1. Current advances in understanding neuroprotective effect of acteoside in neurodegenerative disease
Dan-Dan HAO ; Feng-Ning ZHANG ; Chun-Ying BAI ; Chun-Ying SIRIGULENG ; Yun RUI ; Lei ZHANG ; Wei-Hong LANG ; Guan-Hua DU ; Hong-Quan WANG
Chinese Pharmacological Bulletin 2021;37(7):906-910
Acteoside is among the most widespread of thedisaccharide caffeoyl esters that are widely distributed in the plant kingdom with diverse biological activities. Recent studies have shown that acteoside has neuroprotective activity in neurodegenerative diseases. This review examines and extrapolates from the recent literature to build support for the use of acteoside in mitigating neuropathy in neurodegenerative disease, including Parkinson ' s disease (PD) and Alzheimer' s disease (AD). We summarize the main pharmacokinetic parameters of acteoside in animals after different administration routes. Meanwhile, we point out both problems and shortcomings, and highlight its future development trend.
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