The lactic dehydrogenase activities of Ascaris lumbricoides have been assayed according to the developmental course of the fertilized eggs compared with the unfertilized eggs. Experimental procedures were modified that of Wroblewski and La Due's method with use of diphosphopyridine nucleotide reduced form(DPNH). Sodium pyruvate and lactic dehydrogenase, the specific activities were expressed as DPNH unit per mg protein by method of Kornberg's. The experimental results are as follaws: Lactic dehydrogenase activity in fertilized eggs of Ascaris are significantly increased from morula stage and its optimal pH is in 3.4 degrees. While any activities were not observed in unicell stage of fertilized eggs and unfertilized eggs. Water soluble protein of fertilized eggs of Ascaris were varied in their amount during their developmental process. The amont of protein in tadpole stage eggs have increased to 1.3 times more than that of cleavage stage eggs. However the amounts of water soluble protein in unfertilized eggs are revealed to one-third less than that of fertlized eggs. The specific activity of lactic dehydrogenase in tadpole stage eggs are decreased to one third less than those of morula stage eggs during development, the stage is considered to be as a growth criteria in developmental process, as on this point the activity of aerobic cytochrome c oxidase and cyclophorase begin to increase respectively.
parasitology-helminth-nematoda ; lactic dehydrogenase ; cytochrome c oxidaes ; cyclophorase ; Ascaris lumbricoides ; biochemistry

Congenital dislocation of the hip has always presented an unique problem in Orthopedic Surgery. Orthopedic surgeons have been baffled not only by the mystery of its origin, but also by its unpredictable course and the uncertainty of results of treatment. Hippocrates described this condition first with all its distinguishing characteristics, including distortion of the hip, the pathologic gait, the exaggerated lordosis. etc, His prognosis in this luxation of early childhood appeared to be unfavorable. In 1895, Lorenz established a new, decidedly conservative method of treatment. His process involved a complete separation of the two objectives to be fulfilled, namely reduction and retention. To retain this reduction he conceived the motion of fixing the hip for a specific and prolonged period in carefully chosen “primary position” of 90 flexion and 90 abduction by forcibly maintaining the head in its normal location. Ortolani, in 1935, was the first to show that a diagnosis could be establisted immediately after birth. The jerk, click or snap elicited by manipulation of the new born infants hip. Early diagnosis is still the most important aspect of congenital disiocation of the hip. Despite the emphasis on early diagnosis, a disturbingly large number of congenital dislocation of the hip remain undiagnosed until after the child has started to walk. Numerous surgical procedures and modifications have been used. The general types are: 1) Open reduction, 2) Shelf procedure, 3) Innominate osteotomy, 4) Arthroplasty, and 5) femoral osteotomy. These procedures have been useful also with the more difficult problem of residual or recurrent dislocation or subluxation aftertreatment by closed or open method. Congenital dislocation of the hip was not common in Korea like as in western countries. The reasons for this are poorly understood. But racial differences and native customs may offer a partial explanation. The author studied congenital dislocation of the hips in sex incidence, site of predilection, clinical symptoms and signs, X-ray findings, relation to the congenital anomalies and birth history, and the results of treatment. In this study, 57 cases of congenital dislocation of the hip, admitted to the orthopedic department of Severance Hospital during 7 years and 6 months since January 1963 until June 1970, were reviewed. The results of this study are as follows: 1. The annual changes of the numbers of the patients, who were first seen at Severance Hospital, were increasing. 2. The female incidence in Korea is relatively low as compared with the western countries. And the preponderance of females over males is in the ratio of ten to one in bilateral cases and two to one in unilateral cases. 3. The ratio of bilateral cases: right sides: left sides is 1:2: 2.2. 4. In these series, 15 cases of congenital anomalies or diseases in 13 patients are combined and among them, 10 patients are included in teratologic groups. And most common co-existing anomalies are club foot (7 cases). The incidence of the teratologic dislocation in Korea is relatively high as compared with the western countries. 5. The acetabualr index in affected hips showed no relationship to the age factor, but C-E angle, Y-coordinate and height are aggravated according to the increment of age. 6. Closed reduction is satisfactory under the age of 3, but after then the prognosis is poor. 7. Open reduction is recommendable after the age of 3 and under the age of 9. 8. The prognosis of treatment in bilateral cases and teratologic groups is poor.
Age Factors ; Animals ; Arthroplasty ; Child ; Diagnosis ; Dislocations ; Early Diagnosis ; Female ; Foot ; Gait ; Head ; Hip ; Humans ; Incidence ; Infant ; Korea ; Lordosis ; Male ; Methods ; Orthopedics ; Osteotomy ; Parturition ; Prognosis ; Reproductive History ; Surgeons ; Uncertainty

