1.Clear cell papillary cystadenoma of left mesosalpinx associated with von Hippel-Lindau disease: report of a case.
Xiang-lei HE ; Chun-nian WANG ; Jian-min ZHANG
Chinese Journal of Pathology 2009;38(5):349-350
Adenocarcinoma, Clear Cell
;
complications
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metabolism
;
pathology
;
surgery
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Adenoma
;
pathology
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Adnexal Diseases
;
pathology
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Adult
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Carcinoma, Renal Cell
;
pathology
;
secondary
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Cystadenoma, Papillary
;
complications
;
metabolism
;
pathology
;
surgery
;
Diagnosis, Differential
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Fallopian Tube Neoplasms
;
complications
;
metabolism
;
pathology
;
surgery
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Female
;
Follow-Up Studies
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Humans
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Keratin-7
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metabolism
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Kidney Neoplasms
;
pathology
;
secondary
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Mucin-1
;
metabolism
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von Hippel-Lindau Disease
;
complications
;
metabolism
;
pathology
;
surgery
2.Extraventricular neurocytoma of spinal cord: report of a case.
Chun-nian WANG ; Xiang-lei HE ; Zhao-xia XIA
Chinese Journal of Pathology 2012;41(10):702-703
Antigens, Nuclear
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metabolism
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Cordotomy
;
methods
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Diagnosis, Differential
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Ependymoma
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metabolism
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pathology
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Follow-Up Studies
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Humans
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Male
;
Middle Aged
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Nerve Tissue Proteins
;
metabolism
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Neurocytoma
;
metabolism
;
pathology
;
surgery
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Oligodendroglioma
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S100 Proteins
;
metabolism
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Spinal Cord Neoplasms
;
metabolism
;
pathology
;
surgery
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Synaptophysin
;
metabolism
3.Littoral cell angioma of the spleen in a patient with chronic hepatitis B and hepatocellular carcinoma.
Chun-Nian WANG ; Xiang-Lei HE ; Hong-Bin ZHANG ; Hua-Xin DING
Chinese Journal of Pathology 2007;36(12):858-859
Carcinoma, Hepatocellular
;
complications
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Hemangioma
;
complications
;
diagnosis
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immunology
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pathology
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Hepatitis B, Chronic
;
complications
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Hepatocytes
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cytology
;
pathology
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Humans
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Liver Cirrhosis
;
complications
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Liver Neoplasms
;
complications
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Male
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Middle Aged
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Platelet Endothelial Cell Adhesion Molecule-1
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immunology
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Spleen
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immunology
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pathology
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Tomography, X-Ray Computed
4.Expression and clinical significance of hypoxia inducible factor-1alpha, survivin and vascular endothelial growth factor in esophageal squamous cell carcinoma.
Hong-zhen ZHANG ; Jing ZHANG ; Ning XU ; Xin-bo DUAN ; Chun-nian HE
Chinese Journal of Pathology 2007;36(10):689-690
Adult
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Aged
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Aged, 80 and over
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Carcinoma, Squamous Cell
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metabolism
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pathology
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radiotherapy
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Esophageal Neoplasms
;
metabolism
;
pathology
;
radiotherapy
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Female
;
Follow-Up Studies
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Gene Expression Regulation, Neoplastic
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Humans
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Hypoxia-Inducible Factor 1, alpha Subunit
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metabolism
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Inhibitor of Apoptosis Proteins
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Lymphatic Metastasis
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Male
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Microtubule-Associated Proteins
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metabolism
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Middle Aged
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Neoplasm Staging
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Paraffin Embedding
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Survival Rate
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Vascular Endothelial Growth Factor A
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metabolism
5.Clinicopathological characteristic of lymphomatoid granulomatosis.
