1.Study of new idea of subject integration of pathobiology
Chun YANG ; Yonglin HE ; Lei XU
Chinese Journal of Medical Education Research 2006;0(12):-
This article aims at exploring ways of integrating subject of pathobiology under the guidance of scientific outlook on development and improving and enriching pathobiology inte-gration and construction through curriculum systems recombination and integration,teaching con-tents optimization to reflect the latest research progress,network education platform establish-ment,comprehensive and exploratory laboratory course teaching system construction,new syl-labus and teaching material making up.
3.Extraventricular neurocytoma of spinal cord: report of a case.
Chun-nian WANG ; Xiang-lei HE ; Zhao-xia XIA
Chinese Journal of Pathology 2012;41(10):702-703
Antigens, Nuclear
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metabolism
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Cordotomy
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methods
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Diagnosis, Differential
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Ependymoma
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metabolism
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pathology
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Follow-Up Studies
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Humans
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Male
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Middle Aged
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Nerve Tissue Proteins
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metabolism
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Neurocytoma
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metabolism
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pathology
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surgery
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Oligodendroglioma
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S100 Proteins
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metabolism
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Spinal Cord Neoplasms
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metabolism
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pathology
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surgery
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Synaptophysin
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metabolism
4.Clear cell papillary cystadenoma of left mesosalpinx associated with von Hippel-Lindau disease: report of a case.
Xiang-lei HE ; Chun-nian WANG ; Jian-min ZHANG
Chinese Journal of Pathology 2009;38(5):349-350
Adenocarcinoma, Clear Cell
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complications
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metabolism
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pathology
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surgery
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Adenoma
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pathology
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Adnexal Diseases
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pathology
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Adult
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Carcinoma, Renal Cell
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pathology
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secondary
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Cystadenoma, Papillary
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complications
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metabolism
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pathology
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surgery
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Diagnosis, Differential
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Fallopian Tube Neoplasms
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complications
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metabolism
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pathology
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surgery
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Female
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Follow-Up Studies
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Humans
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Keratin-7
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metabolism
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Kidney Neoplasms
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pathology
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secondary
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Mucin-1
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metabolism
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von Hippel-Lindau Disease
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complications
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metabolism
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pathology
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surgery
5.Construction and practice of Pathogen biology quality courses
Chun YANG ; Yonglin HE ; Lei XU ; Jing ZHANG
Chinese Journal of Medical Education Research 2012;11(5):490-493
Pathogen biology is a main course of curricula in medical university.In developing quality courses,we optimized Pathogen biology course content,created the PBL teaching mode suitable for this course,set up network teaching platform,enhanced teachers' qualification,constructed comprehensive and exploratory experiment teaching system,wrote new teaching syllabus and other measures,made the Pathogen biology course construction more reasonable and perfect.
6.Reforming of optimizing microbiology curriculum systems to different specialties
Chun YANG ; Yonglin HE ; Lei XU ; Zhibang YANG
Chinese Journal of Medical Education Research 2005;0(06):-
To fully incarnate"specialization"peculiarities of microbiology teaching courses by means of optimizing microbiology teaching contents and curriculum systems,and making up a new syllabus suitable to different specialties will lay a very solid foundation for cultivating medical talents with specialty traits.
7.Littoral cell angioma of the spleen in a patient with chronic hepatitis B and hepatocellular carcinoma.
