Acupuncture Therapy ; instrumentation ; methods ; Adult ; Aged ; Female ; Hot Temperature ; Humans ; Male ; Middle Aged ; Needles ; Spondylosis ; therapy ; Treatment Outcome ; Young Adult

Anti-Infective Agents ; administration & dosage ; Clinical Competence ; Hematologic Diseases ; Hospitals, Special ; manpower ; Humans ; Medical Staff, Hospital

Objective To evaluate the biomechanical characteristics of the long U-shaped hollow pedicle screw system for percutaneous fixation of thoracolumbar fractures.Methods Models of vertebral compression fracture were created by flexion in 8 fresh cadaveric samples of thoracolumbar spine.The models were divided into 2 equal groups according to the fixation system applied.In group A conventional pedicle screws were used while in group B long U-shaped hollow pedicle screws were used.The yield compressive strength,axial compression stiffness,bending stiffness,torque and torsional stiffness of all the fixated spines in the 2 groups were tested by the bio-mechanical electrical measurement and compared as well.Results The conventional pedicle screws and long U-shaped hollow pedicle screws showed no significant differences regarding yield compressive strength (3450.02 ± 110.03 MPa vs.3430.04 ± 102.12 MPa),axial compressionstiffness (407.52 ± 33.02 N/mm vs.395.04 ± 26.46 N/mm),bending stiffness (305.14 ± 26.53 N · cm/Degvs.295.12±23.80 N · cm/Deg),torque (6.45±0.25 N · m vs.6.25±0.21 N · m) or torsional stiffness (0.54±0.04N·cm/Degvs.0.52±0.03N·cm/Deg) (P＞ 0.05).Conclusion The long U-shaped hollow pedicle screw system can satisfy the biomechanical requirements for fixation of thoracolumbar fractures and can function as well as the conventional pedicle screw system.

Total glucosides of paeony (TGP)is used to treat rheumatoid arthritis(RA)as the first immunoregulatory drug in clinic.The efficacy of TGP in treating RA patients is definite, which is accompanied with mild adverse reaction and slow effects simultaneously.Paeoniflorin (Pae ),the main constituents of TGP,has a bioavailability of 3% ~4%,which may be served as the main reason for its slow effects.Therefore,in this paper,the pharmacokinetics of Pae as well as its influencing factors were re-viewed on basis of pulished papers.In addition,some problems about Pae were also discussed.

Objective To survey the application of diagnosis and implementation of treatment guidelines of cerebrovascular disease( CAD)combined community acquired pneumonia( CAP)in the community of Shenyang. Methods Randomly chose 7 hospitals in different levels in districts and counties of Shenyang,and made a retrospective survey on the treatments of CAD combined CAP from Oct. 2009 to Jun. 2012 to clear the implementation. Meanwhile,the collected cases were divided into in compliance with guidelines group and non compliance with guidelines group. The information including clinical stable time,length of hospital stay,efficient treatment,empiric therapy and prognosis with the help of guidelines were collected. Results Four hundred and eighty-eight cases were qualified from collected 532 cases,in which,38. 5% initial diagnosis and treatment was accord with the guidelines formulated by the Respiratory Branch of Chinese Medical Association. The efficiency of initial empirical treatment was 84. 5%. The clinical stable time in compliance with guidelines group was (5. 00 ± 0. 27)d,better than that in non compliance with guidelines group((8. 00 ± 0. 45)d;P=0. 021). The length of hospital stay was(11. 00 ± 0. 25)d in compliance with guidelines group,significantly less than that in non compliance with guidelines group(( 14. 00 ± 0. 53 ) d;P =0. 015 ). The effective rate of patients with respiratory failure in compliance with guidelines group was 90. 9%,higher than non compliance with guidelines group(58. 6%),and the difference was significant(P=0. 026),while there were no significant differences in terms of gender,heart and lung diseases. Conclusion There is the smaller patient proportion that diagnosed and cured in accordance with the guidelines formulated by the Respiratory Branch of Chinese Medical Association. It is no distinctive difference for the efficient treatment of guidelines. But selected antibiotic application according to the guidelines can improve the clinical stable time and hospital stay of CAD combined CAP,as well as reduce invalid cases and reduce the mortality rate. The guidelines need to be further extended.

Magnetic Resonance Imaging (MRI) can form a three-dimensional positioning anatomical imaging.By comparing the tumor volume and signal intensity changes,there is great value of MRI in the assessment of the efficacy of cervical cancer.With the development of imaging,magnetic resonance diffusion weighted imaging (DWI),magnetic resonance spectroscopy (MRS) can provide qualitative and quantitative information of the cellular level,which reflects changes in the treatment of tumor cells.Magnetic resonance imaging can predict early locally advanced cervical cancer neoadjuvant chemotherapy,thus providing an important basis for individualized treatment of patients.

