In order to evaluate the effect of zinc sulfate on acne vulgaris, this study was performed during 3 months' period from October, 1979 to December 31, 1979. Total number of acne patients visited at the Department of Dermatology, Han Gang Sung Shim Hospital were 130, but among them 58 patients had completed this atudy. The patients were classified in 3 groups, A, B, C, as follows. Group A (23 patients) who were treated with zinc sulfate (600mg/day) and 2. 5% benzoyl peroxide Group B (20 patients) who were treated with tetracycline (initial: 750mg/day, after 2weeks: 500rng/day) and 2. 5% benzoyl peroxide. Group C (15 patients) who were treated with only 2. 5% benzoyl peroxide. To evaluate the efficacy of treatment in these 3 groups, the number of open comedone, closed comedone, papule and pustule were counted every other week for 8 weeks. (countiuned..)
Acne Vulgaris ; Benzoyl Peroxide ; Dermatology ; Humans ; Tetracycline ; Zinc Sulfate* ; Zinc*

No abstract available.
Olecranon Process* ; Ulna*

We report two cases of hyperlipoproteinernia(HLP) with various cutaneous xanthomas. Case 1 was a 12-year-old girl, who had tuberous, tendinous, and plane cutaneous xanthomas and corneal arcus of the left eye. Case 2 was a 40-year-old man, who had tuberous, eruptive, and plane cutaneous xanthomas. Serum lipid and lipoprotein analysis reveoled patterns of Type IIa HLP in case 1 and, of Type IIb HLP, in case 2. They have been treated with diet control and hypolipidemic drugs and are under our continuing medical supervision.
Adult ; Child ; Female ; Humans ; Hyperlipoproteinemia Type II/diagnosis* ; Hyperlipoproteinemia Type II/drug therapy* ; Hypolipidemic Agents/therapeutic use* ; Lipoproteins ; Man ; Xanthomatosis/diagnosis ; Xanthomatosis/drug therapy

PURPOSE: To evaluate the treatment results and prognostic factors after radiotherapy in stage IIB uterine cervix cancer. MATERIALS AND METHODS: We retrospectively analyzed the records of 90 patients with stage IIB uterine cervix cancer who received radiotherapy between 9/94 and 12/99. Age was ranged from 28 to 79 years (median 57). Tumor size was > or = 4 cm in 64 patients. Preteatment SCC level was measured in 76 patients. Twenty nine patients received conventional radiotherapy (QD) and the others received modified hyperfractionated radiotherapy (BID). Only 7 patients in BID had tumor size <4 cm. All patients received high dose rate brachytherapy (4 Gy x 7 or 5 Gy x 6). No patient received concurrent chemotherapy during radiotherapy. Follow up period was ranging from 9 to 76 months (median 38). RESULTS: The 5-year overall and disease free survival rates were 73.4% and 71.6%, respectively. Local recurrences occurred in 10% of patients, and distant metastasis in 18.9%. There was a significant correlation between OS/DFS and tumor size (<4 cm; OS 95.2%, DFS 91.4%, > or = 4 cm; OS 63.4%, DFS 63.4%). Pretreatment SCC level was one of prognostic factors only in univariate analysis. CONCLUSION: With modified hyperfractionated radiotherapy, there was very low local recurrence rate (6.6%) and high 5-year overall and disease free survival rate (75.4% and 70.5%), which is comparable to results after concurrent chemoradiotherapy in bulky, locally advanced stage IIB uterine cervix cancer.
Brachytherapy ; Cervix Uteri* ; Chemoradiotherapy ; Disease-Free Survival ; Drug Therapy ; Female ; Follow-Up Studies ; Humans ; Neoplasm Metastasis ; Radiotherapy* ; Recurrence ; Retrospective Studies

