Studies on the relationship between Helicobacter pylori infection and colorectal cancer have been controversial in recent years. The Chinese "eat-together system" dietary culture and the life style of family gathering result in a high infection rate of Helicobacter pylori, and the relationship between Helicobacter pylori and tumors has thereupon become one of the research hotspots. Studies have shown that Helicobacter pylori infection may promote the occurrence of colorectal precancerous lesions and colorectal cancer by inducing hypergastrinemia, destroying intestinal microecology, suppressing immune function and other ways. This article reviews the research progress on the relationship between Helicobacter pylori infection and colorectal cancer and its mechanism.

Colorectal cancer (CRC) is one of the most common digestive system tumors and the second most common tumor in the world in terms of mortality. The current chemotherapeutic drugs applied in clinical treatment seriously affect the survival quality of patients due to adverse reaction and susceptibility to chemoresistance. Therefore, it is necessary to search for novel anti-CRC drugs. As natural compounds, polyphenols components of traditional Chinese medicine can exert anti-CRC properties through various mechanisms, such as promoting apoptosis, inhibiting cell proliferation, and inducing iron death. In addition, it can reverse the resistance of CRC cells to chemotherapeutic drugs. Further exploration of the anti-CRC action mechanism of polyphenols constituents of traditional Chinese medicine may provide a certain reference basis for clinical application.

The timing for closure of prophylactic ileostomy after rectal cancer surgery is not unified, and it is generally recommended to return the stoma after 3 months. With the application of enhanced recovery after surgery in clinical patients and the continuous progress of technology, the effectiveness and safety of early ileostomy closure (EIC) are the focus of current researches. More and more patients with rectal cancer begin to receive neoadjuvant chemoradiotherapy, which also brings uncertainty to the time of ileostomy closure. prophylactic ileostomy not only brings about stoma-related complications, but also brings great psychological burden to patients. Some patients have an urgent need for EIC, but there is no consensus on the optimal timing for EIC and which patients need EIC. This article reviews the advantages, controversies, optimal timing, the influence of chemoradiotherapy, the indications and contraindications of early closure and provide reference for clinicians.

Objective To explore the clinical value of laparoscopic ventral rectopexy for rectal prolapse.Methods From Jan 2013 to Jan 2017,26 patients with complete rectal prolapse were divided into control group (15 patients) undergoing laparoscopic rectal fixation,and 11 patients in study group were treated with rectal ventral fixation.Results There was no significant difference in operation time,bleeding volume and exhaust time between the two groups (t =1.839,0.138,0.932,all P ＞ 0.05).In the study group,2 cases had temporarily postoperative fever.Following up for 12 to 36 months,1 case recurred in the control group and 1 case in the study group.The length of rectal prolapse was about 2 cm.Of the 7 patients with constipation in the control group,symptoms disappeared in 2 cases,symptoms improved in another 2 cases,and 5 cases had new constipation.Of the 4 patients with anal incontinence,2 cases had recovered and 1 case had symptoms improved.Among the 6 patients with constipation in the study group,symptoms disappeared in 3 cases,symptoms improved in 2 cases.Of the 3 patients with pelvic prolapse,2 cases recovered and 1 case improved.The pelvic prolapse and constipation in the study group was less severe than that in the control group (x2 =4.909,P ＜ 0.05).Conclusion Laparoscopic rectal ventral fixation for the treatment of complete rectal prolapse is less traumatic,safor and more effective.