1.The Klippel-Trenaunay syndrome: case report.
Myung Sik PARK ; Chun Su PARK ; Seung Hwan LEE
The Journal of the Korean Orthopaedic Association 1991;26(4):1350-1353
No abstract available.
Klippel-Trenaunay-Weber Syndrome*
2.Systemic Scleroderma in Childhood.
Wook Hwa PARK ; Tae Hyun PARK ; Kyung Deuk PARK ; Dong Sik BANG ; Soo Il CHUN
Korean Journal of Dermatology 1995;33(1):183-187
The onset of systemic scleroderma in the first. decade of lif occurs in less than 1.5% of instances. Systemic sclerodrma in childhood have been characterized by less severe visceral involvement and a benign course We report a boy, aged 7 years, with a history of Raynaid; phenomenon and dysphagia. He had a mask-like face, flexion contracture of hands and knee joints, digital pitting scars, ichthyosiform skin change on leg and hyperpigrnented induration on all extremities and trunk. Antinuclear antibodies were positive in nucleolar type and Scl-70 antiocy was also present. On radiologie study, the pattern of reflux esophagitis and resorption of the listal ends of all phalanges were nated. Histopathological findings were compatible with sclerodma. He was treated with Penicillamine-D and oral corticosteroic with good improvernent.
Antibodies, Antinuclear
;
Cicatrix
;
Contracture
;
Deglutition Disorders
;
Esophagitis, Peptic
;
Extremities
;
Hand
;
Humans
;
Knee Joint
;
Leg
;
Male
;
Scleroderma, Systemic*
;
Skin
3.Histiocytosis X Case Report.
Chun Sik CHOI ; Kyong Sik PARK ; Ki Yong PARK ; Mun Bae JU
Journal of Korean Neurosurgical Society 1981;10(1):341-346
Eosinophilic granuloma, Hand-Schuller-Christian and Abt-Letterer-Siewe syndrome are known to be the same disease entity involving the reticulohistiocytic system of the body, although their clinical manifestations are different. So they were included under the term of Histiocytosis X and this concept has been generally accepted. The authors have experienced one case of Hand-Schuller-Christian disease and that of eosinophilic granuloma. The former was a 23 years old man with complaints of exophthalmos, polyuria and a tender palpable mass on the right parietal area and in the latter a soft pulastile mase located on the left parietal area in a 3 year old boy. There was no neurological deficits on their admission. We managed them with radiation and steroid therapy following surgical curettage.
Child, Preschool
;
Curettage
;
Eosinophilic Granuloma
;
Exophthalmos
;
Histiocytosis*
;
Histiocytosis, Langerhans-Cell*
;
Humans
;
Male
;
Polyuria
;
Rabeprazole
;
Young Adult
4.Embryonic Developmental Capacity and Pregnancy Rates of Fertilized Oocytes in IVF, ICSI and TESE-ICSI Cycles.
Kee Sang PARK ; Yoon Kyu PARK ; Hai Bum SONG ; Taek Hoo LEE ; Sang Sik CHUN
Korean Journal of Fertility and Sterility 2004;31(3):169-176
OBJECTIVE: This study was performed to evaluate and compare the embryonic developmental capacity and pregnancy rates in conventional in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) with ejaculated sperm or testicular sperm cycles. MATERIALS AND METHODS: Fertilization was examined in the following morning after IVF (group I), ICSI (group II) or TESE-ICSI cycles (group III). Fertilized oocytes were co-cultured with Vero cells until embryo transfer (ET). On day 2 and 5~7, grades of embryos (<4- or > or =4-cell) and blastocysts (BG1, 2, 3 or early) were evaluated. Clinical pregnancy rate was determined by detecting G-sac with transvaginal ultrasonogram. We analyzed the results bychi2 and Student's t-test and considered statistically significant when P value was less than 0.05. RESULTS: Fertilization rate was significantly higher (p<0.05) in group I (79.0+/-21.2%) than in group II and III (56.8+/-21.6% and 36.7+/-25.3%). Cleavage and blastulation rate of group I (95.8+/-13.8% and 59.5+/-25.3%) were significantly higher (p<0.05) than those of group III (83.4+/-18.6% and 40.4+/- 36.5%). Clinical pregnancy rate was significantly higher (p<0.05) in group I and II (40.7% and 41.7%) than that in group III (12.5%). No differences were found in the rates of multiple pregnancy and abortion among three groups. Embryonic implantation rate was higher in group I (15.1+/-20.2%, p<0.05) and II (14.7+/-20.6%, NS) than that in group III (5.1+/-15.6%). However, embryonic implantation rate was increased in ET with blastocyst(s) among three groups. CONCLUSIONS: Fertilized oocytes obtained from TESE-ICSI were harder to be successfully cultured to blastocyst stage for 5~7 days than that from IVF cycles. However, all blastocyst(s) ET increased the embryonic implantation rate equally in IVF, ICSI and TESE-ICSI cycles.
