Adolescent ; Child ; Diabetes Mellitus, Type 1 ; prevention & control ; therapy ; Diabetes Mellitus, Type 2 ; prevention & control ; therapy ; Humans

Silicosis ; diagnosis ; Terminology as Topic

Objective To compare the effect of different methods of anesthesia on cerebral autoregulation in patients undergoing neurosurgery.Methods Sixty-nine ASA Ⅱ orⅢ patients with brain tumor, aged 23-62 yr, scheduled for neurosurgery under general anesthesia, were randomly divided into 3 groups ( n = 23 each) : propofol-remifentanil group (group PR), sevoflurane-remifentanil group (group SR) and propofol-sevoflurane-remifentanil group (group PSR) . Anesthesia was induced with target-controlled infusion (TCI) of propofol (target plasma concentration3 μg/ml, PR and PSR groups) or inhalation of 8% sevoflurane (group SR) and iv injection of remifentanil 1 mg/kg and atracurium 0.5 mg/kg. The patients were mechanically ventilated after tracheal intubation. PETCO2 was maintained at 32-35 mm Hg. Anesthesia was maintained with TCI of propofol (target plasma concentration 2.0-3.5 μg/ml) in group PR, with inhalation of 1.5%-2.5% sevoflurane in group SR, with TCI of propofol (target plasma concentration 1.5-3.0 μg/ml) and inhalation of 1% sevoflurane in group PSR, and with TCI of remifentanil (target plasma concentration 2.0-4.5 ng/ml) and iv infusion of atracurium at 6 μg · kg-1 · min-1 in all groups. Auditory evoked potential index was maintained between 40-45. The middle cerebral artery time-average peak flow velocity was recorded before induction (baseline) , immediately after intubation, immediately before craniotomy and at the beginning of skin suture. The unilateral carotid artery was compressed for 7 s at the corresponding time points mentioned above. The transient hyperemic response ratio (THRR) was calculated to reflect cerebral autoregulation. Results Compared with the baseline value at T0, THRR was significantly increased at T2in group PR and decreased at T2,3 in group SR (P <0.05) ,while no significant change was found in THRR at T1-3in group PSR (P >0.05). The THRR was significantly lower in SR and PSR groups than in group PR, and higher in group PSR than in group SR ( P < 0.05). Conclusion Propofol-remifentanil anesthesia can improve cerebral autoregulation, sevoflurane-remifentanil anesthesia can reduce cerebral autoregulation, and propofol-sevofluraneremifentanil anesthesia exerts no effect on cerebral autoregulation in patients undergoing neurosurgery.

Objective To improve the organization and training of clinical teaching so as to accomplish teaching task well.Methods Based on the experience of teaching in many years,network stream medium is utilized in design.Results An operation live video system for demonstration teaching was developed.Conclusion Based on HIS and PACS,hospital network demonstration teaching system is a multimedia network video system,which takes full advantage of network communication technology,video frequency stream and sound stream technology.The system is a new application of information-based medical treatment developed from Wide Band.

Objective To explore the relationship between obesity levels and adipocytokines like leptin,adiponectin and resistin in children.Methods One hundred and ten patients aged 2-6 years with simple obesity were selected into obesity group,which included 40 cases of slight obesity (slight obesity group),40 cases of medium obesity (medium obesity group) and 30 cases of severe obesity (severe obesity group).Forty cases of healthy children with normal bodyweight were included in control group.Their serum leptin,adiponectin and resistin levels were tested and compared.Results Serum leptin and resistin levels in obesity group were remarkably higher than those in control group (P < 0.01),whereas adiponectin level was much lower than that in control group (P< 0.01).Serum leptin and resistin levels in medium obesity group were remarkably higher than those in slight obesity group [(14.3 ±1.9) μg/L vs (7.8 ± 1.5)μg/L and (14.6±2.2) μg/Lvs (13.1 ±3.0) μg/L](P< 0.01),whereas adiponectin level was much lower than that in slight obesity group[(6.7 ± 3.0) mg/L vs (9.1 ± 3.5) mg/L](P< 0.01).Serum leptin and resistin levels in severe obesity group [(20.4 ±4.7),(18.3 ±3.2) μg/L]were remarkably higher than those in medium obesity group(P< 0.01),whereas adiponectin level [(5.1 ± 1.2) mg/L]was much lower than that in medium obesity group (P< 0.01).Conclusion The levels of adipocytokines are closely correlated with obesity level in children,especially for abdominal obesity.

