1.Impact of Chronic Kidney Disease on Long-Term Outcome in Coronary Bypass Candidates Treated with Percutaneous Coronary Intervention.
Jian Rong PENG ; Chi Jen CHANG ; Chun Li WANG ; Ying Chang TUNG ; Hsin Fu LEE
Korean Circulation Journal 2017;47(1):50-55
BACKGROUND AND OBJECTIVES: The aim of this study was to identify clinical, lesional, and procedural predictors for adverse outcomes of coronary angioplasty and stenting in coronary bypass candidates. SUBJECTS AND METHODS: This cohort study included 107 consecutive candidates for coronary artery bypass surgery who underwent percutaneous coronary intervention with multiple coronary stents between Jan 2004 and Dec 2011. The study endpoint was major adverse cardiovascular events (MACEs) including all-cause mortality, nonfatal myocardial infarction, repeat revascularization, and stent thrombosis. Follow up was from the date of index percutaneous coronary intervention to the date of the first MACE, date of death, or December 31, 2015, whichever came first. RESULTS: In this study (age 62.3±11.2 years, 86% male), 38 patients (36%) had MACE. Among baseline, angiographic, and procedural parameters, there were significant differences in lower left ventricular ejection fraction (LVEF) and worse renal function. In a Cox regression model, LVEF and chronic kidney disease (CKD) were significant predictors for MACE. After a multivariate adjustment, CKD remained a significant predictor of MACEs (hazard ratio: 2.97, 95% confidence interval: 1.50-5.90). CONCLUSIONS: For coronary bypass candidates who were treated with coronary angioplasty and stenting, CKD seems to be the strongest predictor for adverse outcomes compared with other traditional factors.
Angioplasty
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Cohort Studies
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Coronary Artery Bypass
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Coronary Artery Disease
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Follow-Up Studies
;
Humans
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Mortality
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Myocardial Infarction
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Percutaneous Coronary Intervention*
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Renal Insufficiency, Chronic*
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Stents
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Stroke Volume
;
Thrombosis
2.Reversing of donor chimeras by stopping use of CsA in 2 CML patients relapsed after transplantation.
Chang-Rong NING ; Hong-Hua LI ; Chun-Ji GAO ; Li YU
Journal of Experimental Hematology 2007;15(3):640-642
The purpose of study was to evaluate the effect of stopping use of cyclosporine A (CsA) in reversion of donor chimeras of chronic myeloid leukemia (CML) patients relapsed after transplantation. Two CML patients were transplanted with allogeneic peripheral blood stem cells, and relapsed after transplantation, their bcr/abl gene and/or ph1 chromosome showed positive, donor chimeras decreased. For these two CML patients relapsed after transplantation, the use of CsA was stopped immediately, and the patient's body temperature, skin rash, blood picture, liver function and chimeras were planed to observe carefully. The results indicated that acute graft versus host disease (aGVHD) appeared in both patients. A hundred percent (100%) of donor chimeras were then found with bcr/abl gene and/or ph1 chromosome turning to negative in both patients. In conclusion, to stop using of CsA might be effective in the treatment of some CML patients relapsed after transplantation by reversing of donor chimeras and inducing graft-versus-leukemia (GVL) effect accompanied by GVHD.
Adult
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Antineoplastic Combined Chemotherapy Protocols
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therapeutic use
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Cyclosporine
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therapeutic use
;
Graft vs Leukemia Effect
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immunology
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Humans
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive
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drug therapy
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genetics
;
therapy
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Male
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Neoplasm Recurrence, Local
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genetics
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Peripheral Blood Stem Cell Transplantation
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adverse effects
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Transplantation Chimera
;
immunology
3.Efficacy of sublingual polyvalent bacterial vaccine (Lantigen B) in children with recurrent respiratory infection: a randomized double-blind controlled clinical trial.
Ai-huan CHEN ; Rong-chang CHEN ; Chun-qing ZHANG ; Denui CHEN ; Sui HUANG ; Yunen LIN ; Jieyi ZHAN ; Nanshan ZHONG
Chinese Journal of Pediatrics 2004;42(6):463-464
Administration, Sublingual
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Bacterial Vaccines
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administration & dosage
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immunology
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Child
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Child, Preschool
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Double-Blind Method
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Female
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Humans
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Immunoglobulin A
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blood
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Immunoglobulin A, Secretory
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analysis
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Male
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Pseudomonas Vaccines
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Recurrence
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Respiratory Tract Infections
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immunology
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prevention & control
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Treatment Outcome
4.Change of the expression level of Th1 and Th2 cytokines around the xenogeneic cancellous bone scaffold after transplantation: an experiment in rabbits.