No abstract available.
Chylous Ascites*

No abstract available.
Animals ; Mice*

BACKGROUND: Angiogenesis is crucial for many biological processes such as embryogenesis, cyclic changes in the endometrium and wound healing. It is also critical for the growth, invasion and metastasis of solid tumors. Vascular endothelial growth factor (VEGF) acts as a mitogen for endothelial cells and is expressed by the presence of various tumor cells. The objective of this study is to evaluate if angiogenesis is involved in the mouse skin carcinogenesis and if VEGF is related to angiogenesis. METHODS: We induced premalignant and malignant lesions on mouse (BALB/c) skin using the two stage chemical carcinogenesis moedl, DMBA (7,12-dimethylbenzanthracene) initiation and TPA (tetra decanoyl-phorbol-acetate) promotion. And we analysed the microvessel densities (MVD) and expression of VEGF in various stages of premalignant and malignant lesions by immunohistochemical studies. RESULTS: Squamous papillomas, keratoacanthoma, dermatofibroma, and squamous cell carcinomas were developed in 20 weeks. There were no differences in the incidence of benign and malignant tumors between 10-week and 20-week promotion groups. There were significant increases in MVD from normal and hyperplastic skin through premalignant lesion to invasive squamous cell carcinoma (p<0.0005). But the degree of VEGF expression neither correlated with neither MVD nor the tumor groups. CONCLUSIONS: Increased angiogenesis begins from the hyperplastic stage. VEGF produced by tumor cells may not play major roles in the angiogenesis in the two stage chemical carcinogenesis model of the mouse skin.
9,10-Dimethyl-1,2-benzanthracene ; Animals ; Biological Processes ; Carcinogenesis* ; Carcinoma, Squamous Cell ; Embryonic Development ; Endometrium ; Endothelial Cells ; Female ; Histiocytoma, Benign Fibrous ; Incidence ; Keratoacanthoma ; Mice* ; Microvessels ; Neoplasm Metastasis ; Papilloma ; Pregnancy ; Skin* ; Vascular Endothelial Growth Factor A* ; Wound Healing

PURPOSE: To report a patient with isolated congenital absence of the right inferior rectus muscle. To our knowledge, this is the first case reported in Korea. METHODS: A 6-year-old girl presented with an anomalous head posture of 15 degrees head tilt. She had 45delta right hypertropia, 15delta A-pattern exotropia and a marked underaction of the right inferior rectus. At the time of the surgery, forced duction test of the right eye showed no limitation and the inferior rectus muscle was found to be absent. Inferior transposition of the horizontal rectus muscles was more approximated to each other than that described in the classic Knapp operation. This was carried out while the right medial rectus muscle was simultaneously resected 2mm for correction of the exotropia. RESULTS There was significant improvement in infraduction at 6 months postoperative with only a residual 6delta exotropia in primary position. CONCLUSIONS: Absence of the inferior rectus showed hypertropia with A pattern exotropia. It did not bring about contracture of the superior rectus muscle or amblyopia. The outcome of the modified Knapp procedure was satisfactory.
Amblyopia ; Child ; Contracture ; Exotropia ; Female ; Head ; Humans ; Korea ; Muscles ; Posture ; Strabismus

PURPOSE: To report a patient with isolated congenital absence of the right inferior rectus muscle. To our knowledge, this is the first case reported in Korea. METHODS: A 6-year-old girl presented with an anomalous head posture of 15 degrees head tilt. She had 45delta right hypertropia, 15delta A-pattern exotropia and a marked underaction of the right inferior rectus. At the time of the surgery, forced duction test of the right eye showed no limitation and the inferior rectus muscle was found to be absent. Inferior transposition of the horizontal rectus muscles was more approximated to each other than that described in the classic Knapp operation. This was carried out while the right medial rectus muscle was simultaneously resected 2mm for correction of the exotropia. RESULTS There was significant improvement in infraduction at 6 months postoperative with only a residual 6delta exotropia in primary position. CONCLUSIONS: Absence of the inferior rectus showed hypertropia with A pattern exotropia. It did not bring about contracture of the superior rectus muscle or amblyopia. The outcome of the modified Knapp procedure was satisfactory.
Amblyopia ; Child ; Contracture ; Exotropia ; Female ; Head ; Humans ; Korea ; Muscles ; Posture ; Strabismus

It is commonly believed that the branchial anomalies are persistent remnants of the embryologic branchial apparatus. These anomalies are originated from branchial cleft and most commonly involved in second branchial deft. Clinically they present palpable mass, discharge from fistula, recurrent infection due to obstruction of Gstula tract. As respiratory symptoms, they may present hoarseness, preceeded by or associated with upper respiratory infection. However, it has not been reported that they caused airway obstruction in newborn infants. Wc experienced a case of the fourth branchial deft cyst in a 2 day old infant who showed respiratory difficulty due to airway obstruction.
Airway Obstruction ; Branchial Region* ; Branchioma* ; Fistula ; Hoarseness ; Humans ; Infant ; Infant, Newborn