No abstract available.
Blood Donors* ; Hepacivirus* ; Hepatitis C* ; Hepatitis* ; Humans ; Incheon* ; Prevalence*

We report a case of a 41-year-old female with acrogeria. She was in good health except for the prominent atrophy over the hands and feet. On microscopic examination of a biopsy specimen from the atropl6c skin, elastic fibers were clumped and fragmented. Electronmicroscopy revealed amorphous and granulous pseudoelastin, which is presumed to be consistent with acrogeria. Our patient had acro-osteolysis and an extra chromosome in addition to the normal 23 pairs of chromosomes in one of 20 cells examined, which have been very rarely reported in the literature. Further studies are needed to find out whether this chromosomal aberration might contribute to the pathogenesis.
Acro-Osteolysis ; Adult ; Atrophy ; Biopsy ; Chromosome Aberrations ; Elastic Tissue ; Female ; Foot ; Hand ; Humans ; Skin

No abstract available.
Antibodies, Antiphospholipid* ; Autoimmune Diseases* ; Humans

No abstract available.
Antibodies, Antiphospholipid* ; Autoimmune Diseases* ; Humans

PURPOSE: To evaluate morphologic characteristics of the clustered microcalcifications in benign lesions and to compare with that of malignant lesions. MATERIALS AND METHODS: We retrospectively reviewed 33 patients with clustered microcalcifications( five calcifications in number per square centimeter)on mammography. We analyzed mammographic findings with regard to shape, size, number/cm2, irregularity of size and shape, presence of central lucency, and accompanied mass density. RESULTS: Of 12 benign lesions, the most frequent shape was dot or round form (4/12, 33.3%) followed by ring form (3/12, 25%). The size was smaller than 0.5mm in 5 patients (41.7%), 0.5-1 mm in one and more than 1 mm in 6 patients(50%). The number of calcifications per square centimeter were five to ten in 41.7%, more than ten in 58.3%. Of all 21 malignant lesions, the most frequent shape was branching form (8/21, 38.1%). The sizes of calcification were less than 0.5ram in 76.1%(16/21). Central lucency within the calcification was seen only in benign lesions (3/14, 21%). Irregularity ih size and shape of calcifictions was noted in both benign and malignant lesions. Accompanied parenchymal mass density was more commonly associated with malignant lesions(80. 9%) than benign lesions(58.3%). CONCLUSION: Our results suggest that benign clutered microcalcifications on mammography could be differentiated from malignant calcifications with the criteria of larger size, central lucency and infrequent accompanied mass.
Humans ; Mammography* ; Retrospective Studies

PURPOSE: To evaluate morphologic characteristics of the clustered microcalcifications in benign lesions and to compare with that of malignant lesions. MATERIALS AND METHODS: We retrospectively reviewed 33 patients with clustered microcalcifications( five calcifications in number per square centimeter)on mammography. We analyzed mammographic findings with regard to shape, size, number/cm2, irregularity of size and shape, presence of central lucency, and accompanied mass density. RESULTS: Of 12 benign lesions, the most frequent shape was dot or round form (4/12, 33.3%) followed by ring form (3/12, 25%). The size was smaller than 0.5mm in 5 patients (41.7%), 0.5-1 mm in one and more than 1 mm in 6 patients(50%). The number of calcifications per square centimeter were five to ten in 41.7%, more than ten in 58.3%. Of all 21 malignant lesions, the most frequent shape was branching form (8/21, 38.1%). The sizes of calcification were less than 0.5ram in 76.1%(16/21). Central lucency within the calcification was seen only in benign lesions (3/14, 21%). Irregularity ih size and shape of calcifictions was noted in both benign and malignant lesions. Accompanied parenchymal mass density was more commonly associated with malignant lesions(80. 9%) than benign lesions(58.3%). CONCLUSION: Our results suggest that benign clutered microcalcifications on mammography could be differentiated from malignant calcifications with the criteria of larger size, central lucency and infrequent accompanied mass.
Humans ; Mammography* ; Retrospective Studies

