1.Role of new strategy in transmission control of schistosomiasis in Poyang Lake region
feng Yi LI ; qin Chun HANG ; Fei HU ; Min YUAN ; nan Xiao GU ; biao Shang LÜ ; jun Xiao ZENG ; dan Dan LIN
Chinese Journal of Schistosomiasis Control 2017;29(6):689-694,715
Objective To evaluate the role of new strategy in the transmission control of schistosomiasis in Poyang Lake re-gion. Methods The information and epidemic data of schistosomiasis control were collected and analyzed in Poyang Lake re-gion from 2005 to 2016. Results After eleven years of carrying out the new strategy,thirteen counties achieved the objective of transmission control in Poyang Lake region. In 2016,the number of schistosomiasis cases and human infection rate were 10301 and 0.03%,decreased by 89.64%and 99.45%compared with those in 2005,respectively. The number of cattle and schistosome-infected cattle were 68152 and 5,decreased by 50.84%and 99.83%compared with those in 2005,respectively. The average density of Oncomelania hupensis snails was decreased by 61.52%. No schistosome-infected snails were found since 2014. Con-clusion The new strategy accurately locates the key points and targets of schistosomiasis transmission chain ,which has con-trolled the human and animal's fecal eggs from polluting grassland,and cut off the transmission chain,reduced both the infec-tion rates of human and animal and the re-infection risk,and promoted to achieve the target of schistosomiasis transmission con-trol in Poyang Lake region.
2.Recombinant envelope glycoprotein domain III of dengue virus inhibit virus infection.
Peng LU ; Yan WEI ; Shou-Chun CAO ; Jian-Dong LI ; Qin-Zhi LIU ; Quan-Fu ZHANG ; Chuan LI ; Fang MIAO ; Shuo ZHANG ; Xiao-Tong HANG ; Mi-Fang LIANG ; De-Xin LI
Chinese Journal of Experimental and Clinical Virology 2008;22(3):177-179
OBJECTIVETo observe the ability of dengue virus recombinant envelope protein domain expressed in E. coli to inhibit virus infection and induce the neutralizing antibody.
METHODSE III protein of Dengue virus serotypes 1-4 were expressed in E. coli BL21(DE3) then purified. Recombinant proteins were tested to inhibit DV2 from infecting BHK-21 cell. Rabbits were immunized with recombinant proteins to produce anti-E III serum. Antibody titers were determined by neutralizing assay.
RESULTSThe recombinant E III proteins of Dengue virus serotypes 1-4 were expressed in E. coli. They effectively protected BHK cells in culture against DV2 infection. All four type anti-E III sera can neutralize DV2 but their efficacies are different.
CONCLUSIONproteins of dengue virus expressed in E. coli can directly inhibit DV2 infection. Neutralizing antibodies were induced by E III proteins. Both E III protein of dengue virus and the neutralizing antibodies they induced are more efficient in inhibiting homologous dengue serotypes infection than heterologous serotypes.
Animals ; Antibodies, Viral ; immunology ; Cell Line ; Cricetinae ; Dengue ; immunology ; prevention & control ; virology ; Dengue Virus ; chemistry ; genetics ; immunology ; physiology ; Down-Regulation ; Escherichia coli ; genetics ; metabolism ; Humans ; Immunization ; Mesocricetus ; Protein Structure, Tertiary ; Rabbits ; Recombinant Proteins ; chemistry ; genetics ; immunology ; Viral Envelope Proteins ; chemistry ; genetics ; immunology ; Virus Replication
3.An investigation of the sexual physiological and psychological development of 2,770 high school students in Yibin.
Su QIN ; Hou-bin ZHANG ; De-chun GAN ; De-ming RONG ; Sheng-rong LIANG ; Ding-yi WU ; Liang-jun LI ; Min-yong JING ; Ding-ying TU ; He ZHANG ; Yan-ni GUO ; Rui ZHANG ; Zheng-fen ZHU ; Ying LUO ; Yu HANG
National Journal of Andrology 2005;11(1):42-46
OBJECTIVETo investigate the actual condition of the sexual physiological and psychological development of the high school students in Yibin in order to get a reliable basis for sexual education of the teenagers.
