Hyperpolarization-activated cyclic nucleotide (HCN)-gated channels belong to a nonselective ion channel family,which are common in neurocyte and cardiac muscle cell.These channels play important roles in the nervous system because of their characterstics of hyperpolarization activation.Many studies have shown that HCN channels play key point in excitatory synaptic transmission and integration of output signal.With the development of research,more evidences have been found to prove that the motor learning is damaged and spatial learning ability is enhanced in HCN1 knockout mice.There are two potential mechanisms leading to these changes,one is the lack of HCN1 in cerebellum cell,and the other is the lack of HCN1 in trisynaptic circuits of hippocampus.

Accidents, Occupational ; prevention & control ; Adolescent ; Dermatitis, Occupational ; etiology ; prevention & control ; Female ; Humans ; Male ; Trichloroethylene ; poisoning ; Young Adult

Gastrointestinal Diseases ; Gastrointestinal Motility ; Humans ; Research ; trends

ObjectiveTo explore the influence of cognitive behavioral intervention on hospitalized patients with schizophrenia.Methods100 hospitalized schizophrenia patients were randomly divided into experimental group and the control group.Routine treatment given to the patients in the control group and cognitive behavioral intervention was applied to the patients at the same time based on routine treatment in experimental group.The patients were assessed with the mini-mental state examination( MMSE),activities of daily living(ADL) and WHO battery of cognitive assessment instrument(WHO-BCAI) pre-and post-cognitive behavioral intervention.ResultsThe expenrentcl geoup and ntrol group before and after the intervention the average MMSE score was(21.8 ± 3.9),(24.4 ± 4.7 ),(21.5 ±3.4),(22.9 ±3.8) ;ADL score an average of(28.8 ±7.9),(25.1 ±4.5),(27.9 ±7.1),(25.2 ±4.8) (t =6.89,11.13,all P ＜ 0.05 ) ; cognitive function in the auditory vocabulary learning,language skills,visual identification,the connection test and cancellation tests were different ( P ＜ 0.05 or P ＜ 0.01 ).ConclusionCognitive behavioral intervention had positive influence on cognitive function in hospitalized patients with schizophrenia.

Child ; Diagnosis, Differential ; Gastrointestinal Diseases ; diagnosis ; etiology ; physiopathology ; therapy ; Gastrointestinal Tract ; physiopathology ; Health Knowledge, Attitudes, Practice ; Humans ; Pediatrics ; Prognosis

Objective To in ve stigate quantitatively the expression of pituitary transcription activator (Pit) -1 mRNA in different types of human pituitary adenomas by RT-PCR. Methods Samples were obtained from 35 patients who had unde rgone therapeutic surgery for pituitary adenomas. The type of pituitary adenomas was determined according to serum hormone levels and clinical features, and the grade and the stage of pituitary adenomas were depended on imaging and operatio n observation. Expression of Pit-1 mRNA of pituitary adenomas was assayed by RT -PCR. Results Thirty five patients with pituit ary adenomas consisted of 13 cases with PRL adenomas, 6 cases with GH adenomas, 2 cases with GH/PRL mixed adenomas, 11 cases with clinically non-functioning ad enomas and 3 cases of ACTH adenomas. Pit-1 mRNA was expressed in all PRL, GH an d GH-PRL mixed adenomas and in some non-functioning adenomas (9/11). No Pit-1 mRNA expression was found in ACTH adenomas. Pit-1 mRNA levels in PRL, GH or GH /PRL mixed adenomas were similar and all higher than that in non-functioning ad enomas (all P

Objective To detect the expression of pituitary tumor transforming gene (PTTG) in estrogen-induced rat prolactinoma and various types of human pituitary adenomas to explore the role of PTTG in pituitary tumor oncogenesis. Methods Rat model of estrogen-induced prolactinoma was set up, and PTTG mRNA level in rat prolactinoma was measured by RT-PCR. The expression levels of PTTG and bFGF mRNA in 32 cases of human pituitary adenomas were measured by RT-PCR as well. Results The expression level of PTTG mRNA in rat prolactinoma was obviously higher than that in control pituitary tissue(P

This paper discusses how to teach students to master the basic and important knowledge and to know the development of imageology and simultaneously to cultivate students' innovation consciousness and practice ability in the limited teaching time.

Acute Kidney Injury ; etiology ; pathology ; therapy ; Anti-Bacterial Agents ; administration & dosage ; therapeutic use ; Anticoagulants ; administration & dosage ; therapeutic use ; Child ; Child, Preschool ; Consensus ; Female ; Hemofiltration ; instrumentation ; methods ; Humans ; Infant ; Intensive Care Units, Pediatric ; Male ; Multiple Organ Failure ; etiology ; pathology ; therapy ; Practice Guidelines as Topic ; Sepsis ; complications ; pathology ; therapy ; Severity of Illness Index

Adaptive Immunity ; Bacterial Infections ; immunology ; prevention & control ; Biological Evolution ; Epithelial Cells ; immunology ; Gastrointestinal Diseases ; immunology ; prevention & control ; Humans ; Immunity, Innate ; Lymphocytes ; immunology ; Mucous Membrane ; cytology ; immunology ; Receptors, Pattern Recognition ; immunology ; Toll-Like Receptors ; immunology