We report a case of hereditary trichilemmal cyst with proliferating trichilemmal tumor in a 64-year-oid man, who has generalized 157, variable sized firm cutaneous nodules for 40 years. The cystic nodules are chiefly located on the scalp and trunk which showed characteristic histopathologieal findings of trichilemmal cyst and proliferating trichilemmal tumors. His son also has multiple trichilemmal cysts and his mother seems to have had clinically similar lesions. The patient and his son were treated with surgical excision and therapeutic trial of oral isotretinoin for 2 months. Isotretionoin was ineffective in the patient, but the lesions of his son were decreased in size.
Humans ; Isotretinoin ; Mothers ; Scalp

The clinical and mycological investigation was made with 68 cases of tinea corporis who had visited the Dermatologic Clinic of N.M.C. from Nov. 1985 to Oct. 1988. The results were as follows : 1. The ratio of male to female was 1.1: 1, and tinea corporis was most preva lent in the twenties. 2. 25 cases (36.8%) had a history of contact with infected animals or soil. 3. 75% of cases had less than 2 lesions. The exposed area was more frequently affected, and the face being the most frequent site. 4, Concurrent infection of tinea corporis with other types of dermatophytosis were noted in 33 cases (48.8%), and the most common was tinea pedis. 5. From the 68 cases, 49 organisms composed of 4 species were isolated, which were T. rubrum (32 cases), M. Canis (11 cases), T. mentagrophytes (5 cases) and M. gypseem (1 case). 6. Of the clinical variants of tinea corporis, the annular type was most comm only noted. No species specificity was noted in annular type, but T. rubrum was the major causative organism of eczematous and plaque type, and M. canis was the only isolated organism in herpetiform type. 7. As compared with other dermatophytes, M. canis was more commonly isolated from the smaller lesion.
Animals ; Arthrodermataceae ; Female ; Humans ; Male ; Soil ; Species Specificity ; Tinea Pedis ; Tinea*

No abstract available.
Granuloma* ; Leprosy, Lepromatous*

We report, a 1-day-old male with congenital cutaneous candidiasis who had generalized erythematous papules and pustules on the whole body including palms and soles from birth. At 5th month of pregnancy, his mother had a history of vaginal candidiasis for a month KOH mount of pus from pustules of several different sites showed budding spores and pseudohrphae and fungus culture revealed the growth of Candida albicans We believe this to he the first documented case of congenital cutaneous candidiasis in Korean literature.
Candida albicans ; Candidiasis ; Candidiasis, Cutaneous* ; Fungi ; Humans ; Male ; Mothers ; Parturition ; Pregnancy ; Spores ; Suppuration

We describe a case of typical cytophagic histiocytic panniculitis occuring in 10-year-old male. He had recurrent subcutaneous nodules, fever, pancytopenia and abnormal liver function tests since 5 months of his age, and recently showed hemorrhagic diathesis. The histologic picture showed lobular histiocytic panniculitis with "bean bag" cytophagic cells.
Child ; Fever ; Hemorrhagic Disorders ; Humans ; Liver Function Tests ; Male ; Pancytopenia ; Panniculitis*

BACKGROUND: It has been well known that patients with diabetes mellitus are prone to cutaneous infections, but whether superficial mycoses are truly more prevalent in diabetic patients is still controversial. OBJECTIVE: The purpose of this study was to determine the true prevalence of superficial mycoses in diabetic patients as comparing with non-diabetic, non-immunocompromised individuals. METHODS: We examined for evidence of superficial fungal disease in 137 diabetic patients and compared it with 146 non-diabetic non-immunocompromised ones. Potassium hydroxide preparations and fungus cultures were performed from all suspected lesions. RESULTS: Superficial mycoses were more common in diabetic patients(50%) than controls(31%) (p=0.0004), especially in the age group of 4th and 5th decades9p=0.011). The duration of diabetes mallitus or blood sugar levels were not significantly correlated with the prevalence of superficial mycoses.The organism most commonly isolated was Trichophyton rubrum in both groups(53% vs 79%) and Candida albicans was more prevalent in diabetic patients(34% vs 7%). More than 2 kinds of superficial mycoses were mose common in diabetic patients than controls(38% vs 16%). CONCLUSION: This study shows that the prevalence rate of superficial mycoses in diabetic patients is higher than that in controls and the in controls and the duration of diabetes mellitus or blood sugar levels were not significantly correlated with it.
Blood Glucose ; Candida albicans ; Diabetes Mellitus ; Fungi ; Humans ; Mycoses* ; Potassium ; Prevalence ; Trichophyton

