In the diagnosis of parasitic helminthic diseases, the value of examining and identifying the parasitic eggs and/or adult parasites from patient's urine or stool are well appreciated. However, these methods have a limited value in the diagnosis of tissue or intracellular parasitism, and we have to rely on supplementary methods such as immuno-serological test. The author tested the value of gel precipitation reactions as a diagnostic method of clonorchiasis by observing the appearance of bads on rats experimentally infected with Clonorchis sinensis. And the therapeutic effect of CIBA 35'058-Ba was evaluated by this serological method. The antigen was prepared from the adult worms infected in rabbits by Tsuji method. Rats infected with 40 metacercariae each were bled on 7, 14, 21, 26, 28, 39, 42(43), 49(53) days after infection to observe the appearance of precipitin bands by both Pucterlony method and immunoelectrophoresis. Fifteen rats were separately infected and treated with CIBA 35'058-Ba in dose of 15mg/kg of body weight. The following results were obtained : 1. It was observed that there exist individual variations in the appearance of the first precipitin band with the range of 2-4 weeks after infection. 2. The number of precipitin bands was increased until 6-7 weeks after infection. In all cases, 3 precipitin bands were appeared by Oucterlony method and 6-7 bands were appeared by immunoelectrophoresis after 6-7 weeks of infection. 3. It was hardly possible to notice any change in the number of bands after the administration of CIBA 35'058-Ba. This result suggested that the drug has no effect on clonorchiasis which was confirmed by the autopsy of the experimental rats.
Adult ; Animals ; Autopsy ; Body Weight ; Clonorchiasis ; Clonorchis sinensis* ; Diagnosis ; Eggs ; Helminths ; Humans ; Immunoelectrophoresis ; Metacercariae ; Ovum ; Parasites ; Rabbits ; Rats*

No abstract available.
Halitosis*

No abstract available.
Halitosis*

A case of verrucous hemangiorna appearing 22-year old male as presented, The clinical lesion was wart-like and hyperkeratotic scaly plaque with satellite lesions occurring over the right side of the skin. Histopathological examination showed hyperkeratosis, papillomatosis, irregular acanthosis, and capillary hemangiomatous features in the dermis and subecutantous tissues.
Capillaries ; Dermis ; Hemangioma* ; Humans ; Male ; Papilloma ; Skin ; Young Adult

Two cases of toxic epidermal necrolysis (Lyell) appearing on 69-year old male and 12year-old female were presented. The clinical manifestations of toxic epidermal necrolysis developed after oral administration of novaquing for common cold. The cause of the disease was probably due to novaquing (phenobarbital and sulpyrin). The 69 year-old male was expired despite intensive treatment with fluid and electrolytes, antibiotics, corticosteroids, vitamins, and topical measures, but 12 year-old female was cured successfully with treatment.
Administration, Oral ; Adrenal Cortex Hormones ; Aged ; Anti-Bacterial Agents ; Child ; Common Cold ; Electrolytes ; Female ; Humans ; Male ; Stevens-Johnson Syndrome* ; Vitamins

Since Duhamel (1739), numerous experimental studies on the longitudinal growth of growing long bone have been reported. In Hales(1747) experience, growing long bone showed overgrowth after drilling in the tibia of chickens. David(1924) observed the fact that various degrees of shortening disappeared within 15 months after fracture of the femur in children and he concluded that fractures in children should be treated with the caution that the growing long bone has a tendency to increase in length after injury. Bisgard(1936) concluded that shortening from overriding of fragments in fractured extremities of children will frequently, but not invariablly, become partially or totally eliminated by the acceleration of growth which incidentaIly results from the inflammatory process, incited by trauma and fracture repair. Hass(1926) reported that interstitial proliferation of osseous tissue plays no part in the elongation of a growing bone, either in the mature bone or the young osteoid tissue bordering on the epiphyseal cartilage plate, and length growth of bone is entirely dependant on the purposeful multiplication of cartilage cells of the epiphyseal cartilage plate. Ham(1952) reported that the growth of long bone depends upon the interstitial growth of cartilage. This study was initiated to investigate the effects of fractures in the longitudinal bone growth of growing bone. Artificial fractures were made at two different sites in the diaphysis of the tibia in young rabbits. The operation for artificial fracture was performed under general anesthesia with ether. The type of fracture was an incomplete one, leaving a part of the posterior cortex of the tibia, in order to prevent the displacement of fractured fragments. In all of the cases, no cast immobilization was applied. After the fractures, follow up observations were made weekly till the 4th week, and thereafter at two week intervals, with roentgenographic, lethal measurement and histological examination. The results were as follows; 1) Longitudinal bone growth was increased from fracture of the diaphysis of growing long bone. 2) Compared with the control limb, tendency to overgrowth of growing bone was noted from the first week after the operation. 3) In follow up measurements, no growth inhibition was observed till the 10th week after the operation, but, thereafter, a tendency to reduce the proliferation of cartilage cells was noted. 4) In cases of fracture of the mid 1/3, the gorwing activity in the epiphyseal plate was increased more than from proximal 1/3 fractures. 5) The bony growth, accelerated by fractures in diaphysis of growing long bone without displacement was transient, and the prolonged overgrowth was compensated by the reduction of growing activity and premature closure of the epiphysis.
Acceleration ; Anesthesia, General ; Bone Development ; Cartilage ; Chickens ; Child ; Diaphyses ; Epiphyses ; Ether ; Extremities ; Femur ; Follow-Up Studies ; Growth Plate ; Humans ; Immobilization ; Rabbits ; Tibia