Chun-nian HE ; Jing ZHANG ; Guo-chen DUAN
Chinese Journal of Pathology 2007;36(5):336-338
Adrenal Cortex Hormones
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therapeutic use
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Antiviral Agents
;
therapeutic use
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Diagnosis, Differential
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Granulomatosis with Polyangiitis
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diagnosis
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Humans
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Lung Neoplasms
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diagnostic imaging
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drug therapy
;
pathology
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Lymphomatoid Granulomatosis
;
diagnostic imaging
;
drug therapy
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pathology
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Prognosis
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Radiography
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Sarcoidosis
;
diagnosis
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Tuberculosis, Pulmonary
;
diagnosis
6.Essentials of pharmacophylogeny: knowledge pedigree, epistemology and paradigm shift.
Da-cheng HAO ; Pei-gen XIAO ; Li-wei LIU ; Yong PENG ; Chun-nian HE
China Journal of Chinese Materia Medica 2015;40(17):3335-3342
Chinese materia medica resource (CMM resource) is the foundation of the development of traditional Chinese medicine. In the study of sustainable utilization of CMM resource, adopting innovative theory and method to find new CMM resource is one of hotspots and always highlighted. Pharmacophylogeny interrogates the phylogenetic relationship of medicinal organisms (especially medicinal plants), as well as the intrinsic correlation of morphological taxonomy, molecular phylogeny, chemical constituents, and therapeutic efficacy (ethnopharmacology and pharmacological activity). This new discipline may have the power to change the way we utilize medicinal plant resources and develop plant-based drugs. Phylogenomics is the crossing of evolutionary biology and genomics, in which genome data are utilized for evolutionary reconstructions. Phylogenomics can be integrated into the flow chart of drug discovery and development, and extends the field of pharmacophylogeny at the omic level, thus the concept of pharmacophylogenomics could be redefined in the context of plant pharmaceutical resources. This contribution gives a brief discourse of knowledge pedigree of pharmacophylogeny, epistemology and paradigm shift, highlighting the theoretical and practical values of pharmacophylogenomics. Many medicinally important tribes and genera, such as Clematis, Pulsatilla, Anemone, Cimicifugeae, Nigella, Delphinieae, Adonideae, Aquilegia, Thalictrum, and Coptis, belong to Ranunculaceae family. Compared to other plant families, Ranunculaceae has the most species that are recorded in China Pharmacopoeia (CP) 2010. However, many Ranunculaceae species, e. g., those that are closely related to CP species, as well as those endemic to China, have not been investigated in depth, and their phylogenetic relationship and potential in medicinal use remain elusive. As such, it is proposed to select Ranunculaceae to exemplify the utility of pharmacophylogenomics and to elaborate the new concept empirically. It is argued that phylogenetic and evolutionary relationship of medicinally important tribes and genera within Ranunculaceae could be elucidated at the genomic, transcriptomic, and metabolomic levels, from which the intrinsic correlation between medicinal plant genotype and metabolic phenotype, and between genetic diversity and chemodivesity of closely related taxa, could be revealed. This proof-of-concept study regards pharmacophylogenomics as the updated version of pharmacophylogeny and would enrich the intension and spread the extension of pharmacophylogeny. The interdisciplinary knowledge and techniques will be integrated in the proposed study to promote development of CMM resource discipline and to boost sustainable development of Chinese medicinal plant resources.
China
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Drugs, Chinese Herbal
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chemistry
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pharmacology
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Knowledge
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Medicine, Chinese Traditional
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Phylogeny
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Plants, Medicinal
;
chemistry
;
classification
;
genetics
7.Paneth cell-rich carcinoma of stomach: report of two cases.
Wei-dong SHI ; Chun-nian HE ; Jin-ping ZHAI ; Jin-hai SUN ; Chen CHEN
Chinese Journal of Pathology 2006;35(2):123-124
Adenocarcinoma
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pathology
;
surgery
;
Aged
;
Carcinoma, Signet Ring Cell
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pathology
;
surgery
;
Cell Differentiation
;
Female
;
Follow-Up Studies
;
Gastrectomy
;
methods
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Humans
;
Male
;
Middle Aged
;
Paneth Cells
;
pathology
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Stomach Neoplasms
;
pathology
;
surgery
8.Pulmonary epithelioid hemangioendothelioma: report of a case.
