1.Clincal Features of Methemoglobinemia in Newborn Diarrhea Infant.
Hyun Geun KIM ; Chun Soo KIM ; Sang Lak LEE
Journal of the Korean Society of Neonatology 1997;4(2):238-245
PURPOSE: Newborn infants with diarrhea, metabolic acidosis and dehydration may develop methemoglobinemia without exposure to oxidizing agents. This study was undertaken to investigate clinical features in the development of methemoglobinemia in newborn infants with diarrhea. METHOD: This study involved 16 newborn infants with diarrhea who were admitted to NICU at Dong San Medical Center between January 1995 and June 1996. We investigated the age of onset of methemoglobinemia, sex ratio, level of methemoglobin in the blood, feeding methods, clinical manifestations, arterial blood gas findings, the results of culture findings and the response to therapy. RESULT: 1) The age of onset was beyond the second week of life in most cases, no sex predilection was noted and formula feeding was used in all cases. 2) Methemoglobin level in the blood was 10.1-20.0% in 7 cases, 20.1-30.0% in 6 cases, 30.1-40.0% in 2 cases and above 40.1% in one case. 3) Clinical rnanifestations on admission: moderate to severe dehydration developed in all patients with diarrhea along with respiratory distress in 13 cases, cyanosis in 6 cases, fever was noted in 5 cases, vomiting in 5 cases, while 2 cases presented with abdominal distention. Combined diseases included metabolic acidosis in most cases (93.8%), hypokalemia in 6, failure to thrive in 3, chronic diarrhea in 2, hyponatremia in 2, necrotizing enterocolitis in 1 and hepatitis was found in one case. 4) In all cases, there were no pathogenic organisms found in either blood or urine cultures along with similar negative findings in stool cultures, and Rotazyme test results using ELISA method were negative. 5) Rehydration and correction of acidosis with sodium bicarbonate was accomplished in all patients and 11 cases with greater than 15% methemoglobin were treated with methylene blue, 2mg/kg as a 1% solution in normal saline. Response to methylene blue was indicated in 1 to 2 hours in all cases although there was a reoccurrence of methemoglobinemia after an initial response in 2 cases, they both responded favorably with retreatment with methylene blue. CONCLUSION: In all newborn infant with diarrhea, dehydration and metabolic acidosis, screening tests for early diagnosis of methemoglobinemia should be considered with prompt fluid replacement therapy.
Acidosis
;
Age of Onset
;
Cyanosis
;
Dehydration
;
Diarrhea*
;
Early Diagnosis
;
Enterocolitis, Necrotizing
;
Enzyme-Linked Immunosorbent Assay
;
Failure to Thrive
;
Feeding Methods
;
Fever
;
Fluid Therapy
;
Hepatitis
;
Humans
;
Hypokalemia
;
Hyponatremia
;
Infant*
;
Infant, Newborn*
;
Mass Screening
;
Methemoglobin
;
Methemoglobinemia*
;
Methylene Blue
;
Oxidants
;
Retreatment
;
Sex Ratio
;
Sodium Bicarbonate
;
Vomiting
2.A study of peripheral blood eosinophil and serum IgE level in patients with atopic dermatitis.