METHODSWith a proportion of 1% to the whole, 2,770 students were randomly selected from eight high schools in the urban and rural areas of the city. We devised a questionnaire and asked each student to fill in his or her answers presently.
RESULTSSo far as sexual physiological and psychological development was concerned, the high school students of Yibin were found rather precocious, with very little sexual knowledge and psychological endurance in sexual affairs and a relative lack of sexual education.
CONCLUSIONIt is imperative to extend the scope of puberty sexual education in high schools. Teenagers must be taught different kinds of sexual knowledge at different periods of growth as well as how to avoid sexually transmitted diseases and gestation. The sexual knowledge level of the teachers must also be raised. It is a must to establish service or specialist consultation hot lines about sexual knowledge for teenagers. Parents are expected to change their traditional views and assume an active role in the joint efforts of sexual education for their children.
Adolescent ; Child ; China ; Female ; Humans ; Male ; Menarche ; Psychology, Adolescent ; Psychosexual Development ; Rural Population ; Sexual Development ; Students ; psychology ; Surveys and Questionnaires
4.Trends of soil-transmitted nematode infections in Jiangxi Province
jun Xiao ZENG ; sheng Wei JIANG ; ying Shu XIE ; Jun GE ; jun Zhao LI ; qin Chun HANG ; min Yue LIU ; yu Fang YI ; gen Hong CHEN
Chinese Journal of Schistosomiasis Control 2017;29(6):710-715
Objective To analyze the status and trends of soil-transmitted nematode infections in Jiangxi Province from 1989 to 2014,so as to provide the evidence for generating the strategy of soil-transmitted nematode prevention and control. Methods The data of three epidemiological surveys on human parasitic diseases(in 1989,2002 and 2014)were classified and analyzed. The stool examination by Kato-Katz's thick smear method was adopted for the investigation of soil-transmitted nematode infec-tions. Results The total infection rate of soil-transmitted nematodes decreased by 91.89%from 77.67%in 1989 to 6.30%in 2014,in which the infection rate of Ascaris lumbricoides decreased by 98.78%from 71.11%to 0.87%,the infection rate of Trich-uris trichiura decreased by 96.80%from 29.67%to 0.95%,and the infection rate of hookworm declined by 73.57%from 17.63%to 4.66%. The infection rates of soil-transmitted nematodes in the female were higher than those in the male in three surveys. In different ecological districts,the infection rates of soil-transmitted nematodes in the female were also higher than those in the male,except in Zhe-Min Ecological District in 2002 and 2014. A declined trend of the infection was showed in all age-groups in the three surveys,but it slowed down by the growth of age,i.e.,the reduction rate was 97.03%in the age group of<10 years while 80.62%in the age group of>70 years. In 2014,the number of persons infected with soil-transmitted nematodes occupied 65.4%of the whole number of persons infected with intestinal parasites. Conclusions The mean infection rates of soil-transmit-ted nematodes decrease obviously in human population in different ecological districts,but the soil-transmitted nematodes are still the main species in intestinal parasite infections. The sequence of dominant species changes from A. lumbricoides,hook-worm and T. trichiura in 1989 to hookworm,T. trichiura and A. lumbricoides in 2014. The rural female and elder people are the key population,while hookworm is the key species for the prevention and control of soil-transmitted nematodes.
5.Prevalence, risk factors, clinical course, and outcome of acute kidney injury in Chinese intensive care units: a prospective cohort study.
Ying WEN ; Li JIANG ; Yuan XU ; Chuan-yun QIAN ; Shu-sheng LI ; Tie-he QIN ; Er-zhen CHEN ; Jian-dong LIN ; Yu-hang AI ; Da-wei WU ; Yu-shan WANG ; Ren-hua SUN ; Zhen-jie HU ; Xiang-yuan CAO ; Fa-chun ZHOU ; Zhen-yang HE ; Li-hua ZHOU ; You-zhong AN ; Yan KANG ; Xiao-chun MA ; Xiang-you YU ; Ming-yan ZHAO ; Xiu-ming XI ; Bin DU ; null
Chinese Medical Journal 2013;126(23):4409-4416
BACKGROUNDAcute kidney injury (AKI) has been recognized as a major healthcare problem affecting millions of patients worldwide. However, epidemiologic data concerning AKI in China are still lacking. The objectives of this study were to characterize AKI defined by RIFLE criteria, assess the association with hospital mortality, and evaluate the impact of AKI in the context of other risk factors.