Huan-fen ZHAO ; Chun-nian HE ; Ping LI ; Jin-ping ZHAI ; Xiu-zhi ZHANG
Chinese Journal of Pathology 2010;39(4):277-277
Adenocarcinoma, Bronchiolo-Alveolar
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metabolism
;
pathology
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Antigens, CD34
;
metabolism
;
Diagnosis, Differential
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Female
;
Hemangioendothelioma, Epithelioid
;
metabolism
;
pathology
;
surgery
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Hemangioma
;
metabolism
;
pathology
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Hemangiosarcoma
;
metabolism
;
pathology
;
Humans
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Lung Neoplasms
;
metabolism
;
pathology
;
surgery
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Middle Aged
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Vimentin
;
metabolism
9.Trial study on design of irradiated fields of radiotherapy in cervical and upper thoracic esophageal cancer
Hui LIU ; Zhi-Fan ZENG ; Nian-Ji CUI ; Zhi-Chun HE ; Shao-Min HUANG ;
Chinese Journal of Radiation Oncology 1992;0(04):-
Objective To compare three kinds of irradiation treatment plans for cervical and upper thoracic esophageal cancer,in order to arrived at proper decision for the patient.Methods From February 2001 to June 2004,43 such patients were studied with three different simulated treatment plans made including conformal plan,conventional four-field plan and conventional two-field plan for every one.All plans were evaluated with iso- dose curve and dose-volume histogram.Results GTV on 95% isodose curve was 99.5%,98.2% and 87.4% in conforaml plan,conventional four-field plan and conventional two-field plan,respectively;PTV_1 and PTV_2 on 95% isodose with 97.8%,97.2%,94.8% and 95.8%,86.6%,73.7%.The volume of>20 Gy dose of left lung accepted was 18.6%,17.2% and 32.3%,in conformal plan,conventional four-field plan and conventional two-field plan,respectively;the right lung received 20.5%,19.9% and 35.5%.Conclusions Conformal plan is the best in radiotherapy,as it can provide ideal dose distribution of irradiated target with adequate protection of the normal tissues.Conventional four-field plan,being easy to carry out,can replace the conformal plan in most situations.Conventional two-field has the most uneven dose distribution and largest lung volume irradiated.
10.Pharmaphylogeny vs. pharmacophylogenomics: molecular phylogeny, evolution and drug discovery.
Da-cheng HAO ; Pei-gen XIAO ; Ming LIU ; Yong PENG ; Chun-nian HE
Acta Pharmaceutica Sinica 2014;49(10):1387-1394
With the surge of high-throughput sequencing technology, it is becoming popular to perform the phylogenetic study based on genomic data. A bundle of new terms is emerging, such as phylogenomics, pharmacophylogenomics and phylotranscriptomics, which are somewhat overlapping with pharmaphylogeny. Phylogenomics is the crossing of evolutionary biology and genomics, in which genome data are utilized for evolutionary reconstructions. Pharmaphylogeny, advocated by Prof. Pei-gen Xiao since 1980s, focuses on the phylogenetic relationship of medicinal plants and is thus nurtured by molecular phylogeny, chemotaxonomy and bioactivity studies. Phylogenomics can be integrated into the flow chart of drug discovery and development, and extend the field of pharmaphylogeny at the omic level, thus the concept of pharmacophylogenomics could be redefined. This review gives a brief analysis of the association and the distinguished feature of the pharmaphylogeny related terms, in the context of plant-based drug discovery and sustainable utilization of pharmaceutical resource.
Drug Discovery
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Pharmacogenetics
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Phylogeny
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Plants, Medicinal
;
chemistry
;
genetics