Dong Geun KANG ; Chun Wook PARK ; Cheol Heon LEE
Korean Journal of Dermatology 1992;30(1):51-56
The peripheral blood eosinophil and serum IgE level in 53 patients with atopic dermatitis (AD) were measured. The patients were divided into 2 groups by severity(mild and severe grous) and into 3 groups by the associated respiratory atopic deseases and/or their family history : respiratory group(patient, with both AD and respiratory atopy), family history group (patient with both AD and family history of respiratory atopy), and atopic group(patient with neither respiratory atopy nor family history of respiratorv atopy). We designed to study which factors are important in the elevation of serum IgE and peripheral blood eosinophil level in AD, and to know possible relationships between the serum eosinophil and IgE level and the several groups of AD. The results are as follows : 1. Peripheral eosinophil counts were higher in severe group(224.8/mm) than in mild group (180.0/mm)(p<0.05). 2. Peripheral eosinophil counts were 220.0/mm in atopic group, l65.0/mm in family history group, and 332.4/mm in respiratory group, but there was no stitistically significant difference among 3 groups. This suggests that concomitant respiatitiry atopy or a family history of respiratory atopy is not an important factor in the elvation of peripheral blood eosinophil counts in AD. 3. Serum IgE was higher in severe group(443.2IU/ml) than in mild group(231.5IU/ml)(p<0.05). 4. Serum IgE level in respiratory group(754.6IU/ml) were signifiiantlly higher than in atopic (286.6IU/ml) or family history group(342.0IU/ml)(p<0,01). But there was no significant. difference between family and atopic group. This result suggests that concomittent respiratory atopy is a potential factor in elevation of serurn Igi in AD. 5. Slightly high correlation between peripheral blood and IgE level appeared in all 53 patients (r=0.434) and severe group(r=0.480). But, respiratory group(r=0.060), family history group(r=0.111) and atopic group(r=0.202) showed poor relationships.
Dermatitis, Atopic*
;
Eosinophils*
;
Humans
;
Immunoglobulin E*
3.Linear Sebaceous Hyperplasia.
Dong Geun KANG ; Chun Wook PARK ; Cheol Heon LEE
Annals of Dermatology 1992;4(1):45-48
We report an unusual case of sebaceous hyperplasia in an 18-year-old male manifestated clinically as yellowish, grouped papules with a linear distribution, present on the right side of forehead since birth. Histopathologically, a large sebaceous gland composed of numerous lobules grouped around a centrally dilated duct was seen. The sebaceous lobules distributed in the upper dermis showed direct connection to the skin surface, which suggested a transepidermal elimination of sebaceous lobules.
Adolescent
;
Dermis
;
Forehead
;
Humans
;
Hyperplasia*
;
Male
;
Parturition
;
Sebaceous Glands
;
Skin
4.Detection of the c-m c Oncogene Amplification in Ovarian Carcinomas by Differential Polymerase Chain Reaction.
Geun Shin LYU ; Chan Kum PARK ; Chun Geun LEE ; Youl Hee CHO ; Youn Yeoung HWANG ; Jung Dal LEE
Korean Journal of Pathology 1997;31(7):644-654
The amplification of c-myc oncogene was evaluated in 42 cases of ovarian carcinomas to correlate with clinical parameters. Using oligonucleotide primers, sequences from the c-myc exon-3 gene and from a control gene, tissue plasminogen activator (tPA), were amplified simultaneously by polymerase chain reaction (PCR). After the products of differential PCR (d-PCR) were electrophoresed, slot blot hybridization was performed, and hybridized with P32 dATP-labeled myc and tPA oligonucleotide probes and then autoradiographed. The signal intensities of the two products were quantitated by densitometry and the ratios of two products (c-myc/tPA) were measured. The ovarian carcinomas showed significantly increased amplification of c-myc oncogene Oligonucleoti compared to normal control group (p<0.05). 15 of 42 cases (35.7%) showed various degrees of the MYC gene amplification up to 27 folds in various histologic types of ovarian carcinomas. No significant differences of the MYC gene amplification according to histologic subtypes, tumor action) grades and clinical stages of ovarian carcinomas were present.
Densitometry
;
DNA Primers
;
Genes, myc
;
Oligonucleotide Probes
;
Oncogenes*
;
Polymerase Chain Reaction*
;
Tissue Plasminogen Activator
5.CT Findings of Breast Lipoma: A Case Report.
Kyung Joo PARK ; Moon Ok LEE ; Chun Hwan HAN ; Jeong Geun YI ; Joo Hyuk LEE
Journal of the Korean Radiological Society 1994;30(3):589-590
Lipoma is one of the unusual benign breast neoplasms and usually manifests at fatty breast of women at the age of 40 to 60. We experienced a case of large breast lipoma nearly replacing the whole left breast parenchymal tissue with mammographic finding of well-defined radiolucent mass, sonographic finding of hyperechoic mass with disorganized echopattern and computerized tomographic finding of very low attenuation mass, characteristic to adipose tissue, in a young woman of her dense breast.
