2.Progress in study of antioxidant effects of Coptis chinensis and its major contributions to diabetes treatment/therapy.
China Journal of Chinese Materia Medica 2015;40(12):2285-2288
Coptis chinensis, a traditional Chinese medicine, has been found to have multiple pharmacological effects recently. Some research showed that C. chinensis has antioxidant effects, including scavenging oxygen free radicals, alleviating lipid peroxidation, enhancing activity of antioxidant enzymes, et al. C. chinensis may inhibit several classical pathological pathways in diabetes. C. chinensis is a potential medicine to prevent and treat diabetes mellitus and its complications. This review focuses on the recent research progress in the study of antioxidant effects of C. chinensis and its major contributions to diabetes treatment/therapy.
Animals
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Antioxidants
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administration & dosage
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Coptis
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chemistry
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Diabetes Mellitus
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drug therapy
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metabolism
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Drugs, Chinese Herbal
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administration & dosage
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Humans
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Lipid Peroxidation
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drug effects
3.Study on the pathogenesis mechanism of diabetic neuropathy and intervention on it by Chinese and Western medicine.
Chinese Journal of Integrated Traditional and Western Medicine 2004;24(6):570-573
Aldehyde Reductase
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metabolism
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Animals
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Autoantibodies
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metabolism
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Diabetic Neuropathies
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drug therapy
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etiology
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metabolism
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Drugs, Chinese Herbal
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therapeutic use
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Humans
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Nerve Growth Factor
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metabolism
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Nitric Oxide
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metabolism
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Phospholipids
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immunology
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Phytotherapy
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Somatomedins
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metabolism
5.A case of pulmonary artery ectasia misdiagnosed as stage III coal worker's pneumoconiosis.
Liang CHEN ; Yi LI ; Chun-xiao YU
Chinese Journal of Industrial Hygiene and Occupational Diseases 2007;25(9):576-557
Anthracosis
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diagnosis
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Diagnostic Errors
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Humans
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Lung Diseases
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diagnosis
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Male
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Middle Aged
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Pulmonary Artery
8.Role of Nrf2 in neurodegenerative diseases and recent progress of its activators.
Chun-yang ZHAO ; Xiao-liang WANG ; Ying PENG
Acta Pharmaceutica Sinica 2015;50(4):375-384
The nuclear factor erythroid 2 related factor 2 (Nrf2) is a key protein of endogenous antioxidant defense systems in the body. In response to oxidative stress, Nrf2 translocates to nucleus and binds to antioxidant response elements (ARE), regulating the expression of a large amounts of antioxidant genes and maintaining a proper redox balance. The pathological processes of neurodegenerative diseases are associated with generation of reactive oxygen species, which cause oxidative stress. Oxidative stress plays a cardinal role in the onset and progression of neurodegenerative diseases. Nrf2-inducer compounds can reduce oxidant stress and have shown therapeutic efficacy in many neurodegenerative disease models. How to activate the Nrf2 signaling pathway effectively has been received much attention. Here we provided an overview of specific mechanism of Nrf2-ARE pathway and the protective effects of Nrf2 in different neurodegenerative diseases, and summarized the Nrf2 activators recently in preclinical study.
Antioxidants
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physiology
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Humans
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NF-E2-Related Factor 2
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physiology
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Neurodegenerative Diseases
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metabolism
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Oxidative Stress
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Reactive Oxygen Species
;
metabolism
;
Signal Transduction
10.Auto-bone marrow mononuclear cells transplantation accelerates reendothelialization and inhibits neointima formation in vein grafts
Yan GAO ; Zonggui WU ; Chun LIANG ; Haijun XIAO
Academic Journal of Second Military Medical University 1982;0(01):-
Objective:To assess the effect of auto-bone marrow mononuclear cells (BMMNCs) transplantation on reendothelialization and neointima formation in vein grafts. Methods: BMMNCs were extracted from the bone marrows of adult rabbit under sterile environment and were labelled with DAPI before transplanted into vein grafts. Twenty adult rabbits were randomly divided into 2 groups: BMMNCs transplantation group(groupⅠ,n=10) and PBS transplantation group (group Ⅱ, n=10). The left external jugular vein of 20 rabbits were harvested and transplanted between ipsolateral common carotid artery(AVG). Three days later, animals in group Ⅰ were transplanted with BMMNCs(6?108 cells)/100 ?l via periotic veins and those in groupⅡwere injected with 100 ?l PBS. Animals were killed 4 weeks later and graft veins were harvested to observe the reendothelialization and the thickness of vein grafts. Results: We found that the transplanted cells survived and were incorporated into the endothelium of vein grafts in groupⅠ.The endothelium integrity of the vein grafts in groupⅠwas significantly better than that of groupⅡ. The intima thickness of vein grafts in groupⅠwas significantly thicker than that of groupⅡ. Conclusion: BMMCs transplantation therapy may improve reendothelialization of the vein graft and inhibits intimal hyperplasi the vein graft.