Rong-chang LEI ; Xin-chun JIAN ; Zhi-qiang QIN
Chinese Journal of Plastic Surgery 2007;23(6):507-510
OBJECTIVETo observe the dynamic immunity of the porcine cancellous bone scaffold(PCBS) after transplantation and provide experimental evidences for amending and clinical use.
METHODSThe PCBS was gained through physical and chemical disposals to porcine cancellous bone and was implanted subcutaneously in rabbit. The histological investigation and the expression of Th1 (such as IL-2, IFN-gamma) and Th2 (such as IL-4, IL-10) mRNA were measured by HE, RT-PCR respectively in 1,2,4,8,12 week postoperation.
RESULTSHE revealed: Inflammation cells (lymphocytes and monocytes) were shown abundantly in the surrounding tissue in 1 week and were decreased gradually since 2 week. At 12 week, there were few inflammation cells in the surrounding tissue. RT-PCR revealed: The mRNA expression level of Th1 cytokines such as IL-2, IFN-gamma was high in 1 week and began to fall since 2 week. At 12 week, the mRNA expression level of Th1 cytokines was low; The mRNA expression level of Th2 cytokines such as IL-4, IL-10 was low in 1 week, rose gradually since 2 week and reached tiptop in 8 week. At 12 week, the mRNA of Th2 cytokines maintained high level expression.
CONCLUSIONSThe porcine cancellous bone scaffold excitate immunoreaction was transitory inflammation after implantation.
Animals ; Bone Transplantation ; immunology ; Cytokines ; metabolism ; RNA, Messenger ; genetics ; Rabbits ; Swine ; Th1 Cells ; metabolism ; Th2 Cells ; metabolism ; Tissue Scaffolds ; Transplantation, Heterologous
5.Expressions of tumor necrosis factor-converting enzyme and ErbB3 in rats with chronic obstructive pulmonary disease.
Chun-rong JU ; Xi-zheng XIA ; Rong-chang CHEN
Chinese Medical Journal 2007;120(17):1505-1510
BACKGROUNDChronic obstructive pulmonary disease (COPD) is associated not only with airway inflammation characterized by mucin hypersecretion but also with systemic inflammation. Tumor necrosis factor alpha (TNF-alpha) is found to take part in systemic inflammation, and ErbB3 plays an important role in mucin hypersecretion of COPD. Since TNF-alpha converting enzyme (TACE) is involved in the activation of both TNF-alpha and ErbB3, we established rat models of COPD to investigate the expressions of TACE, TNF-alpha and ErbB3 and to explore the correlations among TACE, TNF-alpha and ErbB3 respectively.
METHODSThirty Wistar male rats were randomly divided into COPD group (group C, n = 10), saline solution parallel group (group P, n = 8), and normal control group (group N, n = 8). Group C was challenged with passive cigarette smoking and intratracheal instillation of lipopolysaccharide. Six weeks later pulmonary functions were tested, bronchoalveolar fluid and arterial blood gases were assayed, and histopathological evaluations were performed in turn. The expressions of TACE, TNF-alpha and ErbB3 in lungs of all rats were determined histochemically.
RESULTSThe expressions of TACE, TNF-alpha and ErbB3 were significantly higher in group C than in group N (P < 0.01). The contents of TNF-alpha in serum (P < 0.01) and bronchoalveolar lavage fluid (BALF) (P < 0.01) were elevated more significantly in group C than in group N. A positive correlation existed between TACE and TNF-alpha (r = 0.784, P < 0.01) and between TACE and ErbB3 (r = 0.526, P < 0.01) respectively.
CONCLUSIONSTNF-alpha and ErbB3 are involved in the pathogenesis of COPD. TACE contributes to the progress of COPD indirectly through the function of TNF-alpha and ErbB3.
