1.Analysis on detecting primary open angle glaucoma based on retinal nerve fiber layer and ganglion cell complex thickness
International Eye Science 2016;16(10):1886-1890
AIM:To investigate the peripapillary retinal nerve fiber layer ( RNFL ) thickness and the macular ganglion cell complex ( GCC ) thickness in primary open angle glaucoma ( POAG ) eyes and to compare them with normal control eyes, and to evaluate the diagnostic ability of peripapillary RNFL thickness and macular GCC thickness in POAG.
●METHODS:This was a cross-sectional study consisting of 56 POAG patients. The control group consisted of 60 normal subjects (60 eyes) were matched in terms of age, sex, diopter and axial length. The peripapillary RNFL thickness and the macular GCC thickness of POAG eyes and normal control eyes were measured and compared by RTVue-100 optical coherence tomography ( OCT ) . To assess the diagnostic utility of peripapillary RNFL thickness and macular GCC thickness in POAG, receiver operating characteristic curves ( ROC ) and areas under the ROC ( AUC) were used.
●RESULTS:The POAG eyes had a thinner peripapillary RNFL and macular GCC than the control eyes at all the regions ( P < 0. 001 ). Multivariable linear regression analysis showed that the peripapillary RNFL thickness and macular GCC thickness was significantly thinner in association with the POAG diagnosis. ROC and AUC analysis showed that the best AUC parameters were C/D (AUC=0. 936; 95% Cl=0. 903, 0. 964) and superior RNFL thickness (AUC=0. 910;95% Cl=0. 889, 9. 455). The AUC of nasal RNFL thickness, inferior RNFL thickness, temporal RNFL thickness, superior GCC thickness, inferior GCC thickness, and average GCC thickness were all above 0. 8 with a good diagnostic value.
●CONCLUSION:The peripapillary RNFL thickness and macular GCC thickness in POAG eyes are thinner than that of normal control eyes. Decreased peripapillary RNFL thickness and macular GCC thickness may be associated with POAG. The peripapillary RNFL thickness and macular GCC thickness have a good diagnostic value.
3.Comparison of medical student's mental workload between VDT and paper-based reading.
Xiao-Wu PENG ; Zhen-Cheng XU ; Xiao-Chun PENG
Chinese Journal of Industrial Hygiene and Occupational Diseases 2008;26(12):738-740
Adult
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Computer Terminals
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Humans
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Male
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Paper
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Reading
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Students, Medical
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Workload
4.Analysis on medication principles for cough based on experience of Xu Di-hua, descendant of Meng He Medical School.
Xiao-jing XU ; Li-min XU ; Chun-feng SHEN ; Cai-hua WANG ; Chun-ti SHEN
China Journal of Chinese Materia Medica 2015;40(21):4301-4305
Based on the software of traditional Chinese medicine inheritance support system (TCMISS), this article aims to analyze the experience and composition rules for cough from the descendant of Meng He Medical School, Xu Di-hua. The cough cases treated by Xu Di-hua were collected, and recorded into TCMISS (V2.0). Data mining methods such as Apriori algorithm and complex system entropy cluster were used to analyze the medication principles of Xu Di-hua for cough from pathogenesis and therapeutie aspects, and dig out the frequency of the herbs in prescription, core medicine and new combinations. The experience of curing cough from Professor Xu Di-hua were well found in the research. He is good at choosing prescriptions accurately, and pays attention to simultaneous use of cold and moisture drugs with combination of tonification and purgation. He is skilled in adding or reducing materia medica flexibly, as well as regulating lung to relieve cough and eliminating phlegm by clearing heat.
Algorithms
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Cough
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drug therapy
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Data Mining
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Drug Therapy, Combination
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Drugs, Chinese Herbal
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chemistry
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therapeutic use
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Female
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Humans
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Male
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Materia Medica
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Medicine, Chinese Traditional
5.Development of Chinese Version of QLQ-STO22
Bao-Fa JIANG ; Tao XU ; Chun-Xiao LIU ; Al ET ;
Chinese Mental Health Journal 1991;0(05):-
Objectives:To translate the English version of Quality of Life Questionnaire of Stomach 22 into Chinese,and to test the reliability and validity of the Chinese Version of QLQ-STO22.Methods:From 1st June to 31st December,2003,140 patients with gastric cancer were sampled as study participants in three hospitals using cluster sampling method.All participants were interviewed with QLQ-STO22 Chinese version by the investigators who were trained in advance.Results:Nearly all ICCs of scales of STO22 were above 0.75;the split-half reliability coefficient is 0.78 and the Cronbach'a coefficient is 0.80.These results proved that the questionnaires had good test-retest reliability,split-half reliability and internal consistency.Three common factors were extracted by factor analysis,which ccould account for more than 60% of total variance and factor loads of the three common factors were above 0.5 in related items.Conclusion:QLQ-STO22 has good reliability and validity,which is available for the study of life quality among Chinese gastric cancer patients.
