1.Successful Treatment of Sclerosing Panniculitis with Danazol.
Sin Wook CHUN ; Sang Yoon LEE ; Hyun Ok SON ; Suk Young LEE ; Byung In RO ; Han Gyu CHOI ; Han Kyoung CHO
Korean Journal of Dermatology 2015;53(1):84-85
No abstract available.
Danazol*
;
Panniculitis*
2.The Effect of Lovastatin(Mevacor(R)) in Patients with Hypercholesterolemia.
Su Young LEE ; Chun Suk KYOUNG ; Dong Chan KIM ; Kye Heui LEE ; Sang Joon CHOI ; In SON ; Seong Hoon PARK
Korean Circulation Journal 1991;21(2):328-336
Lovastatin is a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, which catalyzes the conversion of hydroxymethylglutaryl-coenzyme A to mevalonate, anearly and rate-limiting step in the synthesis of cholesterol. We studied the therapeutic effect and safety of lovastatin in 18 patients with nonfamilial primary hypercholesterolemia. Patients received 20mg/day lovastatin therapy as a single evening dose. If the total cholesterol level exceeded 200mg/dl after 2weeks of lovastatin therapy, the dosage of lovastatin was doubled. Mean percent total cholesterol level reductions from baseline were 26.4% and 31.9% after 4, and 8 weeks of lovastatin therapy respectively. Mean percent HDL-cholesterol level increase from baseline were 12% and 13% after 4, and 8 weeks of lovastatin therapy respectively. Adverse effects attributable to lovastatin were mild and temporary and no patient was withdrawn from therapy. We concluded that lovastatin was a well tolerated and effective agent for the treatment of nonfamilial primary hypercholesterolemia. Further studies are needed to establish the long-term safety and effectiveness of this drug.
Cholesterol
;
Coenzyme A
;
Humans
;
Hypercholesterolemia*
;
Lovastatin
;
Mevalonic Acid
;
Oxidoreductases
3.A Case of Corpus Callosum Agenesis with Ileal Atresia and Duplication.
Kyoung A CHUN ; Young Dae HAM ; Jin Hwa JEONG ; Jeong Ho LEE ; Hye Suk KIM
Journal of the Korean Pediatric Society 2000;43(8):1127-1131
Agenesis of corpus callosum occurs sporadically and may be transmitted as sex-linked, or autosomal-dominant or recessive traits. It has been associated with different syndromes. Clinical pictures vary from severe intellectual and neurologic abnormalities to asymptomatic and normaly intelligent cases. Agenesis of corpus callosum may occur alone, but it is more frequently associated with a high incidence of other anomalies. We report a male infant with agenesis of corpus callosum who was diagnosed to have ileal atresia and duplication.
Agenesis of Corpus Callosum*
;
Corpus Callosum*
;
Humans
;
Incidence
;
Infant
;
Male
4.A Case of Multiple Pseudorheumatoid Nodules.
Sin Wook CHUN ; Hyun Ok SON ; Suk Young LEE ; Jong Baik KIM ; Byung In RO ; Han Gyu CHOI ; Han Kyoung CHO
Korean Journal of Dermatology 2016;54(6):485-486
No abstract available.
Granuloma Annulare
;
Rheumatoid Nodule
5.A Case of Multiple Pseudorheumatoid Nodules.
Sin Wook CHUN ; Hyun Ok SON ; Suk Young LEE ; Jong Baik KIM ; Byung In RO ; Han Gyu CHOI ; Han Kyoung CHO
Korean Journal of Dermatology 2016;54(6):485-486
No abstract available.
Granuloma Annulare
;
Rheumatoid Nodule
6.Blue-gray Pigmentation Induced by Chlorpromazine.
Sin Wook CHUN ; Sang Yoon LEE ; Hyun Ok SON ; Suk Young LEE ; Han Kyoung CHO ; Byung In RO ; Han Gyu CHOI
Korean Journal of Dermatology 2015;53(8):659-661
No abstract available.
Chlorpromazine*
;
Hyperpigmentation
;
Pigmentation*
7.A Case of Cutaneous Focal Mucinosis on the Fingertip.
Sin Wook CHUN ; Hyun Ok SON ; Suk Young LEE ; Jong Baik KIM ; Byung In RO ; Han Gyu CHOI ; Han Kyoung CHO
Korean Journal of Dermatology 2016;54(7):571-572
No abstract available.
Mucinoses*
8.A Case of Segmental Neurofibromatosis with Acrochordon-like Clinical Manifestation.
