Objective To study the relative risk factors of simultaneous gastric and colonic polyps,pro-vide theoretical basis for simultaneous gastrointestinal endoscopy monitoring for high-risk population. Methods Retrospective analysis on the patients with a total of 506 cases in the department of gastroenterology of Zhujiang Hospital from 2014 to 2016 and diagnosis gastric polyps or colonic polyps. Adopt cases-control research,the pa-tients(138)with gastric polyps and colonic polyps were divided into case group,the patients(99)with gastric polyps or colonic polyps(269)were divided into control group.Results The colonic polyps group is mainly com-posed of male(69.1%);while gastric polyps group is mainly composed of female(76.8%);The proportion of the patients over 50 years old with gastrointestinal polyp is higher(81.9%).The proportion of Hp infection in the colon-ic polyps group is higher(43.1%),followed by the cases group(31.9%).The composition of the pathological types between gastric polyps group,colonic polyps group and cases group is similar,while there is no correlation on the pathological types between gastric polyps and colonic polyps in the cases group. Conclusion The male patients who diagnosis gastric polyps should perform colonoscopy,the gastric polyps patients who is Hp infection should per-form colonoscopy,the patients over 50 years old are suggested to perform gastrointestinal endoscopy. There is no correlation on the pathological types between gastric polyps and colonic polyps,further studies will be conducted to expand the study sample size.

OBJECTIVE： To screen and characterize effective components of immunopotentiating activity in Senecionis cannabifolii Herba. METHODS： The polysaccharide components were obtained by water extraction and alcohol precipitation method to yield 50％ alcohol precipitation sample （SCHE-1） and 80％ alcohol precipitation sample （SCHE-2）. The cells from mice mononuclear macrophage line RAW264.7 were divided into blank group （medium without serum）， negative control group （medium with serum）， lipopolysaccharide group （LPS， positive control drug， 1 μg/mL）， SCHE-1 and SCHE-2 low-dose and high-dose groups （0.5， 1 mg/mL）. The cell viability of RAW264.7 cells was detected by MTT assay. The levels of IL-1β， IL-6 and TNF-α in RAW264.7 were detected by ELISA. These were used to investigate the effects of SCHE-1 and SCHE-2 on the immunological enhancing activity of RAW264.7 cells. The molecular weight and distribution of SCHE-1 were determined by size exclusion chromatography； the monosaccharide composition of SCHE-1 was determined by HPLC pre-column derivatization. Methylation analysis of SCHE-1 was conducted by NaOH method. RESULTS： Compared with negative control group， the activity of RAW264.7 cells was enhanced significantly in SCHE-1 groups and LPS group， which also significantly increased the levels of IL-1β， IL-6 and TNF-α in cell culture fluids （P＜0.01）. SCHE-1 was an effective component with immunopotentiating activity. The neutral sugar content of SCHE-1 was 40.05％， the uronic acid was 35.62％， and the protein was 8.89％. SCHE-1 was a mixture， molecular weight of which was 62-6 119 Da； monosaccharide was mainly composed of galacturonic acid， arabinose （Ara） and galactose （Gal）. The results of methylation analysis showed that the backbone was composed of 1→3， 1→4 and 1→6 linked Gal， and branches were on the O-6 position of the 1→3 linked Gal， and the non-reducing terminals were Ara. CONCLUSIONS： SCHE-1 may be the effective component of immuno potentiating activity， and main component of SCHE-1 is polysaccharide. SCHE-1 may regulate the immune function by activating macrophages to release IL-1β， IL-6 and TNF-α.