Blastocyst
;
Embryo Transfer
;
Embryonic Development*
;
Embryonic Structures
;
Female
;
Fertilization
;
Fertilization in Vitro
;
Oocytes*
;
Pregnancy
;
Pregnancy Rate*
;
Pregnancy*
;
Pregnancy, Multiple
;
Sperm Injections, Intracytoplasmic*
;
Spermatozoa
;
Ultrasonography
;
Vero Cells
5.A Study on the Therapeutic Shoes for Diabetic Patients.
Journal of Korean Foot and Ankle Society 2004;8(1):16-21
PURPOSE: To investigate the characteristics of the patients and therapeutic shoes for diabetic patients. MATERIALS AND METHODS: Forty two diabetic patients who had their own therapeutic shoes which were prescribed somewhere else were studied from March 2003 to December 2003. There were 27 males and 15 females, and the mean age was 62.1 years (range, 49-72 years). Duration of diabetes was average 14 years (range, 6~30 years), all had type 2 diabetes. Sensation was examined with 5.07 nylon monofilament. The route of purchasing the shoes, compliance to the prescribed shoes were investigated by interview. The shape of shoe, stiffness of upper, conformity of insole to the shape of the foot were recorded. In-shoe plantar pressure was measured in 15 patients. RESULTS: Eighteen patients were insensate to the monofilament. Seven patients did not wear the therapeutic shoes, and only 18 of 35 patients were wearing the therapeutic shoes more than 6 hours a day. The shoes of 17 patients were prescribed by medical doctor and the rest were purchased by the recommendation of acquaintances or advertisement. Ulcer recurred in four of five patients to whom the shoe was prescribed by medical doctor and the cause of three recurrences were evident by just observing the foot and shoe. The therapeutic shoes were made from 11 different makers. Eight shoes were adequate for diabetic patients with respect to the material, shape of insole, type of shoe. In-shoe plantar pressure was examined in 15 patients and was less than 300 kPa in all patients. CONCLUSION: The therapeutic shoes for the diabetic patients need to be prescribed by medical doctor for selective patients with neuropathy or previous history of ulcer and follow-up examination is important to monitor the compliance of the patients and adequacy of the shoes.
Compliance
;
Female
;
Foot
;
Friends
;
Humans
;
Male
;
Nylons
;
Recurrence
;
Sensation
;
Shoes*
;
Ulcer
6.Subsequent Embryo Transfers (SET) on Day 2 and 5: It's Safety and Effectiveness.
Taek Hoo LEE ; Sang Sik CHUN ; Kee Sang PARK ; Hai Bum SONG
Korean Journal of Fertility and Sterility 2000;27(2):165-172
OBJECTIVE: In vitro fertilization (IVF) and a prolonging the time of culture may be helpful in establishing a viable pregnancy through a selection effect. Some embryos do not develop beyond the 4-cell stage and some may not develop to the blastocyst stage. We have evaluated the safety of SET and the outcomes of pregnancy. METHODS: Sperms were treated with Ham's F-10 supplemented with 10% human follicular fluid (hFF). Oocytes or fertilized oocytes were cultured in Dulbecco's Modified Eagle Medium (DMEM) with 10% or 20% hFF respectively. Up to five oocytes were inseminated with approximately 200,000 sperm cells/2 ml in each well. Fertilization was examined in the following morning and fertilized oocytes were co-cultured until embryo transfer. Vero cells for co-culture were prepared in Tissue Culture Medium - 199 (TCM-199) with 10% fetal bovine serum. At the two to four cell and blastocyst on day 2 and day 5, embryo and blastocyst grading were evaluated. Pregnancy rate was determined after transfer of human embryos at the two to four cell stage on day 2 (Group I) or subsequent transfer of embryos on day 2 and at the blastocyst stage on day 5 (Group II). For statistically significant when rho value was less than 0.05. RESULTS: No differences was found in the fertilization between Group I(81.0%, 98/121) and Group II(81.8%, 180/220). In case of cleavage rate, no difference was found in Group I(95.9%, 94/98) and Group II(66.7%, 12/18) than in Group (26.3%, 5/19). CONCLUSION: The results of this study showed that SET is safe and effective, and significantly increases the pregnancy rate.