Brain metastases are a common cause of disability and death in patients with cancer, but their management remains a major clinical problem. They can, however, be effectively controlled by radiation therapy, possible modalities being external radiotherapy, brachytherapy(implantation), stereotactic radiosurgery(SRS), or a combination of the above modalities. It can be expected that the neurologic status of patients thus treated will remain stable or improve for most of the period during which they survive; using whole brain radiotherapy, the possible palliation index is 75-80%. Despite treatment, however, as many as 1/3 to 2/3 of patients are expected to die from complications related to the progression of brain metastases. With regard to survival, randomized trials involving dose escalation have not yet shown any advantage over the conventional dose; the same palliation index of 75-80% is expected for 40Gy/20 fractions, 30Gy/10 fractions, and 20Gy/5 fractions. It is clear, however, that a smaller daily dose of radiation(the conventional dose is 200cGy/fraction) will reduce the incidence of radiation induced dementia and improve the quality of life in long term survivors. In certain conditions such as solitary brain metastasis without extracranial disease and good performance status(KPS>or=70), a more aggressive approach, including surgical resection and stereotactic radiosurgery can be considered.
Brachytherapy ; Brain* ; Dementia ; Humans ; Incidence ; Neoplasm Metastasis* ; Quality of Life ; Radiosurgery ; Radiotherapy ; Survivors

No abstract available.
Skin*

No abstract available.
Compliance* ; Rehabilitation*

BACKGROUND: An epidemiologic study was performed after the outbreak of carbapenem-resistant Acinetobacter baumannii (CRAB) in the medical intensive care unit (MICU) from December 2006 to May 2007. METHODS: A retrospective case-control study was performed using the medical records of the patients. The case and control patients were compared for age, gender, total length of stay in MICU, prior carbapenem use, Acute Physiology and Chronic Health Evaluation II (APACH II) score, presence of central line, effect of mechanical ventilation, and sputum suction. Environmental and hand-washing studies were performed during the outbreak. RESULTS: Ten CRAB-affected patients and 29 controls were enrolled in this study. Univariate analysis showed that the age, total length of stay in MICU, presence of central line, and prior carbapenem use were associated with the CRAB outbreak. However, multivariate analysis showed that only prior carbapenem use was associated with the CRAB outbreak (odd ratio: 8.67, P=0.01). The outbreak disappeared after implementing a combined infection control strategy, including the sequential disinfection of MICU and strict compliance with cross-transmission prevention protocols. CONCLUSION: The use of carbapenem was associated with an increased risk of CRAB infection. This study suggests that the MICU contamination and infection transmission by health-care workers played a major role in the CRAB outbreak. Novel strategies such as restricted use of broad-spectrum antibiotics, strict hand hygiene, strict isolation of the patients, and MICU disinfection may be required to prevent the CRAB outbreak.
Acinetobacter ; Acinetobacter baumannii ; Anti-Bacterial Agents ; APACHE ; Case-Control Studies ; Compliance ; Disease Transmission, Infectious ; Disinfection ; Epidemiologic Studies ; Hand Hygiene ; Humans ; Infection Control ; Critical Care ; Intensive Care Units ; Length of Stay ; Medical Records ; Multivariate Analysis ; Respiration, Artificial ; Retrospective Studies ; Risk Factors ; Sputum ; Suction