Objective To investigate distributions and drug resistance of pathogens in cirrhotic ascites comphcated with spontaneous bacterial peritonitis (SBP). Methods Results of bacterial culture and drug sensitivity tests of 117 aacitie specimens from cirrhotic patients with SBP were analyzed retrospectively. Results From the 117 ascitie specimens, 117 bacterial strains were isolated, among which 71 (60.68%)were gram-negative bacteria, 45 (38.46%) were gram-positive bacteria. The isolated strains were highly resistant to antibacterial agents, especially for Escherchia coli and Staphylococcu, the resistances to most antibiotics were above 60%. Conclusions High drug resistances were common for pathogenic bacteria in aacites of liver cirrhosis patients complicated with SBP.

Objective: To investigate the relationship between attributional style and personality. Methods: We measured undergraduates with Attributional Style Questionnaire(ASQ)and Sixteen Personality Factor Questionnaire(16-PF).Results: Students with high-sensitivity, high-insecurity, high-tension, anxiety, not tough poise and low marks in Mental Health are apt to have negative attributional style. These personalities are the nuclear personalities of negative attributional style. Students with high-suspiciousness, high-insecurity,anxiety and low marks in Academic Achievement and Adjustment are apt to attribute fatefully. Conclusion: The nuclear personalities for negative attributional style are high-sensitivity, high-insecurity, high-tension, anxiety, not tough poise and low marks in Mental Health.

AIM To study the hepato-protection of indole-3-carbinol (I3C), one of glucosinolate compounds in cruciferous vegetables, on ethanol-induced hepatotoxicity. METHODS Ethanol 50 mmol?L -1 was used to induce hepatotoxicity in precision liver-cut slices of rats. The release of glutamic pyruvic transaminase(GTP), glutamic oxaloacetic transaminase (GOT), lactate dehydrogenase (LDH) and glutathione S-transferase (GST) into culture medium, and aniline hydroxylase (ANH) and alcohol dehydrogenase (ADH) in cytosol of hepatocytes in the precision liver-cut were measured with different doses of I3C. The histopathological observation of liver slices was also done to evaluate the effect of I3C. RESULTS The release of GTP, GOT, GST and LDH in the medium increased significantly when the slices were treated with 50 mmol?L -1 ethanol for 4 h. I3C at concentrations of 100～400 ?mol?L -1 effectively reduced the release of GTP, GOT, GST and LDH in the medium of ethanol-treated slices. Meanwhile, the activities of cytosol ANH and ADH decreased to the normal levels. The histopathological changes of liver slices induced by ethanol were lessened by I3C treatment. CONCLUSION I3C can markedly protect rat liver slices from ethanol-induced hepatotoxicity, which partly results from the change of ethanol metabolism in liver.

Objective To study the changes in the expression of GABA and its receptors in the dorsal horn of rat spinal cord induced by hind paw formalin injection. Methods Twelve healthy male SD rats weighing 300-325 g were randomly divided into two groups: (A) control group (n=6) and (B) peripheral inflammatory hyperalgesia group in which 5% formalin 50?l was injected subcutaneously into the plantar region of right hind paw to produce persistent pain(n=6). The animals were killed 24h after formalin injection. L_(4-6) segment of the spinal cord was removed. The number of GABA immuno-reactive cells was examined by immuno-cytochemistry technique and the exprpession of GABA_(A?3) and GABA_(B1) receptor mRNA in the spinal dorsal horn were determined by in situ hybridization. Results In control group(A), GABA immuno-reactive cells and GABA_(A?3) and GABA_(B1) receptor mRNA were observed throughout the lumbar spinal dorsal horn. The density of GABA immuno-reactive cells and GABA_(B1) receptor mRNA was highest in the superficial laminae Ⅰ-Ⅲ; while the GABA_(A?3) receptor mRNA was evenly distributed in the spinal dorsal horn. In group B, 24h after formalin injection there was a significant increase in the GABA immuno-reactive cells in the ipsilateral spinal dorsal horn. The expression of GABA_(A?3) and GABA_(B1) receptor mRNA were significantly increased in bilateral dorsal horn compared to group A. The three parameters were positively correlated and their locations in the spinal dorsal horn were not significantly different from those in group A. Conchusion GABA and its receptors may play an important role in nociceptive modulation.