ADAM Proteins ; analysis ; physiology ; ADAM17 Protein ; Animals ; Bronchoalveolar Lavage Fluid ; chemistry ; Immunohistochemistry ; Lung ; physiopathology ; Male ; Pulmonary Disease, Chronic Obstructive ; metabolism ; pathology ; Rats ; Rats, Wistar ; Receptor, ErbB-3 ; analysis ; physiology ; Tumor Necrosis Factor-alpha ; analysis
6.Quadriceps strength assessed by magnetic stimulation of femoral nerve in patients with chronic obstructive pulmonary disease.
Chun-rong JU ; Rong-chang CHEN
Chinese Medical Journal 2011;124(15):2309-2315
BACKGROUNDSkeletal muscle dysfunction is one of important systemic manifestations of chronic obstructive pulmonary disease (COPD) and is associated with mortality in patients with COPD, thus quantifying its strength is of great clinical interest and of particular value. Quadriceps maximal volitional contraction (MVC) is often used for the routine measurements of this muscle's strength; while twitch tension (TwQ) evoked by magnetic stimulation of the femoral nerve has been employed for measurement of quadriceps strength non-volitionally. We aimed to investigate the prevalence and severity of skeletal muscle dysfunction in COPD patients by measurement of quadriceps strength with volitional and non-volitional techniques, and to probe into some methodological issues.
METHODSWe recruited 71 COPD patients and 60 control subjects. Quadriceps strength was measured with both maximality of TwQ and MVC force. The reproducibility for TwQ and MVC was investigated using within-occasion variability from three repeated maneuvers.
RESULTSMaximal TwQ was achieved in 121 participants at a mean of 90% of the stimulator's maximum output. The mean maximality of TwQ was decrease by about 44% - 47% in COPD patients as compared with controls (P < 0.05), so was MVC. There was a significant correlation between quadriceps TwQ and MVC, and the mean ratio of TwQ/MVC was 0.29 in controls and 0.33 in patients. The coefficient of variation showed that TwQ yielded lower within-occasion variability than MVC in both groups.
CONCLUSIONSQuadriceps strength is commonly and substantially impaired in patients with COPD, in terms of MVC as well as TwQ. The magnetic stimulation of the femoral nerve presents a higher reproducibility and is a better technique for measurement of quadriceps strength for the general population, especially for those who are too unwell to perform a full MVC; while it may not be applied to subjects who are over-weighted.
Aged ; Female ; Femoral Nerve ; physiology ; Humans ; Male ; Middle Aged ; Muscle Strength ; physiology ; Pulmonary Disease, Chronic Obstructive ; physiopathology ; Quadriceps Muscle ; physiology
7.Study of GRE-T_2 ~* WI MRI diagnosing microbleeding in stroke patients
Guo-Rong LIU ; Yue-Chun LI ; Ying HE ; Bao-Jun WANG ; Jing-Fen ZHANG ; Hui ZHANG ; Fu-Ru LIANG ; Chang-Chun JIANG ;
Chinese Journal of Neurology 2000;0(05):-
Objective To investigate the microbleeding incidence of healthy eldery population and patients with stroke.Methods 30 cases of healthy eldery population,32 cases of cerebral hemorrhage,46 cases of patients with ischemic cerebral vascular diseases were performed of MRI and GRE-T_2 ~* WI examination.Results The microbleeding incidences was 37.5% in cerebral hemorrhage group,28.1% in multiple cerebral infarction group,25.0% in Binswanger's disease group.The most frequently seen microbleeding foci located in ganglia areas,then in thalamus areas,subcortical areas and brain stem,last in cerebellar.Conclusion GRE-T_2 ~* WI,helpful for finding microbleeding and indicating lesion degree of microblooding vessels,plays an important role in the diagnosis of stroke and decision making of treatment.
8.The unbalance of anti-oxidation enzyme system and lipid peroxidation in acute high altitude sickness.
Chang-zheng JIANG ; Fang-ze LI ; Shu-yong SUN ; Mei'an HE ; Shu-yu ZHANG ; Rong LIAO ; Shu-ya JIA ; Hua-song ZENG ; Tang-chun WU
Chinese Journal of Industrial Hygiene and Occupational Diseases 2004;22(2):138-139
Acute Disease
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Adult
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Altitude Sickness
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blood
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enzymology
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Glutathione
;
blood
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Glutathione Peroxidase
;
blood
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Humans
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Lipid Peroxidation
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Male
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Military Personnel
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Nitric Oxide
;
blood
;
Nitric Oxide Synthase
;
blood
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Oxidoreductases
;
metabolism
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Superoxide Dismutase
;
blood
9.Classification and repairing investigation of the whistling deformities in the patients with bilateral cleft lip or bilateral cleft lip and cleft palate after primary cleft lip repair.