Abstract? AlM: To investigate the application effect of recombinant human epidermal growth factor derivative eye drops ( Jinyinshu) in treatment of dry eye.?METHODS:Sixty cases ( 87 eyes ) of dry eye patients were randomly divided into control group and observation group, 42 eyes and 45 eyes respectively. The control group received Chondroitin sulfate eye drops treatment, and the observation group were used for treatment of Jinyinshu. The changes of clinical efficacy, correlation index (symptom score, BUT, S l t, FL) before and after treatment, quality of life after treatment and the incidence of adverse reactions were compared.? RESULTS: ln the control group, the total clinical effective rate was 71%, which was significantly lower than that in the observation group ( 91%) , the difference was statistically significant ( P<0. 05 ); There were statistical differences of symptom scores, BUT, S▏t and FL level of the two groups before and after treatment (P<0. 05), and there were statistical differences of the above indexes after treatment between the two groups ( P<0. 05 ); The quality of life score was 142. 16 ± 10. 32 of the observation group after treatment, which was significantly higher than that in the control group after treatment (115. 24±7. 34), the difference was statistically significant (P<0. 05); The incidence of adverse reaction of the control group was 13%, 10% in the observation group, and there were no statistical differences (P>0. 05).?CONCLUSlON:Jinyinshu is significantly effective in the treatment of dry eye, and its clinical efficacy is better than chondroitin sulfate.

Female ; Humans ; Infant ; Nasopharyngeal Neoplasms ; pathology ; Teratoma ; pathology

Cardiovascular Diseases ; Humans ; Membrane Proteins ; Neoplasm Proteins ; Stromal Interaction Molecule 1

Objective: To observe the expression of local angiotensin-converting enzyme 2 (ACE-2) in rat liver and its relationship with preservation injury (PI) after transplantation, so as to determine the possible role of local renin-angiotensin system (RAS) in PI caused by the cold-preservation in liver transplantation. Methods: The donor liver grafts were divided into cold preservation (CP) and non-cold preservation (NCP) groups; we also included a sham operation group without transplantation. The mRNA and protein levels of ACE-2 in the transplanted livers were detected by quantitative real-time PCR and Western blotting assay, respectively. The location of ACE-2 protein and pimonidazole in liver was detected by immunohistochemistry. Furthermore, histological evaluation was applied to verify the extent of liver damage. Results: Histological injuries of different degrees existed after liver transplantation; the injury was more obvious in the CP group. Compared with the sham operation group, the mRNA and protein expression of ACE-2 was significantly increased after liver transplantation (P<0.05 or P<0.01), and the expression of the CP group was significantly higher than that of the NCP group (P<0.05). Pimonidazole staining was positive around the hepatic veins in the transplantation groups, and the intensity of staining was positively correlated with the expression of ACE-2 mRNA (r=0. 78, P<0.001). Conclusion: It is indicated that ACE-2 expression is closely associated with tissue hypoxia during cold preservation-induced PI, and local RAS may play an important role in PI during liver transplantation.

Hepatic ischemia reperfusion injury (IRI) is a critical problem of liver surgery, especially when comes to liver transplantation. Presently, there are no effective measures for diagnosis, prevention and therapy of IRI, as the mechanisms of IRI still remain unclear. This review summarizes several new hepatic ischemia-reperfusion markers related to cell signal transduction pathway, including transcription factor STAT, HIF-1 and PPARs, transmission factor MAPK, membrane receptor TLR4 and PARs, and iNOS. Animal studies have indicated that IRI was ameliorated by activating or blockading these markers, which might serve as targets for diagnosis, prevention and therapy of IRI.