METHODSThis prospective multicenter observational study enrolled 3,063 consecutive patients from 1 July 2009 to 31 August 2009 in 22 ICUs across mainland China. We excluded patients who were admitted for less than 24 hours (n = 1623), younger than 18 years (n = 127), receiving chronic hemodialysis (n = 29), receiving renal transplantation (n = 1) and unknown reasons (n = 28). There were 1255 patients in the final analysis. AKI was diagnosed and classified according to RIFLE criteria.
RESULTSThere were 396 patients (31.6%) who had AKI, with RIFLE maximum class R, I, and F in 126 (10.0%), 91 (7.3%), and 179 (14.3%) patients, respectively. Renal function deteriorated in 206 patients (16.4%). In comparison with non AKI patients, patients in the risk class on ICU admission were more likely to progress to the injury class (odds ratio (OR) 3.564, 95% confidence interval (CI) 1.706 - 7.443, P = 0.001], while patients in the risk class (OR 5.215, 95% CI 2.798-9.719, P < 0.001) and injury class (OR 13.316, 95% CI 7.507-23.622, P < 0.001) had a significantly higher probability of deteriorating into failure class. The adjusted hazard ratios for 90-day mortality were 1.884 for the risk group, 3.401 for the injury group, and 5.306 for the failure group.
CONCLUSIONSThe prevalence of AKI was high among critically ill patients in Chinese ICUs. In comparison with non-AKI patients, patients with RIFLE class R or class I on ICU admission were more susceptibility to progression to class I or class F. The RIFLE criteria were robust and correlated well with clinical deterioration and mortality.
Acute Kidney Injury ; epidemiology ; etiology ; pathology ; Adult ; Aged ; China ; epidemiology ; Female ; Humans ; Intensive Care Units ; statistics & numerical data ; Male ; Middle Aged ; Prospective Studies ; Risk Factors
6.Epidemiological features and changing patterns of intestinal parasitic diseases in Jiangxi Province
Bei-Nan HUANG ; Wei-Sheng JIANG ; Shu-Ying XIE ; Hong-Gen CHEN ; Chun-Qin HANG ; Jun GE ; Zhao-Jun LI ; Wei-Ming LAN ; Xiao-Jun ZENG
Chinese Journal of Schistosomiasis Control 2019;31(3):311-314
Objective To understand the epidemiological features and changing patterns of intestinal parasitic diseases in Jiangxi Province from 1989 to 2014, so as to provide scientific evidence for formulating the preventive and control strategy for intestinal parasitic diseases. Methods The data regarding the status of intestinal parasitic diseases in Jiangxi Province were captured from the 1989 national survey on the distribution of human parasites in China and the 2014 national survey on major human parasitic diseases in China, and the status of human intestinal parasite infections was compared between the two surveys in Jiangxi Province. Results The prevalence rate of human intestinal parasite infections was 79.59% and 9.64% in Jiangxi Province in 1989 and 2014, with a decline rate of 87.89% during the 25-year period (χ2 = 30 870.5, P < 0.01). There were 24 and 20 species of human intestinal parasites detected in Jiangxi Province in 1989 and 2014, respectively, with totally 26 species detected during the two surveys. In Jiangxi Province, the 3 most highly prevalent human intestinal parasites included Ascaris lumbricoides (71.06%), hookworm (17.61%) and Enterobius vermicularis (17.59%) in 1989, and E. vermicularis (13.73%), hookworm (4.66%), whipworm (0.95%) in 2014. A higher rate of human intestinal parasite infections was found in females than in males in both surveys in Jiangxi Province (P < 0.01), and the prevalence of human intestinal parasite infections reduced by 82.50% to 95.31% in different age groups in Jiangsu Province during the 25-year period. Conclusions The prevalence of human intestinal parasite infections shows a remarkable decline tendency in Jiangxi Province, and soil-transmitted nematodes remain the main species of human intestinal parasites in Jiangxi Province.
