1.Correlation between ultrasonic characteristics of carotid artery plagues and risk factors of diabetes mellitus type 2
Zhen-zhen, CHENG ; Jian-hua, WANG ; Gui-chun, DING
Chinese Journal of Medical Ultrasound (Electronic Edition) 2013;(6):465-469
Objective To evaluate the relationship between carotid artery plagues and the clinical risk factors in patients with diabetes mellitus type 2 by observing the ultrasonic characteristics of carotid atherosclerosis plagues.Methods The ultrasound results of carotid arteries in 665 patients with diabetes mellitus type 2 from January 2009 to December 2011 in Beijing Amery General Hospital were retrospectively analyzed.The location and quantity of carotid atherosclerotic plaques were observed .The relationship between the occurrence and risk factors of diabetes such as hypertension ,family history of diabetes and age were analyzed.Single factor and multi-factor analysis were applied for the related risk factors .Results The ultrasonography showed 405 cases of carotid artery plaques.Most carotid artery plaques were located in the posterior wall of carotid sinus and were hyperechoic ,hypoechoic or isoechoic.The single factor analysis showed hypertension,family history of diabetes and age are risk factors of carotid atherosclerosis (χ2 =42.322,9.682 and 140.658,all P<0.01).Multi-factor logistic regression analysis showed age was an independent risk factor of carotid atherosclerosis in patients with diabetes mellitus type 2.The risk factors scores of patients who were less than 45 years,45-65 years and over 65 years of age were (3.50 ±1.16)scores,(3.46 ±0. 92)scores and (3.21 ±0.88)scores,and the difference was statistically significant (F=5.781,P<0.001). There were significant differences between risk factors scores of different age groups ( t =2.084,2.002, 3.786,3.474,2.877 and 2.504,all P<0.05).In patients more than 65 years of age,the risk of atherosclerosis plaques is 28.732 times higher than that of patients less than 45 years of age.After controlling the age factor,the possibility of atherosclerosis plaque increased 1.201 times for each additional one point of score. Conclusions Most carotid artery plaques in patients with diabetes mellitus type 2 are located in the posterior wall of carotid sinus and are hyperechoic ,hypoechoic or isoechoic.Age is an independent risk factor for the formation of carotid plaque.Patients more than 45 years of age should undergo early intervention to avoid the occurrence of major vascular complications .
2.Two special cerebral hyponatremia.
Xiang-zhen NAN ; Yong-qing WANG ; Chun-xue YAN
Chinese Journal of Pediatrics 2003;41(9):715-717
4.Quantitative analysis of the reaching ability of stroke survivors with synchronous surface electromyography
Chun LUO ; Bin XIE ; Zhen HUANG ; Caifeng WANG ; Jiankang WU
Chinese Journal of Physical Medicine and Rehabilitation 2017;39(4):253-258
Objective To assess the reaching ability of hemiplegic stroke survivors using a motion capture unit (MCU) combined with surface electromyography (sEMG).Methods Sixteen stroke survivors with hemiplegia formed the experimental group,while healthy counterparts were selected as the control group.Both groups were asked to sit on a chair and reach for a cup on a table in front of their shoulder at arm's length using their affected arms in the experimental group and their right arms in the control group.MCUs were fixed on their spines and arms to obtain kinematic signals,and the sEMG signals of the trapezius,the anterior deltoids,biceps and triceps of the tested limb were recorded.Each subject repeated the test 3 times,and the best result was retained for further analysis.After signal processing,the range of movement of the shoulders and elbows was extracted along with the time used to reach the cup,peak angular velocity,time to peak velocity of the shoulders and elbows,work of the muscles and work ratios of the trapezius/deltoid and biceps/triceps.The upper limb section of the Fugl-Meyer assessment (FMA) was also administered to evaluate the patients' upper limb function.Independent sample rank sum tests compared the patients with the controls in terms of kinematics and sEMG parameters.Spearman analysis was used to explore the correlation between the FMA scores and the kinematics and sEMG characteristics.Results Significant differences in the kinematic and myoelectric indicators were found between the patients and the controls.The average FMA score of the patients was correlated with the peak velocity of the shoulder joint.Moreover,the ROM of the shoulder was closely related to the work of the trapezius,while the time for the shoulder joint to reach peak velocity was closely related to the work ratio of the biceps and triceps.Conclusion An MCU integrated with synchronous sEMG can quantitatively assess the kinematics and kinetics of hemiplegic stroke survivors,at least in reaching.This can provide objective guidance to optimize clinical rehabilitation.
5.Research progress of Mongolian medicine digeda.
Chun-Hong ZHANG ; Chensuyile ; Na ZHANG ; Ping LONG ; Zhen-Hua LI ; Hong ZHU ; Zhen-Wang WANG ; Min-Hui LI
China Journal of Chinese Materia Medica 2013;38(24):4362-4368
Traditional Mongolian medicine Digeda processes a significant importance in clinical therapy with notably actions of heat-clear and detoxication effects. This paper intends to provide comprehensive insight into the species textual research, chemical constituents, qualitative identification, pharmacology and clinical application of Mongolian medicine Digeda to provide valuable data for further studies and the development of clinical applications of these medicinal plants.
Geography
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Humans
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Medicine, Mongolian Traditional
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methods
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Pharmacology
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Plants, Medicinal
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growth & development
6.Benign metastasizing leiomyma of lung: report of a case.