Sin Wook CHUN ; Hyun Ok SON ; Suk Young LEE ; Jong Baik KIM ; Byung In RO ; Han Gyu CHOI ; Han Kyoung CHO
Korean Journal of Dermatology 2016;54(3):218-220
No abstract available.
Neurofibromatoses*
9.Diagnostic Performance of the Antifilaggrin Antibody in Rheumatoid Arthritis.
Suk Woo CHOI ; Mi Kyoung LIM ; Dong Hyuk SHEEN ; Chun Hwa IHM ; Seung Cheol SHIM
Journal of Laboratory Medicine and Quality Assurance 2003;25(1):181-188
BACKGROUNDS: Rheumatoid factor (RF) is common serological marker for the diagnosis of rheumatoid arthritis (RA), but its sensitivity and specificity are not satisfactory for the diagnosis of RA. Therefore, we investigated the diagnostic performance of a new antifilaggrin antibody test by enzyme linked immunosorbent assay (ELISA) in RA. METHODS: Recombinant human filaggrin was deiminated in vitro by peptidylarginine deiminase and used as the coating antigen for ELISA. We performed the RF and the antifilaggrin antibody for 324 RA patients, 251 non-RA patients (rheumatic diseases other than RA), and 286 normal individuals and evaluated the sensitivities and specificities of RF and antifilaggrin antibody. Optimal cut off values were calculated as mean+2SD in 95% confidence interval except 3SD for 286 normal individuals. Optimal cut off values of antifilaggrin antibody and RF were 9.6 U/ml and 12 U/ml, respectively. RESULTS: The sensitivities and specificities of antifilaggrin antibody were 44.8% and 89.2% at optimal cut off values. The sensitivity and specificity of RF were 75.0% and 83.3%. Combination of "antifilaggrin antibody and RF" showed significantly high specificity of 95.2% and that of "antifilaggrin antibody or RF" showed slightly high sensitivity of 79.3% at optimal cut off values. Antifilaggrin antibody was positive in 17.3% among 81 sero-negative RA patients. CONCLUSION: We considered that antifilaggrin antibody could be used a supplementary test of RF for the diagnosis of RA, because "antifilaggrin antibody and RF" had higher diagnostic specificity than RF alone and antifilaggrin antibody test was easy, convenient ELISA method in performance.
Arthritis, Rheumatoid*
;
Diagnosis
;
Enzyme-Linked Immunosorbent Assay
;
Humans
;
Rheumatoid Factor
;
Sensitivity and Specificity
10.Diagnostic Performance of the Anti-Cyclic Citrullinated Peptide Antibodies in Rheumatoid Arthritis.
Suk Woo CHOI ; Mi Kyoung LIM ; Dong Hyuk SHEEN ; Chun Hwa IHM ; Seung Cheol SHIM
The Korean Journal of Laboratory Medicine 2003;23(2):132-138
BACKGROUND: The Rheumatoid Factor (RF) is the only serological marker in the diagnosis of rheumatoid arthritis (RA), but its sensitivity and specificity are not satisfactory for the diagnosis of RA. Therefore, we investigated the diagnostic performance of a new anti-cyclic citrullinated peptide antibodies test (anti-CCP) by the enzyme-linked immunosorbent assay (ELISA) in RA. METHODS: A cyclic peptide variant that contains citrulline was used as an antigenic substrate in ELISA. We performed the RF and anti-CCP in 324 RA patients, 251 non-RA patients (rheumatic diseases other than RA), and 286 normal individuals. Diagnostic performances such as sensitivity and specificity were evaluated by the receiver-operator characteristics (ROC) curve at optimal cut-off values. The optimal cut-off values were determined at the maximal point of the area under the curve. RESULTS: The sensitivity and specificity of anti-CCP were 72.8% and 92% at 3.8 U/mL. The sensitivity and specificity of RF were 80.6% and 78.5% at 9 U/mL. The sensitivity and specificity of anti-CCP and RF were 67%, 95.2% and 63.3%, 90% at 8.4 U/mL, 20 U/mL, respectively. A combination of anti-CCP with RF increased the sensitivity and specificity to 79.3%, 96.4%, respectively. Anti-CCP was positive in 23.8% among 63 sero-negative RA patients. CONCLUSIONS: We considered that the anti-CCP might be useful as another new serological marker for the diagnosis of a RA combination with RF, or not, because the anti-CCP has a higher diagnostic specificity than the RF and was an easy, convenient ELISA method in performance.
Antibodies*
;
Arthritis, Rheumatoid*
;
Citrulline
;
Diagnosis
;
Enzyme-Linked Immunosorbent Assay
;
Humans
;
Rheumatoid Factor
;
Sensitivity and Specificity