7.Current status of human hookworm infection in Jiangxi Province in 2014
Shu-Ying XIE ; Zhi-Hong GONG ; Zhe CHEN ; Chun-Qin HANG ; Wei-Ming LAN ; Wei-Sheng JIANG ; Xiao-Jun ZENG
Chinese Journal of Schistosomiasis Control 2018;30(4):446-448
8.Effects of Shenfu Injection () on cerebral metabolism in a porcine model of cardiac arrest.
Qin YIN ; Cai-Jun WU ; Jun YANG ; Chen-Chen HANG ; Chun-Sheng LI
Chinese journal of integrative medicine 2017;23(1):33-39
OBJECTIVETo investigate the effects of Shenfu Injection (, SFI) on cerebral metabolism in a porcine model of cardiac arrest (CA).
METHODSThirty Wuzhishan minipigs were randomly assigned to the control group (n=6), epinephrine group (EP group, n=12) and Sfigroup (n=12). After 8 min of untreated ventricular fifibrillation (VF), pigs in the EP group or Sfigroup were administered with either EP (0.02 mg/kg) or Sfi(1.0 mL/kg), respectively. After successful resuscitation, cerebrospinal fluid (CSF) levels of glucose, pyruvate, lactate, glutamate and glycerol were measured at 1, 6, 12 and 24 h after recover from spontaneous circulation (ROSC). In addition, neurologic defificit score (NDS) was calculated at 24 h after ROSC. Surviving pigs were killed at 24 h after ROSC, and the brain tissue was obtained for ultra-microstructure examination.
RESULTSCompared with the EP group, CSF glucose and pyruvate levels were higher (all P<0.01), and lactate levels were lower in the Sfigroup (P<0.01). Meanwhile, CSF glutamate and glycerol levels in the Sfigroup were lower in comparison to the EP group (all P<0.05). In addition, Sfidecreased NDS at 24 h after ROSC (P<0.01), and alleviated the histopathological damage of the brain.
CONCLUSIONSSficould alleviate brain injury after CA, which may be associated with improving cerebral metabolism.
Animals ; Blood Circulation ; Blood Gas Analysis ; Brain ; drug effects ; metabolism ; ultrastructure ; Cardiopulmonary Resuscitation ; Disease Models, Animal ; Drugs, Chinese Herbal ; administration & dosage ; pharmacology ; therapeutic use ; Heart Arrest ; cerebrospinal fluid ; drug therapy ; physiopathology ; Injections ; Jugular Veins ; drug effects ; metabolism ; Perfusion ; Sus scrofa
9.Investigation of Enterobius vermicularis infection in children in Jiangxi Province in 2014
Wei-Ming LAN ; Hong-Yun LIU ; Zu-Lu GAO ; Jing XU ; Wei-Sheng JIANG ; Cheng-Jian HUANG ; Shu-Ying XIE ; Chun-Qin HANG ; Xiao-Jun ZENG
Chinese Journal of Schistosomiasis Control 2018;30(4):449-451
10.Textual research on classical famous prescription Dajianzhong Decoction.
Ming-Xi LIU ; Ning ZHANG ; Qi GAO ; Zi-Hang XU ; Bing WANG ; Guo-Qin ZHU ; Chun-Pu ZOU
China Journal of Chinese Materia Medica 2022;47(15):4025-4032
The classical famous prescription Dajianzhong Decoction is recorded in Synopsis of the Golden Chamber written by Zhang Zhongjing in the Eastern Han Dynasty. It has a long history and definite clinical effects, while this prescription has not been manufactured into Chinese patent medicine preparation. We collected many ancient books of traditional Chinese medicine(TCM) by using the method of bibliometrics and got 211 valid data terms which involved 67 ancient books. The history, main treated syndromes, formulation principle, origins and processiong of medicinal materials, and decoction method of Dajianzhong Decoction were analyzed. Despite the different views of various generations of medical experts toward the composition of this prescription, the compatibility ratio of Ginseng Radix et Rhizoma to Zingiberis Rhizoma Recens is constant. Furthermore, we explored the origins of synonyms of Dajianzhong Decoction. On the basis of this study, we hope to gain an insight into the research and development of the compound preparations of Dajianzhong Decoction and provide reference for the heritage and innovation of other classical prescriptions.
Drugs, Chinese Herbal
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Medicine, Chinese Traditional
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Prescriptions
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Rhizome