myelography ; Orthopedics ; Seoul ; Spinal Stenosis ; Spine ; Spondylolisthesis