Objective To compare the therapeutic effect of azithromycin and erythromycin in the treatment of children with Mycoplasma pneumoniae infection complicated with central nervous system involvement.Methods Mycoplasma pneumoniae infection in children with central nervous system damage treated in our hospital from March 2014 to June 2015 were selected as the observation object.According to the treatment method,it was divided into treatment group(45 cases)and control group(50 cases),the control group was given erythromycin tablets,the treatment group given azithromycin.To observe the therapeutic effect of two groups,compared the cerebrospinal fluid inflammatory cytokine levels and lung function of the two groups before and after treatment.Results The effective rate of treatment group was significantly higher than that of control group,and the difference was statistically significant(P<0.05); After treatment,the indexes of lung function in patients of the two groups were increased before treatment,and the treatment group increased more significantly(P<0.05); The level of hs-CRP,IL-6 and other inflammatory cytokine of the two groups of patients before treatment had no significantly difference,after treatment,the two groups of patients with the above indicators were lower than before treatment,and the treatment group decreased more significantly(P<0.05).Conclusion Azithromycin and erythromycin in children with Mycoplasma pneumoniae infection complicated with central nervous system involvement have better treatment effect,and the effect of azithromycin is better,has a high clinical value.

Objective To analyze the correlation between blood lead,zinc levels and tic disorders(TD) in children.Methods One hundred and fourteen children with TD were chosen as observation group,and 100 healthy children were chosen as control group.The serum levels of lead and zinc were compared between the two groups,and the correlation between blood lead,zinc levels and TD was analyzed.Results The serum level of blood lead in the observation group was (70.8 ± 14.9) μg/L,which was higher than (50.9 ± 13.8),μg/L in the control group,the difference was statistically significant(t =4.932,P ＜ 0.05).The serum level of blood zinc in the observation group was (461.4 ±33.2)μg/L,which was lower than (501.5 ± 34.1)μg/L in the control group,the difference was statistically significant(t =5.217,P ＜ 0.05).The serum level of blood lead ≥60μg/L and the serum level of blood zinc ＜470μ g/L were significantly related with TD(OR =2.192,2.012,all P ＜ 0.05).Conclusion The blood lead and zinc levels are significantly correlated with TD in children.