Innovative Experiment Competition of Preventive Medicine is a significant constitution of Guangdong Undergraduate Technique Competition of Preventive Medicine. Without the constriction of majors, students participate in group with 3 people, design their own experiments around the hot spots and practical problems in public health area and are awarded according to the grades of the experiment design and thesis defence. The most topics in the first and the second competitions are about environmental hygiene and occupational hygiene, and the infectious diseases are attracting increasing attention. More and more topics combine the method of experiment with investigation. Some tactics are also suggested that innovation, view of general population, autonomy and investigation should be included in topic selection for this contest.

Traumatic brain injury（TBI）in combination with its sequelae is currently a public health problem that seriously endangers human health. Accumulating studies have deeply investigated the pathological processes of TBI to find possible therapeutic targets. In recent years，the relationship between TBI pathogenesis and gut-brain axis changes in aspects of microflora，metabolites，inflammatory factors and neurohumoral changes has drawn widespread attention，which not only provides a better understanding how TBI affects gut-brain axis，but also provides new therapeutic targets in improving cure rate and recovery level after TBI. However，due to the existence of complicated gut-brain axis self-regulation as well as the individual differences of TBI patients，the recognition and transformation for the latest experimental research are largely limited. In this review，the authors summarize how TBI event influences gut-brain axis balance，as well as how gut-brain axis regulates TBI pathogenesis mutually，so as to provide a better understanding of the interaction between gut-brain axis and TBI.