Xin-Chun JIAN ; Rong-Chang LEI ; Ping YIN
Chinese Journal of Plastic Surgery 2005;21(4):261-263
OBJECTIVETo classify the whistling deformities of the patients with bilateral cleft lip or bilateral cleft lip and cleft palate after primary cleft lip repair.
METHODSAccording to exposure degrees of the gum and the crown of the anterior upper incisors, 136 patients with whistling deformities after primary repair of bilateral cleft lip at the Department of Oral and Maxillofacial Surgery of Xiang Ya Hospital, Central South University were examined and the whistling deformities were classified into four grades. Grade I: the crowns of the left and the right upper incisors were exposed about one-second. Grade II: the whole crowns of the upper incisors were exposed or plus the exposure of the crowns of medial sagittal portion of the left and the right upper lateral incisors. Grade III: the whole crowns of two upper incisors and one-second of the attached gum of two upper incisors or the crowns and one-second of attached gum of the two upper incisors with over two-third of transverse crowns of the lateral incisors were exposed. Grade IV: the crowns and corresponding attached gum of the upper incisors and over two-third of medial sagittal crowns of the upper lateral incisors were exposed. The relation between the degrees of the whistling deformities and the primary procedures of the bilateral cleft lip or the bilateral cleft lip and cleft palate was analyzed.
RESULTSSixty patients (44.2 percent) had grade I whistling deformities; forty-seven patients (34.5 percent) were Grade II; 16 patients (11.8 percent) were Grade III; 13 cases (9.5 percent) were Grade IV. The results showed that grade I and grade II whistling deformities were obviously more (about 3.7 times) than grade IlI and grade IV whistling deformities.
CONCLUSIONSClassification of whistling deformities provided the objective basis for the selection of operation techniques of cleft lip.
Adolescent ; Adult ; Child ; Cleft Lip ; surgery ; Cleft Palate ; surgery ; Female ; Humans ; Lip ; abnormalities ; Male ; Postoperative Complications ; surgery ; Reconstructive Surgical Procedures ; methods ; Young Adult
10.An application study on assessment for endometrial receptivity by detecting endom- etrial and sub-endometrial perfusion with contrast-enhanced ultrasound
lan Ya ZHANG ; chun Xiu LI ; rong Chang LIU
China Medical Equipment 2017;14(12):7-11
Objective:To discuss the endometrial and sub-endometrial perfusion by using contrast-enhanced ultrasound (CEUS) so as to assess the clinical value of endometrial receptivity.Methods: 86 cases, that were divided into healthy group (49 healthy females) and infertility group (37 patients with infertility), were enrolled in the research. All of cases received detection of color doppler flow imaging (CDFI) and CEUS per vaginam at later period of proliferation, ovulatory period and window phase of implantation, respectively. In these cases, 20 healthy females and 18 patients received endometrial biopsy. The microvessel density (MVD) and time intensity curve (TIC) were analyzed.Results: At the later period of proliferation, the endometrial and sub-endometrial perfusion of the healthy females were significantly more abundant than that of the infertility females as the results of CDFI (x2=4.575,P<0.05). As the results of biopsy for later period of proliferation and ovulatory period, the endometrial MVD of infertility females were significantly lower than that of healthy females (t=7.821, t=8.659,P<0.05). As the results of CEUS for later period of proliferation and ovulatory period, the endometrial and sub-endometrial perfusion peak intensity (Pi) value and area under the curve (AUC) value of healthy females were significantly higher than that of infertility females (t=8.004,t=1.269,t=6.581,t=6.759,P<0.05). Besides, the sub-endometrial Pi were positive correlation with MVD at healthy group and infertility group, respectively.Conclusion:The CEUS can assess the endometrial receptivity through accurately detected endometrial and sub-endometrial perfusion. Therefore, it is worthy to be popularized in clinical practice.