By analyzing the scope and demands of mental health service in general hospitals, the authors point out that at present domestic general hospitals are confronted with such problems as insufficiency of resources for mental health service, low recognition rate of dysphrenia, and lack of systematic consultations and liaison in psychiatric work. Then they put forward a number of measures for improving mental health service in general hospitals: ①establishing a department of psychiatry in each general hospital; ②widely conducting consultations so as to maintain a strong liaisom in psychiatric work; ③genuinely achieving the transformation of the medical mode; ④strengthening education in psychological medicine and the spread of popular science so as to broaden the channel and coverage of mental health service and meet the needs of reform and development of the health cause in the contemporary era.

Objective To study the protective effects of th e polypeptides isolated from Chlamys farreri(PCF)against ultraviolet B radiatins.Methods An oxidative damage model of HeLa epi thelial cell line irradiated by ultraviolet B(UVB 7.15?10 -5 J /cm 2 )was established.The HeLa cells were randomly divided into six groups:control group,UVB radiated groups(radiated control,0.5%PCF,1%PCF,2%PCF,1%Vit C).The enzymic activities of HeLa cells were tested by MTT methods,the apoptosis rate an d death rate of HeLa epithelial cells and the content of free calcium in those cells were tested by using flow cytometry(FCM).The contents of MDA and the activities of GSH-Px ,SOD,CAT in the supernatants of cells were determin ed by biochemical methods.Results The results indicated that polypept ides fromChlamys farreri could enhance the activities of GSH-Px,SOD,CA T and decrease the contents of MDAin the su pernatants of HeLa cells,increase t he concentration of cellular free calciumin the cells,and decrease the rates of apoptosis and cell death of the cells .Conclusions The PCF has the protective effects on the HeLa cells irradiated by ultraviolet B.The mechanism of th is effects of PCF may be mediated by e-liminating the free radicals,by increasing the activities of antioxidative enzymes to inhibit the oxidativ e damages caused by UVB .

Objective To study the effects of polypeptide from Chlamys farreri(PCF) on PI3K/Akt and ASK1-JNK signal transduction pathway in thymocytes after ultraviolet B radiation.Methods Murine thymocytes were exposed to UVB radiation.The reactive oxygen species(ROS) level in thymocytes was detected by colormatching.The activation of Akt was investigated by western-blot.ASK1,JNK activation,mitochondria memberine potential and DNA ladder were also investigated after pretreatment with or without PI3K/Akt pathway inhibitor LY294002.Results PCF could activate Akt,inhibit the activation of the ASK1 apoptosis pathway in murine thymocyte radiated by UVB.Conclusion PCF decreased ROS level,increased Akt activity and inducing ASK1 degradation leading to the inhibition of ASK1-JNK induced apoptosis.

With the aging of the global population,frailty is now considered a unique old age syndrome,has become an important worldwide public health problems.The elderly people is at increased risk of falls,hip fractures,disability,death and other risks.Motor system disease as an independent risk factor participates in frailty progress and interacts with each other.This article reviews recent studies on frailty and motor system diseases.

Objective To analyze the distribution characteristics of Pseudomonas aeruginosa and Acinetobacter baumannii ,and to investigate the changing pattern of antimicrobial resistance of these strains isolated during 2012 - 2014 .Methods Strains of Pseud‐omonas aeruginosa and Acinetobacter baumannii isolated from January 2012 to December 2014 were collected .Antimicrobial suscep‐tibility of clinical isolates was tested by Kirby‐Bauer method .Results In the past three years ,214 strains of Pseudomonas aerugino‐sa and 347 strains of Acinetobacter baumannii were isolated .The nosocomial infection rate of Pseudomonas aeruginosa decreased year by year ,while the Acinetobacter baumannii ′s increased .Most strains were isolated from sputum ,wound secretion and urine . The strains of Pseudomonas aeruginosa and Acinetobacter baumannii were distributed in various departments of the hospital .The detection rates of these strains were the highest in ICU ,respectively 27 .6% and 34 .9% .Both the resistance rates of Pseudomonas aeruginosa to ceftazidime ,imipenem ,Amikacin and Acinetobacter baumannii to Piperacillin/Tazobactam and imipenem had in‐creased ,while the resistance rates of Acinetobacter baumannii to polymyxin B had decreased with each passing year .Conclusion Pseudomonas aeruginosa and Acinetobacter baumannii causes severe nosocomial infections and the antimicrobial resistance rates in‐creased ,especially the resistance rates to carbapenem are becoming more higher in recent years .Acinetobacter baumannii shows strong antibacterial activity in vitro to Polymyxin B .Therefore ,antimicrobial resistance surveillance should be strengthened to direct rational use of antibiotics .

Objective To analyze the literature distribution and research status of osteoporosis in the elderly published in Chinese Medical Association journals.Methods The literatures of elderly osteoporosis published in Chinese Medical Association journals from 2008 to 2013 were collected.And the publication year,distribution,content,institution and region of the literatures were analyzed.Results From 2008 to 2013,there were 76 articles about osteoporosis in the elderly published in 22 kinds of journals of the Chinese Medical Association.Among these journals,the Chinese Journal of Geriatrics-published elderly osteoporosis articles occupied the most number [28 (36.8％)].There were 21 articles published mostly in 2013 (27.6％),secondly in 2009 (17 articles,22.4％) and 2012 (12 articles,15.8％).The province or city that published more than 10 articles was Beijing (18 articles,23.7％),Zhejiang (13 articles,17.1％),Shanghai (10 articles,13.2％) and Guangdong (10 articles,13.2％).The institution that published most articles was Beijing Jishuitan Hospital (4articles,5.3％).The main contents of these literatures included the influencing factors,diagnosis,treatment strategy,bone metabolism and surgery treatment for elderly osteoporosis.Conclusions Chinese Medical Association journals are the important source to acquire osteoporosis literature for the medical workers.The distribution of journal is relatively concentrated,but the distribution of authors,institution is dispersed.Chinese Journal of Geriatrics publishes the most number of articles.The research of osteoporosis has attracted more attention.