Blastocyst
;
Coculture Techniques
;
Eagles
;
Embryo Transfer*
;
Embryonic Structures*
;
Female
;
Fertilization
;
Fertilization in Vitro
;
Follicular Fluid
;
Humans
;
Oocytes
;
Pregnancy
;
Pregnancy Rate
;
Spermatozoa
;
Vero Cells
7.The Effects of Oocyte Preparation on the Developing Capacity of Human Oocytesat Intracytoplasmic Sperm Injection (ICSI).
Kee Sang PARK ; Taek Hoo LEE ; Hai Bum SONG ; Sang Sik CHUN
Korean Journal of Fertility and Sterility 1999;26(3):399-406
OBJECTIVE: In the preparation of ICSI, cumulus and corona cells should be removed from the oocytes by using a combination of enzymatic (hyaluronidase) and mechanical (pipetting) methods. But little is known about the effects of different degrees of oocyte denudation and incubation time between denudation and sperm injection on the outcomes of ICSI. The aim of this study was to evaluate the effects of varying the degrees of oocyte denudation and the lengths of incubation time from denudation to sperm injection on the outcomes of ICSI. METHODS: In experiment 1, patients (oocytes) were grouped into group A and B according to the degree of denudation, complete and partial, respectively. In experiment 2, patients (oocytes) were grouped into group I, II and III according to the length of incubation time of denuded oocytes until sperm injection as < 1, 1~2 and >2 hours, respectively. RESULTS: There was no significant difference between the degree of oocyte denudation on the survival, fertilization and development rates after ICSI procedure. In case of the incubation time of denuded oocytes until ICSI, survival rates was higher in group III (83.1%) than in group I (61.5%, p<0.05) or group II (64.3%). However no statistically significant differences were found between incubation time and fertilization or development rates. CONCLUSIONS: This study reveals that the outcomes of ICSI are not affected by the degree (complete or partial) of oocyte denudation. However the denuded oocytes with incubation period of more than 2 hours show better outcomes of ICSI than those with the incubation period of less than 2 hours.
Fertilization
;
Humans*
;
Oocytes*
;
Sperm Injections, Intracytoplasmic*
;
Spermatozoa
;
Survival Rate
9.Genetics of Branchal Asthma.
Tuberculosis and Respiratory Diseases 2006;60(4):391-396
10.Tufted Angioma:Clinicopathologic Surveys and the Response to Intralesional Steroid.
Dong Hyun KIM ; Sung Nam CHANG ; Soo Il CHUN ; Dong Sik BANG ; Wook Hwa PARK
Annals of Dermatology 2002;14(1):22-27
BACKGROUND: Tufted angioma is an uncommon slowly progressive vascular tumor found typically in infants and young children with characteristic histologic findings, so called "cannonball" appearance. OBJECTIVE: The purpose of this study was aimed to investigate the clinical and histopathological characteristics of tufted angioma and the response to intralesional steroid. METHODS: Clinical information of 10 patients with tufted angioma diagnosed in Severance hospital and Pundang CHA hospital from 1983 to 1999 was obtained from the medical records and clinical follow-ups. We re-evaluated 10 biopsy specimens obtained from them with routine H&E staining. RESULTS: Five male and five female patients were included. In 9 patients the lesion appeared before 2 months of age. Four had a lesion at birth. The thigh was the most common site. The clinical symptoms were diverse, but characteristically tenderness was present in most cases. In all the patients the lesions had a tendency to spread progressively. Microscopically, numerous, distinct, variably sized, tightly packed capillary and endothelial cellular lobules were scattered in the dermis. There were characteristic semilunar spaces adjacent to the capillary tufts. Six patients received intralesional triamcinolone. This treatment was found to be effective in 5 patients who experienced remarkable improvement. The improved cases had similar histologic findings which were composed of cellular mass more than lumen formation. We classified our specimens into two categories, one with more cellular mass and the other with more lumen formation in relative proportion. The former was different from the latter in that it had more solid appearance and more definite margin. And we realized that it was useful to divide into these two categories since its response to treatment could be different. CONCLUSIONS: Tufted angioma is a relatively uncommon disease with characteristic histopathologic findings. It seems not to regress spontaneously. So early treatment is required to pre-vent further spreading up to the extent. We treated 6 patients with intralesional injection of triamcinolone and 5 patients experienced marked improvement which had more cellular mass more than lumen formation histopathologically.
Biopsy
;
Capillaries
;
Child
;
Dermis
;
Female
;
Follow-Up Studies
;
Hemangioma
;
Humans
;
Infant
;
Injections, Intralesional
;
Male
;
Medical Records
;
Parturition
;
Thigh
;
Triamcinolone