6.Hypoxia enhances stemness of cancer stem cells in glioblastoma
Pengcheng LI ; Chun ZHOU ; Lunshan XU ; Hualiang XIAO
Journal of Regional Anatomy and Operative Surgery 2015;(5):479-483
Objective To investigate the relationship between hypoxia and stemness of cancer stem cells ( CSCs ) . Methods U87 cells,U251 cells and primary glioma cells were experienced hypoxia. Detected the ultrastructure of these cancer cells with transmission elec-tron microscopy;detect the cell growth with MTT assay;cell cycle and CD133 expression were detected by flow cytometry;and the cell mi-gration ablity were detected through transwell chamber assay;the colony-forming efficiency were deteced by colony-forming assay; and real-time quantitative PCR and Western blot were carried out to detect the mRNA and protein expression of markers of stem cells and their differ-entiation respectively. Results Hypoxia maintained the undifferentiated state of primary glioma cells, slowed down the growth of glioma cells which were in a relatively quiescent stage, increased the colony forming efficiency and migration of glioma cells, and increased the expression of markers of stem cells, but the expression of markers for stem cell differentiation was reduced after hypoxia treatment. Conclusion Hypoxi-a may induce the “dedifferentiation” of differentiated glioma cells which then acquire the stemness.
7. Role of inflammation in the carcinogenesis of colorectal cancer
Academic Journal of Second Military Medical University 2013;34(1):78-82
Colorectal cancer is one of the most common malignant tumors. Previous epidemiological and molecular biological studies have suggested that inflammation plays a pivotal role in the pathogenesis of colorectal cancer. Moreover, many studies have been focused on molecular pathways of inflammation in colorectal cancer. However, the explicit mechanisms involved remain to be fully elucidated. The identification of the key inflammatory mechanisms may provide new targets for intervention and treatment of colorectal cancer. Here we reviewed the inflammatory mechanisms relevant to the carcinogenesis of colorectal cancer, hoping to cast new lights on future research.
8.Some experiences in the treatment for trichloroethylene-induced medicamentosa like dermatitis.
Feng-ling ZHAO ; Xiao-li WANG ; Xue-chun XU ; Chun-he WEN
Chinese Journal of Industrial Hygiene and Occupational Diseases 2004;22(3):229-230
Adolescent
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Adult
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Dermatitis, Occupational
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etiology
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therapy
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Drug Eruptions
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etiology
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therapy
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Female
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Humans
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Male
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Methylprednisolone
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therapeutic use
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Trichloroethylene
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adverse effects
9.Drugs and drug delivery strategies for treatment of pulmonary arterial hypertension
Xiao-hong JIANG ; Xu-yang XING ; Xiao-chun WANG ; Li-fang YIN ; Wei HE
Acta Pharmaceutica Sinica 2021;56(5):1332-1342
Pulmonary arterial hypertension (PAH), also named as a cancer of cardiovascular disease, is a rare disease and has complicated pathogenesis. Recently, there are more understandings of PAH pathogeneses. According to the pathogenesis and active pathways, the clinically used drugs are classified into several groups incluidng prostacyclin analogues and prostacyclin receptor agonists, endothelin receptor antagonists, phosphodiesterase-5 inhibitors, soluble guanylate cyclase inhibitors,
10.Immunigical effect of CpG oligodeoxynucleotide as immune adjuvant of hepatitis B vaccine on pregnant mice and neonatal mice
xin, XIAO ; chun-guang, XU ; ai-hua, XIONG ; jian-wei, JIANG ; yan-fang, XU
Journal of Applied Clinical Pediatrics 1992;0(06):-
0.05); serum HBsAb levels of pregnant mice and neonatal mice in group with CpG-1826 (20 ?g)+hepatitis B vaccine significantly higher than those in group with CpG-1826 (10 ?g, 40 ?g)+ hepatitis B vaccine,hepatitis B vaccine and control respectively(P0.05).Conclusions Combination injection of CpG-1826 20 ?g and hepatitis B vaccine can markedly increase serum antibody levels of pregnant mice and neonatal mice, but don′t affect the survival quantity, the growth and development of neonatal mice.CpG-1826 is an ideal immune adjuvant for neonates with immature immune system during pregnancy.