PURPOSE: Prader-Willi Syndrome(PWS) is caused by absence of paternal contributions of the chromosome region 15q11-q13. To detact this region, high resolutional cytogenetic analysis, FISH with probe at PWS critical region or microsatellite polymorphism can be used. The gene for the small nuclear ribonucleoprotein polypeptide N(SNRPN) is not expressed in patients with PWS. We conducted molecular analysis with RT-PCR with SNRPN primers to find out more useful diagnostic tool in PWS. METHODS: Four patients with obesity and other characteristics of PWS were studied. The exprssion of SNRPN and control gene were studed by RT-PCR from peripheral lymphocytes. RESULTS :The SNRPN expression in reverse transcribed RNA from blood were easily detected in normal control but not in patients with suspected Parder-Willi Syndrome. CONCLUSION: We conclude that SNRPN expression study is a useful diagnostic method for detection of Prader-Willi Syndrome.
Cytogenetic Analysis ; Humans ; Lymphocytes ; Microsatellite Repeats ; Obesity ; Pathology, Molecular* ; Prader-Willi Syndrome* ; Ribonucleoproteins, Small Nuclear ; RNA ; snRNP Core Proteins*

No abstract available.

In order to find out health problems among inhabitants in slum areas in Kwanak-Ku, Seoul, a series of health survey was conducted upon 510 households by interview from March to December, 1976. The results obtained were as follows: 1. Employments of householders were unstable; Out of 508 householders, 164(32.3%) were unemployed and 184(36.2%) were daily or temporary employees. 2. Average number of households per house was 2.0 and average area of residential room per person was 4.0m2. 3. 476(93.3%) out of 510 households were supplied with tap water and rest of them made use of ground water as a source of drinking water. 4. Only 279(18.3%) out of 1527 live births were delivered at medical facilities, 496(32.7%) were at home attended by doctors or midwives and 358(25.1%) took prenatal care. The above findings were worse in urban slum area than in other urban area of relatively high economic level, but were better than in rural area of less medical facilities. 5. Initiation of treatment were delayed until their illnesses were advanced in most of the households, 472(92.5%) out 510. In the early stage of the illness, 131(25.6%) of the households sought physicians in their clinics or general hospitals and 250(40.9%) visited chemists, to buy drugs at first hand. Frequency of visits to physician increased to 52.8% as the disease aggravated in later stages. 6. Cost of medical expenditure per household amounted to 815 won, and was paid to, in the order of chemists, physicians, chinese herb stores, chinese herb doctors. 7. Concerning the health knowledge of the inhabitants, 273(53.9%) out of 506 respondents were aware of the infectivity of pulmonary tuberculosis, and 68(13.4%) of them checked regularly their chest findings by X-ray at least once every two years. 8. As for the family planning, although 448(87.3%) out of 510 respondents were in favor of it, 213(41.8%) of them were actually practicing contraception. 9. About 40.6% (125 respondents) of them obtained information and knowledge concerning contraception through personal contact with family planning workers. 10. Nutritional status of housewives was generally poor: 49(38.3%) out of 128 housewives were found to be anemic and average serum protein level was 7.5+/-0.82 g/dl.
Asian Continental Ancestry Group ; Contraception ; Surveys and Questionnaires ; Drinking Water ; Family Characteristics ; Family Planning Services ; Groundwater ; Hand ; Health Expenditures ; Health Surveys ; Hospitals, General ; Humans ; Live Birth ; Midwifery ; Nutritional Status ; Poverty Areas* ; Prenatal Care ; Seoul ; Thorax ; Tuberculosis, Pulmonary ; Water

No abstract available.
Child* ; Evoked Potentials, Auditory, Brain Stem* ; Humans ; Nervous System Diseases*