Objective To analyze the citation of papers published in Chinese Journal of Geriatrics from the year 2008 to 2012,and evaluate the quality and academic level of the journal.Methods Based on the information from Wanfang database,bibliometric analysis was conducted to analyze number of cited papers,citation frequency,citation time distribution,authors,funds supports etc,and immediacy index and citation half-life were calculated.Results A total of 1567 papers were published in the journal from the year 2008 to 2012,and 377 articles were cited for 669 times with citation rate of 24.06％.The average number of cited times was 1.77,and the top value per article cited was 18 times.There were 12 authors whose articles were cited 6 and over times,and 11 affiliations whose articles were cited more than 10 times.Among 377 papers,105 papers (27.85％) were supported by funds,among which the majority was provincial fund (36 papers) and national fund (35 papers).Immediacy index from the year 2008 to 2012 were 0.042,0.032,0.019,0.067 and 0.006,respectively,and the citation half-life was 1.71 in the year 2012.Conclusions Articles published in Chinese Journal of Geriatrics have high-quality and can reflect the development and research progress in geriatric medicine.The journal is one of the most important information resources in geriatric academic field in China.

Objective To study the literatures distribution and research status of the elderly tuberculosis published in the Chinese Medical Association Journals (CMAJ) from 2004-2013 in order to provide literature methodological data for the tuberculosis research.Methods The literatures on the elderly tuberculosis published in 82 kinds of CMAJs from 2004-2013 were classified and analyzed.The publication year,distribution,content,author,institution and region of these literatures were analyzed.Results There were 66 articles about the elderly tuberculosis published in 20 kinds of the Chinese Medical Association Journals.These literatures were published mostly in 2011 (16 articles,24.2％),secondly in 2012 (13 articles,19.6％) and 2010 (7 articles,10.6％),which were published mostly in Chinese Journal of Geriatrics (15 articles,22.7％).The main contents included clinical diagnosis and treatment,epidemiological investigation and drug research.The most published form was treatise (55 articles,83.3 ％).Most of the articles involved in pulmonary tuberculosis (34 articles,51.6 ％).The provinces or cities in which the most articles were published were Beijing (28 articles,42.4％) and Shandong (6 articles,9.1％).There was significantly difference in the article number between 2004-2008 and 2009-2013 (P＜ 0.05).The epidemiology,drug resistance mechanism,influencing factors,clinical characteristics,diagnosis and treatment strategy of the elderly tuberculosis,especially diagnosis and treatment development were well discussed in these literatures.Conclusions The literatures of the elderly tuberculosis published in Chinese Medical Association Journals are insufficient in quantity,with number increases of articles significantly over the past 5 years.Projects supported by the foundation is less and discipline construction should be strengthened.The distributions of authors and the primary population of tuberculosis are different,and early diagnosis and treatment of pulmonary tuberculosis in the elderly are concerned especially.

Objective To analyze the citation characteristics of literatures in Chinese Journal of Geriatrics published from 2008 to 2012.Methods According to the information from Wanfang database,articles in Chinese Journal of Geriatrics published from 2008 to 2012 were surveyed.The quantity,type of languages and the self-cited rate,etc were analyzed,and the Price's index,half life of literatures were calculated.Results Of the 1567 papers published in the journal from 2008 to 2012,1479 papers cited 16054 literatures,with a citation rate of 94.4％.The average number of citations in each paper was 10.25.The major language of citation was English (73.33％),followed by Chinese (26.67％),and only one citation was in Japanese.The self cited rates of author and periodical were 1.20％ and 5.23％,respectively.The Price's index was 45.71％ and the half-life of literatures was 4.27 years.Conclusions The authors of Chinese Journal of Geriatrics cite a wide range of literature,and the journal plays an important role in publicizing research achievements of geriatric medicine.However,the average number of citations in each paper,timeliness and novelty of cited literatures,diversity of citation languages need further improving.

Objective To understand the research status and development tendency of domestic geriatrics.Methods To analyze all the key words in the academic articles from five representative Chinese journals of geriatrics from 2009 to 2013 through key words frequency analysis.Results From 2009 to 2013,the 55212 key words in 15314 articles were analyzed.The percentages of the articles indexing 3,4 and 5 keywords were 39.3％ (6012/15314),33.3％ (5092/15314) and 13.9％(2123/15314),respectively.There were 45 high-frequency keywords,among which 17 key words (37.8％) were in the top 30 every year.The main research object of geriatrics was Aged,the main research contents were common diseases in the elderly,including Diabetes Mellitus,Coronary Artery Disease,Alzheimer's Disease,Hypertension,Cerebral Infarction,Cognition Disorders and etc.The Risk Factors,Therapeutics and Prognosis of these common diseases were always explored.Co-words analysis showed that there were 51 pairs of key words with a frequency more than or equal to 20.Conclusions The hot-spot of geriatric research in our country is relatively concentrated.We should pay attention to body disease,and focus on the mental health problems in the elderly.