1.Study of new idea of subject integration of pathobiology
Chun YANG ; Yonglin HE ; Lei XU
Chinese Journal of Medical Education Research 2006;0(12):-
This article aims at exploring ways of integrating subject of pathobiology under the guidance of scientific outlook on development and improving and enriching pathobiology inte-gration and construction through curriculum systems recombination and integration,teaching con-tents optimization to reflect the latest research progress,network education platform establish-ment,comprehensive and exploratory laboratory course teaching system construction,new syl-labus and teaching material making up.
2.Extraventricular neurocytoma of spinal cord: report of a case.
Chun-nian WANG ; Xiang-lei HE ; Zhao-xia XIA
Chinese Journal of Pathology 2012;41(10):702-703
Antigens, Nuclear
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metabolism
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Cordotomy
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methods
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Diagnosis, Differential
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Ependymoma
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metabolism
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pathology
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Follow-Up Studies
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Humans
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Male
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Middle Aged
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Nerve Tissue Proteins
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metabolism
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Neurocytoma
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metabolism
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pathology
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surgery
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Oligodendroglioma
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S100 Proteins
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metabolism
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Spinal Cord Neoplasms
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metabolism
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pathology
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surgery
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Synaptophysin
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metabolism
3.Clear cell papillary cystadenoma of left mesosalpinx associated with von Hippel-Lindau disease: report of a case.
Xiang-lei HE ; Chun-nian WANG ; Jian-min ZHANG
Chinese Journal of Pathology 2009;38(5):349-350
Adenocarcinoma, Clear Cell
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complications
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metabolism
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pathology
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surgery
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Adenoma
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pathology
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Adnexal Diseases
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pathology
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Adult
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Carcinoma, Renal Cell
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pathology
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secondary
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Cystadenoma, Papillary
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complications
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metabolism
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pathology
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surgery
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Diagnosis, Differential
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Fallopian Tube Neoplasms
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complications
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metabolism
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pathology
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surgery
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Female
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Follow-Up Studies
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Humans
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Keratin-7
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metabolism
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Kidney Neoplasms
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pathology
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secondary
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Mucin-1
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metabolism
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von Hippel-Lindau Disease
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complications
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metabolism
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pathology
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surgery
5.Construction and practice of Pathogen biology quality courses
Chun YANG ; Yonglin HE ; Lei XU ; Jing ZHANG
Chinese Journal of Medical Education Research 2012;11(5):490-493
Pathogen biology is a main course of curricula in medical university.In developing quality courses,we optimized Pathogen biology course content,created the PBL teaching mode suitable for this course,set up network teaching platform,enhanced teachers' qualification,constructed comprehensive and exploratory experiment teaching system,wrote new teaching syllabus and other measures,made the Pathogen biology course construction more reasonable and perfect.
6.Reforming of optimizing microbiology curriculum systems to different specialties
Chun YANG ; Yonglin HE ; Lei XU ; Zhibang YANG
Chinese Journal of Medical Education Research 2005;0(06):-
To fully incarnate"specialization"peculiarities of microbiology teaching courses by means of optimizing microbiology teaching contents and curriculum systems,and making up a new syllabus suitable to different specialties will lay a very solid foundation for cultivating medical talents with specialty traits.
7.Progress in the biomarker discovery for drug-induced liver injury.
Lei-yan HE ; Yao-xue GUO ; Chun LI ; Ye DENG ; Qi-zhi ZHANG ; Wen-xing PENG
Acta Pharmaceutica Sinica 2015;50(8):959-965
The leading cause of drug withdrawal from market and clinical trials failure is drug-induced liver injury (DILI). Varying clinical, histological and laboratory features of DILI, as well as undefined underlying mechanisms, hinder patients to be diagnosed in the early-stage of the disease and receive effective treatments. Conventional indicators, like serum transaminases and bilirubin, have inevitable limitations referring to sensitive prediction and specific detection of DILI. In order to reduce the occurrence of DILI, researchers have attempted to discover potential biomarkers with higher specificity and sensitivity from blood and urine in recent years. This article aims to review recent advances in biomarkers of DILI.
Biomarkers
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blood
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urine
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Chemical and Drug Induced Liver Injury
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diagnosis
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Humans
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Sensitivity and Specificity
8.Littoral cell angioma of the spleen in a patient with chronic hepatitis B and hepatocellular carcinoma.
Chun-Nian WANG ; Xiang-Lei HE ; Hong-Bin ZHANG ; Hua-Xin DING
Chinese Journal of Pathology 2007;36(12):858-859
Carcinoma, Hepatocellular
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complications
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Hemangioma
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complications
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diagnosis
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immunology
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pathology
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Hepatitis B, Chronic
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complications
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Hepatocytes
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cytology
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pathology
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Humans
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Liver Cirrhosis
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complications
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Liver Neoplasms
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complications
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Male
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Middle Aged
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Platelet Endothelial Cell Adhesion Molecule-1
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immunology
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Spleen
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immunology
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pathology
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Tomography, X-Ray Computed
9.Recent Progress on Plant Bioreactor Expressing Pharmaceutical Proteins
Xiao-Chun DU ; Zheng-Quan HE ; Lei CHEN ; Ye YANG ; Wei YAO ;
China Biotechnology 2006;0(09):-
Plant bioreactor called mocular farming has enormous potential to produce recombinant protein infinitely. Products expressed in plants has nature physico-chemical property and bioactivity. Plant bioreactor could be an safe, economic and convenient production system which has been widely applied in industries and agriculture, especially in the life science and pharmaceutical industry. The application of recombinant transgenic plant in the production of vaccines, antibodies and pharmaceutical proteins has become a hot point in the plant genetic engineering both at home and broad. However, there are some limiting factors of application such as yield, downstream processing and so on. The advantages and research progress for the mocular farming of pharmaceutical proteins recent three years was discussed, focusing on the existing problems and new strategies in this area.
10.An observation on clinical effectiveness of early rehabilitative training program in patients with acute myocardial infarction
Lei ZHOU ; Guo-Ming WEN ; Xia HUANG ; Wan-Hong HE ; Chun-Rong ZHANG ; Xiao-Lan GONG ;
Chinese Journal of General Practitioners 2005;0(08):-
Objective To investigate the effects of early rehabilitative training program on patients with acute myocardial infarction(AMI).Methods One hundred and twenty-two patients with AMI were randomly divided into early rehabilitation group(n=62)and control group(n=60).In addition to routine treatment,patients in rehabilitation group received early rehabilitative training mainly by walking exercise for two weeks.Results There were no significant differences in ventricular arrhythmia(Lown≥Ⅲ), extension of infarction and heart rate variability(HRV)between the two groups(P>0.05).Forty of 62 patients(64.5%)in rehabilitation group had their left ventricular ejection fraction(LVEF)more than or equal to 50% in the 3~(rd)~4~(th)week after admission,significantly higher than that in control group(45.0%, 27/60 ;P<0.01 ).By the end of the 4~(th)week after admission,25.8% of the patients in rehabilitation group showed positive in treadmill test,significantly lower than that in control group(38.3%,P<0.01). Occurrence of angina pectoris and reinfarction and fatality in rehabilitation group were significantly lower than those in control group(P<0.05)during their hospitalization and follow-up period.Patients in rehabilitation group stayed at hospital for(16?3)days in average,significantly less than that in control group[(27?4) days],with statistically significant difference(P<0.05).Conclusion Early rehabilitative training for patients with uncomplicated AMI is not only safe and feasible,but also useful in improvement for their prognosis and quality of life.