No abstract available.
Humans ; Methacholine Chloride* ; Rhinitis*

Teratomas are rare neoplasms, constituting 0.5% to 1.2% of all intracranial tumors;nevertheless, they account for 2% to 4% of intracranial tumor in children. The most common location for these tumor is in the midline pineal region, but teratoma in the lateral ventricle is very rare. A report is presented here of the total extirpation of a huge sized teratoma located in the lateral ventricle of a 4-year old man. This unique tumor is revealed various tissue components, ectodermal and mesodermal derivatives such as skin appendages and neuroglial tissue partially lined by ependmal cells.
Child ; Child, Preschool ; Ectoderm ; Humans ; Lateral Ventricles ; Mesoderm ; Skin ; Teratoma*

Colloid cyst of the third ventricle is rare intracranial lesion. It has been estimated that they comprise approximately 0.55% of all tumors of the brain. A new interest has been developed in this lesion, which is completely benign histologically but, because of its deep and strategic location, poses a difficult therapetic problem. The contrast between the histological benignancy and the risk of morbidity and mortality associated with often surgical exploration and removal has led to alternative procedures. We reported here a 33-year-old male patient with colloid cyst of the third ventricle presenting with headache and vomiting. Who was treated by stereotacic removal utilizing CRW stereotactic system and followed up post-operatively for more than 3 years.
Adult ; Brain ; Colloid Cysts* ; Colloids* ; Headache ; Humans ; Male ; Mortality ; Third Ventricle* ; Vomiting

OBJECTIVE: The aim of this study is to find out the genes which are related to ovarian cancer cell growth using large circular antisense library. METHODS: Clones for antisense library were uni-directionally sub-cloned into pBS SK (-) vector. LC-antisense molecules were then purified from the culture supernatants of the bacterial competent cells superinfected with M13K07 helper bacteriophages. The LC-antisense library to 240 unigene clone was constructed and utilized in the identification of genes functionally involved in the growth of ovarian cancer cells. RESULTS: The 17 numbers out of the 240 numbers of the antisense library exerted a marked inhibitory effect on the growth of SK-OV 3. CONCLUSION: The putative functional categorization of each gene was then conducted via public databases. These candidates may be used as target genes for drug development or adjuvant of conventional chemotherapeutic drugs.
Bacteriophages ; Clone Cells ; Estrone ; Gene Targeting ; Genetic Therapy ; Ovarian Neoplasms

Intracranial cavernous hemangioma is one of vascular malformations composed of thin walled sinusoidal spaces lined with endothelium. The authors described 7 cases of cavernous hemangioma that were verified histologically and 5 lesions that were diagnosed only with symptoms, radiological and magnetic resonance imaging(MRI) findings. The clinical features are as follows:7 patients had seizures, 3 focal neurological signs and 2 intracaranial hematomas. Computed tomography(CT) usually demonstrated nodular or irregular hyperdense lesions without significant mass effect. MRI usually revealed central area of mixed signal intensity and peripheral rim of low signal intensity. Angiography usually showed an avascular area or normal angiographic appearance. The combination of a clinical history with CT, angiography and MRI findings would suggest cavernous hemangioma. Four epilepsy patients underwent surgical procedures, resulting in improved seizure control and/or lessened neurological deficit.
Angiography ; Endothelium ; Epilepsy ; Hemangioma, Cavernous* ; Hematoma ; Humans ; Magnetic Resonance Imaging ; Seizures ; Vascular Malformations

Labrune’s syndrome, or leukoencephalopathy with brain calcifications and cysts (LCC), is a rare genetic syndrome with variable neurological presentations. Psychiatric manifestations and involuntary movements are uncommonly reported. We report the case of a 19-year-old female, initially diagnosed with Fahr’s syndrome, who presented to us with acute psychosis, abnormal behavior and involuntary movements. Her brain computed tomography showed extensive bilateral intracranial calcifications without cysts. Genetic testing detected two compound heterozygous variants, NR_033294.1 n.*9C>T and n.24C>T, in the SNORD118 gene, confirming the diagnosis of LCC. We discuss the expanding phenotypic spectrum of LCC and provide a literature review on the current diagnosis and management of this rare syndrome.