Chun-Nian WANG ; Xiang-Lei HE ; Hong-Bin ZHANG ; Hua-Xin DING
Chinese Journal of Pathology 2007;36(12):858-859
Carcinoma, Hepatocellular
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complications
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Hemangioma
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complications
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diagnosis
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immunology
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pathology
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Hepatitis B, Chronic
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complications
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Hepatocytes
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cytology
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pathology
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Humans
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Liver Cirrhosis
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complications
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Liver Neoplasms
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complications
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Male
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Middle Aged
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Platelet Endothelial Cell Adhesion Molecule-1
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immunology
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Spleen
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immunology
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pathology
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Tomography, X-Ray Computed
8.The clinical significance of combined measurement of anti-saccharomyces cerevisia antibody and antiperinuclear neutrophil cytoplasmic antibody in inflammatory bowel disease
Shulan ZHANG ; Yongzhe LI ; Lei LI ; Dawei TONG ; Zhaojun HU ; Chun HE ; Ji LI
Chinese Journal of Laboratory Medicine 2008;31(10):1142-1146
Objective To evaluate the clinical significance of combined measurement of antiperinuclear neutrophil cytoplasmic antibody(ANCA)and anti-saccharomyees cerevisia antibody(ASCA)for the diagnosis of inflammatory bowel disease(IBD)patients and difierentiation of Crohn's disease(CD)with ulcerative colitis(UC).Methods A total of 159 patients with IBD(97 UC,62 CD),167 patients with other non-IBD gastrointestinal conditions(NIBDC)and 25 healthy controls(HC)were recruited in our research.ASCA and ANCA were detected by enzyme-linked immunosorbent assay(ELISA)and indirect immunofluorescence assay.respectively.Results The prevalence of ASCA-IsA or IgG in CD group,UC group,NIBDC and HC were43.5%,14.4%,29.3%and 0,respectively.The prevalence of ASCA-IgA or IgG in CD group were higher than those in other groups(X2=16.76 or 4.12,P<0.01 or<0.05).The prevalence of ANCA in CD group.UC group,NIBDC and HC were 8.1%,56.7%,4.8%and 0,respectively.The prevalence of AMA in UC group were much higher than those in other groups(X2=38.08 or 90.47,P<0.01).The sensitivity specificity and positive predictive value(PPV)in ASCA+/ANCA-were 40.3%.93.8% and 80.6%,respectively,and in ANCA+/ASCA-were 48.5%,98.4% and 97.9%,respectively.Condusions ASCA or ANCA testing alone are not sensitive enoulgh for diagnosing CD and UC,but their combination asses are specific for differential diagnosis between CD and UC.Combined testing of ASCA-IgA with IgG can improve the sensitivity in screening CD patients.The ASCA positive pattern in Chinese CD group are correlated with surgery.
9.Progress in the biomarker discovery for drug-induced liver injury.
Lei-yan HE ; Yao-xue GUO ; Chun LI ; Ye DENG ; Qi-zhi ZHANG ; Wen-xing PENG
Acta Pharmaceutica Sinica 2015;50(8):959-965
The leading cause of drug withdrawal from market and clinical trials failure is drug-induced liver injury (DILI). Varying clinical, histological and laboratory features of DILI, as well as undefined underlying mechanisms, hinder patients to be diagnosed in the early-stage of the disease and receive effective treatments. Conventional indicators, like serum transaminases and bilirubin, have inevitable limitations referring to sensitive prediction and specific detection of DILI. In order to reduce the occurrence of DILI, researchers have attempted to discover potential biomarkers with higher specificity and sensitivity from blood and urine in recent years. This article aims to review recent advances in biomarkers of DILI.
Biomarkers
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blood
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urine
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Chemical and Drug Induced Liver Injury
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diagnosis
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Humans
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Sensitivity and Specificity
10.Recent Progress on Plant Bioreactor Expressing Pharmaceutical Proteins
Xiao-Chun DU ; Zheng-Quan HE ; Lei CHEN ; Ye YANG ; Wei YAO ;
China Biotechnology 2006;0(09):-
Plant bioreactor called mocular farming has enormous potential to produce recombinant protein infinitely. Products expressed in plants has nature physico-chemical property and bioactivity. Plant bioreactor could be an safe, economic and convenient production system which has been widely applied in industries and agriculture, especially in the life science and pharmaceutical industry. The application of recombinant transgenic plant in the production of vaccines, antibodies and pharmaceutical proteins has become a hot point in the plant genetic engineering both at home and broad. However, there are some limiting factors of application such as yield, downstream processing and so on. The advantages and research progress for the mocular farming of pharmaceutical proteins recent three years was discussed, focusing on the existing problems and new strategies in this area.