We analysed 26 cases of pyogenic osteomyelitis of the spine who were treaed at Younsei University Hospital during 25 years from January 1952 to August 1977 by operative or conaervative treatment. The diagnosis of pyogenic osteomyelitis of the spine is not easy and very confused. The cause and entry of the offending organism is mainly by venous drainage from the genitourinary and lower extremity circulation and the next is direct spreading from the adjacent focus. The typical clinical symptom is severe pain and tenderness over the lesion accompanied by febril history and the clinical course is relatively rapid than tuberculosis of the spine. In blood examination leukocytosis is uncommon but it showed relative increase of neutrophils in 62%, and erythrocyte sedimentation rate in 89%. Radiological findings are narrowing of joint space, erosion and/or destuctive change of vertebral body, vertebral marginal sclerotic change, and new bone formation and less frequently abscess shadow. The results obtained from this study were as follows, 1) The incidence of pyogenic osteomyelitis of the spine among total cases of the pyogenic osteomyelitis was 2.5% and the ratio of the pyogenic osteomyelitis of the spine to the spine tuberculosis was 2.8%. 2) The sexual incidence was in 11 and 15 each male and female. and the avrage, prevalent age was 34 years of age. 3) The pathogenic organism was isolated in 20 cases from the diseased focus during surgical procedure; stapyhloccus in 16 cases, pseudomonas in two and in a case of E.coli and proteus each. 4) The lumber vertebrae was mostly involved, i.e.lumbar in 11 cases, cervical in four, thoracic in nine, lumbosacral and sacrum in one each. 5) The operative treatment was performed in 23 cases and conservative in 3 cases with the satisfatory result in all cases. 6) We conclude that the focal curettage with anterior interbody fusion through anterior approach was better than the conservative treatment.
Abscess ; Blood Sedimentation ; Curettage ; Diagnosis ; Drainage ; Female ; Humans ; Incidence ; Joints ; Leukocytosis ; Lower Extremity ; Male ; Neutrophils ; Osteogenesis ; Osteomyelitis ; Proteus ; Pseudomonas ; Sacrum ; Spine ; Tuberculosis

Menkes disease is an X-linked recessively inherited neurodegenerative disorder of copper metabolism leading to death in early childhood. This disease is characterized by low serum, liver and brain Cu levels, whereas the Cu content in nearly all other organs is increased. The main clinical features are irregular kinky hair, characteristic face, progresssive degeneration of the central nervous system, bone changes, arterial rupture and thrombosis, and instability of temperature. We have experienced a case of Menkes disease in a eight months old male patient, who manifested by seizure, developmental delay, hypotonia, characteristic hair and face along with low levels of serum copper and ceruloplasmin. We report the characteristic findings of cranial MRI and MR angiography in this Menke's patient. In cranial MRI, he showed progressive brain atrophy with subdural hemorrhage and effusion. MR angiography revealed tortuosity of vessels clearly obviating necessity of more invasive conventional arteriography in diagnosis of this disease. This study suggested that cranial MRI and especially MR angiography might be helpful in making early diagnosis of this disease.
Angiography ; Atrophy ; Brain ; Central Nervous System ; Ceruloplasmin ; Copper ; Diagnosis ; Early Diagnosis ; Hair ; Hematoma, Subdural ; Humans ; Liver ; Magnetic Resonance Imaging ; Male ; Menkes Kinky Hair Syndrome ; Metabolism ; Muscle Hypotonia ; Neurodegenerative Diseases ; Rupture ; Seizures ; Thrombosis

Buschke-Lowenstein tumor is a rare disease in the category of designated as verrucous carcinoma characterized by its invasive downward penetration of underlying tissues in the perineum and perianal regions. Viruses, unclean sanitation and cytotoxic immune reaction have been proposed as the etiology of the tumor. However, among all the causes, recent studies have emphasized on the associaton of the tumor and human papilloma virus (HPV). Expecially, HPV also has been discovered in several cutaneous and anogenital lesions of solid organ transplant recipients. We herein report a case of Buschke-Lowenstein tumor in a renal transplant recipient with HPV 6 and 16 coinfection proved by HPV genotyping of DNA extracted from the biopsy specimen of the tumor.
Biopsy ; Buschke-Lowenstein Tumor* ; Carcinoma, Verrucous ; Coinfection ; DNA ; Human papillomavirus 6 ; Humans ; Papilloma ; Perineum ; Rare Diseases ; Sanitation ; Transplantation* ; Transplants