Percutaneous transluminal angioplasty(PTA) were performed in three patients with atherosclerotic stenosis of subclavian arteries. The arteries were successfully dilated without complications during the procedure. All patients were asymptomatic during follow-up periods ranging from eight months to fifteen months after PTA.
Angioplasty* ; Arteries ; Constriction, Pathologic ; Follow-Up Studies ; Humans ; Subclavian Artery*

Emphysematous pyelonephritis is rare but freuently fatal complication of renal parenchymal infection, mostcommonly occurs in diabetic patients and is often associated with urinary obstruction, prior urologicalabnormality or infection. From 1898 to 1984 , about 50 cases of empysematous pyelonephritis have been reporteduniversally. The diaignosis of emphysematous pyelonephritis can be made only roentgenographically. In the last 2years, we have had two cases of emphysematous pyelonephritis at our hospital. It is our purpose to report twopatients who have survived wtih a brief review of the previous literature.
Humans ; Pyelonephritis

BACKGROUND: Epstein-Barr virus(EBV)-specific Ab ELISA using recombinant antigens is the most widely used method in the diagnosis of EBV infection. Recently sensitivity and specificity were greatly improved. But still the early antigen(EA)-IgM is too sensitive for discriminating the true EBV infection from secondary reactivation by other infectious agents or autoimmune diseases. So we compared EBV-specific panel test with PCR genotyping. METHODS: We studied 944 patients in Yonsei University Medical College Hospital who were suspected to have EBV infection. EBV-specific Ab panel test including EA-IgM, EA-IgG, EBNA-IgG was performed and EBV PCR was also performed in 151 randomly selected patients. The test results were classified into 9 stages by optical density. EBNA 2 region was amplified by PCR using DNAs isolated from peripheral blood mononuclear cells. RESULTS: The seronegative rate was 9.9% given the EBV Ab panel results. Seronegative/primary infection was high in the pediatric group, past infection was high in the adult group, and reactivation was high in the ICU/transplanted group. The overall positive rate of EBV PCR in 151 patients was 35.8%, of which type 1 genotype was 55.6%, type 2 was 20.4%, and coinfection of type 1 and 2 was 24.1%. PCR results were all negative in seronegative group. PCR positive rates of primary infection and reactivation were high(41.7%, 43.5%, respectively). CONCLUSIONS: EBV Ab panel and EBV PCR showed good correlation. EBV panel test was useful in the screening and staging of EBV infection. EBV PCR genotyping was also needed in confirming and determining prognosis of EBV infection especially in an immunocompromised host.
Adult ; Autoimmune Diseases ; Coinfection ; Diagnosis* ; DNA ; Enzyme-Linked Immunosorbent Assay ; Epidemiology ; Epstein-Barr Virus Infections ; Genotype ; Herpesvirus 4, Human* ; Humans ; Immunocompromised Host ; Mass Screening ; Polymerase Chain Reaction* ; Prognosis ; Sensitivity and Specificity

Alpasia cutis congenita is an anomaly characterized by absence of localized areas of the integument. The most common type of aplasia cutis congenita is Aplasia cutis congenita limited to the scalp, although other areas of the body may also be involved. We experienced a case of aplasia cutis congenita in a male newborn infant. The skin defects were extensive with symmetrical involvement of lower extremities. The multiple bullae were found on the both fingers and toes. No similar conditions and other associated congeital anomalies were found in the family membes of this particular case. The light microscopic examinaton of the denuded skin areas how absence of epidemis and the demis contain atrophic and hypoplastic adnexa. The bullae have a split within the dermis below lamina densa on electron microscopy. The skin defects were healed by supportive therapy for 4weeks.
Dermis ; Ectodermal Dysplasia* ; Epidermolysis Bullosa* ; Fingers ; Humans ; Infant, Newborn ; Lower Extremity ; Male ; Microscopy, Electron ; Scalp ; Skin ; Toes