Li-juan WANG ; Zhen-zhu SUN ; Dong-ming LENG ; Chun WANG ; Xiao-feng YANG
Chinese Journal of Pathology 2008;37(2):143-144
Adult
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Female
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Humans
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Leiomyoma
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complications
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Lung Neoplasms
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complications
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Uterine Neoplasms
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complications
7.Qualitative and quantitative detection of Poria cocos by near infrared reflectance spectroscopy.
Xiao-huan FU ; Jun-hua HU ; Jia-chun LI ; Yin-hua DING ; Zhen-zhong WANG ; Wei XIAO ; Zhen-qiu ZHANG
China Journal of Chinese Materia Medica 2015;40(2):280-286
OBJECTIVEThe present study is concerning qualitative and quantitative detection of Poria cocos quality based on FT-near infrared (FT-NIR) spectroscopy combined with chemometrics.
METHODThe Poria cocos polysaccharides contents were determined by UV. Transmission mode was used in the collection of NIR spectral samples. The pretreatment method was first derivation and vector normalization. Then principal component analysis (PCA) was used to build classification model and partial least square (PLS) to build the calibration model.
RESULTThe results showed that conventional criteria such as the R, root mean square error of calibration (RMSEC), and the root mean square error of prediction (RMSEP) are 0.944 0, 0.072 1 and 0.076 2, respectively. The misclassified sample is 0 using the qualitative model built by PCA.
CONCLUSIONThe prediction models based on NIR have a better performance with high precision, good stability and adaptability and can be used to predict the polysaccharose content of Poria cocos rapidly, which can provide a fast approach to discriminate the different parts of Poria cocos.
Fungal Polysaccharides ; analysis ; Least-Squares Analysis ; Poria ; chemistry ; Principal Component Analysis ; Spectroscopy, Near-Infrared ; methods
8.Eye model for inspecting the functional vision of IOLs
Ren-Feng, XU ; Zhen-Ping, HUANG ; Hua-Chun, WANG ; De-Gao, ZHAO ; Liang, DING ; Chun-Yan, XUE ; Yong, WU
International Eye Science 2006;6(6):1233-1236
· AIM: To inspect and compare the functional vision of an aspheric intraocular lens (Tecnis) with those of conventional monofocal silicone and acrylic intraocular lens and multifocal intraocular lens (Array).· METHODS: The IOLs were tested in the eye model, which was designed to be optically equivalent to the theoretical eye model. The eye model is a combination of a spherical photographic lens with 35mm focal length ( IOL put in a water cell)and a charge coupled device (CCD) camera. The images constructed by the lenses are observed on a monitor of personal computer and the contrasts of the images are analyzed by using commercial image processing software.· RESULTS: The modulation transfer function of the eye model equals the scale produced by the theoretical eye model. The images constructed by changing the diameter of aperture stop and IOL.· CONCLUSION: The proposed eye model is useful for testing functional vision and for inspecting differences of intraocular lens.
9.Advance in studies on natural antidepressant drugs and cytochrome P450.
Lu ZHANG ; Fei-hu WANG ; Sai-zhen CHEN ; Jian-chun PAN
China Journal of Chinese Materia Medica 2015;40(5):828-832
In the fast pace of modern life and under the heavy work pressure, the prevalence of depression has increased year by year. Meanwhile, the demands for antidepressant drugs have also grown, especially the high-efficiency and low-toxicity natural antidepressant drugs, mainly including polyphenols, flavonoids, organic acids, alkaloids and terpenoids. Cytochrome P450 (CYP450) is a type of enzymes involving oxidative metabolism of drugs in vivo, and can change the pharmacokinetics and efficacy of drugs. Therefore, it is of important significant to define the effect of natural antidepressant drugs on CYP450 in human bodies, in order to improve the rational clinical medication, avoid drug interactions and reduce adverse reactions.
Animals
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Antidepressive Agents
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pharmacology
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Cytochrome P-450 Enzyme Inhibitors
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pharmacology
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Cytochrome P-450 Enzyme System
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metabolism
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Depression
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drug therapy
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enzymology
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Drugs, Chinese Herbal
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pharmacology
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Humans
10.Meningeal melanocytoma with nevus fuscoceruleus ophthalmomaxillaris: report of a case.
Chun WU ; Hai WANG ; Qun-li SHI ; Heng-hui MA ; Zhen-feng LU
Chinese Journal of Pathology 2011;40(3):194-195
Adult
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Diagnosis, Differential
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Humans
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MART-1 Antigen
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metabolism
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Magnetic Resonance Imaging
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Male
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Medulloblastoma
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metabolism
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pathology
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Melanocytes
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pathology
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Melanoma
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diagnosis
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metabolism
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pathology
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surgery
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Melanoma-Specific Antigens
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metabolism
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Meningeal Neoplasms
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diagnosis
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metabolism
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pathology
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surgery
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Neoplasms, Multiple Primary
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diagnosis
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metabolism
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pathology
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surgery
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Neurilemmoma
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metabolism
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pathology
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Nevus of Ota
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diagnosis
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metabolism
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pathology
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surgery
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S100 Proteins
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metabolism
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Skin Neoplasms
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diagnosis
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metabolism
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pathology
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surgery
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Vimentin
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metabolism