Spontaneous intracranial hematoma in patients with brain tumors is well recognized, However, intracranial hematoma associated with meningioma has been rarely reported. Not infrequently, clinical manifestations of such tumors have been masked by the associated hematoma, which preclude correct diagnosis of these tumors. Meningioma-associated hemorrhages have been reported regardless of sex, age, or location and histology of the tumor. The mechanisms of such hemorrhage are yet to be clarified. During the last two years, we have experienced three cases of intracranial hemorrhage associated with meningioma. Two of them occurred acutely without antecedent symptoms of the meningioma and other one after gamma knife surgery of meningioma. We reviewed partinent literature and discussed possible mechanisms of these rare intratumoral or peritumoral hemorrhages associated with meningiomas.
Brain Neoplasms ; Diagnosis ; Hematoma* ; Hemorrhage ; Humans ; Intracranial Hemorrhages ; Masks ; Meningioma*

Primary CNS rhabdoid tumor is an extremely rare malignant tumor affecting children. Clinical, radiological, and histopathological features of malignant rhabdoid tumor are presented. Following the complete extirpation of a large tumor at the frontoparietal region, a 16-year-old male patient suffered from several local recurrences. The neoplasm is, defined by its histopathological and ultrastructural characteristics and by the pattern of its antigenicity as a malignant rhabdoid tumor(MRT).
Adolescent ; Child ; Humans ; Male ; Recurrence ; Rhabdoid Tumor*

BACKGROUND AND OBJECTIVES: Platelet activation and aggregation, with resultant arterial thrombus formation, play pivotal roles in the pathophysiology of acute coronary syndrome (ACS). The efficacy of tirofiban, a specific inhibitor of the platelet glycoprotein IIb/IIIa receptor, combined with heparin, or low molecular heparin (LMWH), in the management of ACS were evaluated. SUBJECTS AND MEHTODS: One hundred seventeen patients (60.8+/-10.9 years, 76 male), with unstable angina or non-ST elevation myocardial infarction, who had ST-T changes and elevated troponin, were divided into 4 groups : Group I (n=30 : heparin alone), Group II (n=28 : LMWH, dalteparin alone), Group III (n=29 : tirofiban combined with heparin) and Group IV (n=30 : tirofiban with LMWH). The major adverse cardiac events (MACE) among the 4 groups, during 6-month clinical follow-ups, were compared. RESULTS: Percutaneous coronary intervention, or a coronary artery bypass graft, was performed in 23, 19, 19 and 22 patients from Groups I, II, III and IV, respectively (p=0.87). A minor bleeding complication developed in 2 (6.7%), 1 (3.6%), 1 (3.4%) and 2 patients (6.7%) in groups I, II, III and IV, respectively (p=0.79). During the six-month follow-up MACE occurred in 7 (30.4%), 6 (31.6%), 3 (15.8%) and 4 patients (18.2%) in groups I, II, III and IV, respectively (p=0.02 : Group I and II vs. Group III and IV). CONCLUSION: Tirofiban combined with LMWH is safe and may improve the long-term prognosis of patients with ACS.
Acute Coronary Syndrome* ; Angina, Unstable ; Angioplasty ; Blood Platelets* ; Coronary Artery Bypass ; Dalteparin ; Follow-Up Studies ; Glycoproteins* ; Hemorrhage ; Heparin ; Heparin, Low-Molecular-Weight* ; Humans ; Myocardial Infarction ; Percutaneous Coronary Intervention ; Platelet Activation ; Prognosis ; Thrombosis ; Transplants ; Troponin

BACKGROUND: Expression of mutant p53 has been observed in a variety of human cancers, including head and neck squamous cell carcinoma and carcinoma of breast, colon, esophagus, lung, stomach, liver, thyroid, etc. OBJECTIVES: To establish expression frequency of p53 and correlation between p53 expression and clinicopathologic data in squamous cell carcinoma of head and neck. MATERIALS AND METHODS: Fresh tissue samples were obtained from 66 patients with squamous cell carcinoma of head and neck undergoing biopsy or surgery. Expression of mutant p53 was evaluated by immunohistochemical staining with anti-p53 monoclonal antibody in 66 paraffin-embedded tissues of squamous cell carcinoma in head and neck. The studies consisted of 13 cases of oral carcinoma including tongue, 10 cases of pharyngeal carcinoma and 43 cases of laryngeal carcinoma. RESULTS: 1) The frequency of p53 expression in squamous cell carcinoma of head and neck was 48.5%((31/66). 2) The frequency of p53 expression by tumor site was 42.6%(6/13) in oral cavity, 60%(6/10) in pharynx and 44.2%(19/43) in larynx. 3) A positive relationship was seen between p53 expression and lymphnode metastasis, representing 69.2% p53 expression in metastasis group and 16.7% p53 in non-metastasis group. CONCLUSION: Author was suggested that p53 expression in squamous cell carcinoma of head and neck was related to tumor progression and metastasis.
Biopsy ; Breast ; Carcinoma, Squamous Cell* ; Colon ; Esophagus ; Head* ; Humans ; Larynx ; Liver ; Lung ; Mouth ; Neck* ; Neoplasm Metastasis ; Pharynx ; Stomach ; Thyroid Gland ; Tongue