BACKGROUND: The purpose of the study was to compare and contrast ankle range of motion, functional ability, talar- tilt angle and foot injuries between high school ballet majors with and without foot deformities and to provide fundamental data about effective intervention methods for their successful performance and injury prevention. METHODS: Subjects were 18 female high school ballet dancers, eight with foot deformities and ten without foot deformities. For statistical analysis, the independent t-test (SPSS 20.0; SPSS Inc, Chicago, IL, USA) was used and the significant level of P<0.050 was selected. RESULTS: 1. Foot injuries of plantar flexion and talar tilt were significantly different between the two groups (P<0.050). 2. The deformity group displayed a higher proportion of mechanical instability compared to that of the control group. CONCLUSIONS: Foot deformities in high school students majoring in ballet can have negative effects to the ankle joint, with a strong possibility of ankle instability and foot injuries linked to tarlar tilt, and quite probably, of chronic ankle sprain.
Ankle Injuries ; Ankle Joint ; Ankle* ; Congenital Abnormalities ; Female ; Foot Deformities* ; Foot Injuries* ; Humans ; Range of Motion, Articular*

BACKGROUND: The purpose of the study was to compare and contrast ankle range of motion, functional ability, talar- tilt angle and foot injuries between high school ballet majors with and without foot deformities and to provide fundamental data about effective intervention methods for their successful performance and injury prevention. METHODS: Subjects were 18 female high school ballet dancers, eight with foot deformities and ten without foot deformities. For statistical analysis, the independent t-test (SPSS 20.0; SPSS Inc, Chicago, IL, USA) was used and the significant level of P<0.050 was selected. RESULTS: 1. Foot injuries of plantar flexion and talar tilt were significantly different between the two groups (P<0.050). 2. The deformity group displayed a higher proportion of mechanical instability compared to that of the control group. CONCLUSIONS: Foot deformities in high school students majoring in ballet can have negative effects to the ankle joint, with a strong possibility of ankle instability and foot injuries linked to tarlar tilt, and quite probably, of chronic ankle sprain.
Ankle Injuries ; Ankle Joint ; Ankle* ; Congenital Abnormalities ; Female ; Foot Deformities* ; Foot Injuries* ; Humans ; Range of Motion, Articular*

BACKGROUND: The purpose of the study was to compare and contrast ankle range of motion, functional ability, talar- tilt angle and foot injuries between high school ballet majors with and without foot deformities and to provide fundamental data about effective intervention methods for their successful performance and injury prevention. METHODS: Subjects were 18 female high school ballet dancers, eight with foot deformities and ten without foot deformities. For statistical analysis, the independent t-test (SPSS 20.0; SPSS Inc, Chicago, IL, USA) was used and the significant level of P<0.050 was selected. RESULTS: 1. Foot injuries of plantar flexion and talar tilt were significantly different between the two groups (P<0.050). 2. The deformity group displayed a higher proportion of mechanical instability compared to that of the control group. CONCLUSIONS: Foot deformities in high school students majoring in ballet can have negative effects to the ankle joint, with a strong possibility of ankle instability and foot injuries linked to tarlar tilt, and quite probably, of chronic ankle sprain.
Ankle Injuries ; Ankle Joint ; Ankle ; Congenital Abnormalities ; Female ; Foot Deformities ; Foot Injuries ; Humans ; Range of Motion, Articular

Since the placenta is an organ composed of blood vessels, it is not surprising that its primary neoplasm would be a vascular tumor. Placental tumors, primary or secondary, have been known to interfere with placental function. Chorioangioma(primary tumor of the placenta), which is the most common of them, occurs with an incidence for clinically significant ranges from 1~2.8:10000 births. These tumors are benign and are not usually associated with clinical sequelae unless they are larger than 5cm in long diameter. About one third of the large chorioangiomas may be associated with the maternal and fetal complications. For diagnosis of these lesions, the ultrasonography was used. If the chorioangioma is suspected, color doppler study is informative to confirm the presence of the vascular channels. We reviewed ultrasonograms and clinical records of seven patients who had been diagnosed as placental chrioangioma. The appropriate diagnostic tests and treatment can then be initiated in order to prolong gestation and decrease fetal mortality and morbidity.
Blood Vessels ; Diagnosis ; Diagnostic Tests, Routine ; Fetal Mortality ; Hemangioma* ; Humans ; Incidence ; Parturition ; Placenta* ; Pregnancy ; Prenatal Diagnosis* ; Ultrasonography

No abstract available.
Dermatitis, Atopic* ; Histamine* ; Humans ; Interleukin-12*