Adipose Tissue
;
Breast Neoplasms
;
Breast*
;
Female
;
Humans
;
Lipoma*
;
Ultrasonography
6.Island flaps of the hand.
Geun Jik LEE ; Jong Moon LEE ; Seung Ha PARK ; Woo Kyung KIM ; Chun Eun CHUNG
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1993;20(5):1125-1135
No abstract available.
Hand*
;
Surgical Flaps*
7.Radiologic Findings of Male Breast Cancer: A Case Report.
Kyung Joo PARK ; Chun Hwan HAN ; Jeong Geun YI ; Joo Hyuk LEE
Journal of the Korean Radiological Society 1994;31(4):759-761
Male Breast cancer is an uncommon disease with an incidence of I per cent of all breast cancers. Male breast cancer usually appears as a small mass with well-defined contour which is eccentrically located in relation to the nipple on mammogram. We report a case of breast cancer in a 51-year-old man with mammographic appearance of large hyperdense mass with nipple inversion and axillary lymphadenopathy, gray-scale sonographic finding of homogeneous solid mass and mu Itiple tumor vessels with in the mass on color Doppler ultrasound.
Breast
;
Breast Neoplasms
;
Breast Neoplasms, Male*
;
Humans
;
Incidence
;
Lymphatic Diseases
;
Male
;
Male*
;
Middle Aged
;
Nipples
;
Ultrasonography
8.Prenatal imaging of thanatophoric dysplasia: a case report.
Jeong Geun YI ; Mie Young KIM ; Kyung Joo PARK ; Chun Hwan HAN ; Joo Hyuk LEE
Journal of the Korean Radiological Society 1993;29(6):1337-1340
Thanatophoric dysplasia is the most common lethal congenital chondrodysplasia with characteristic features of narrow thorax, short rib, severe platyspondyly, short bowed limbs and skull deformity, etc. It is not a hereditary disorder and there is usually no family history of dysplasia. We experienced a case of thanatophoric dysplasia at 38 weeks of gestation with antenatal sonographic and abdominal radiographic findings of small thorax, short bowed extremities with surrounding thickened soft tissues and marked platyspondyly. Soon atter delivery, the baby died and post-mortem radiographs showed the characteristic findings of thanatophoric dysplasia.
Congenital Abnormalities
;
Extremities
;
Humans
;
Pregnancy
;
Ribs
;
Skull
;
Thanatophoric Dysplasia*
;
Thorax
;
Ultrasonography
9.A case of right pulmonary artery arising from ascending aorta.
Chun Uhng JOO ; Nam Ki KIM ; Ja Hong KUH ; Doing Geun LEE
Journal of the Korean Pediatric Society 1992;35(9):1303-1306
No abstract available.
Aorta*
;
Pulmonary Artery*
10.The Effect of Caudal Block with Morphine Sulfate on Postoperative Pain Levels in Lumbar Spinal Surgery.
Seung Hwan YOUN ; Hyoung Chun PARK ; Eun Young KIM ; Byung Yun CHUN ; Hong Sik LEE ; Sung Geun LEE
Journal of Korean Neurosurgical Society 1997;26(6):808-813
In 38 of 70 patients who underwent lumbar spinal surgery, we performed a randomized, prospective double-blind study of the effect of caudal block with morphine sulfate on postoperative pain levels. Age, sex, clinical features, postoperative analgesic consumption, pain score, adverse effects and patient satisfaction on discharge were recorded. The consumption of parenteral analgesics on the 1st, 2nd and 3rd days was significantly lower in the morphine sulfate group(p<0.05), than in the control group. Caudal block with morphine sulfate also led to marked reductions in pain levels and thus increases patients satisfaction during the postoperative period(p<0.05). Transient respiratory depression occurred in three of 38 patients(7.9%), but further treatment was not needed. Seventeen patients(44.7%) developed urinary retention, but this recovered spontaneously. The present study demonstrates that caudal block with morphine sulfate leads to a highly significant reduction in pain during postoperative periods and a corresponding reduction in the need for additional postoperative analgesics, in addition, patients are more satisfied.
Analgesics
;
Double-Blind Method
;
Humans
;
Morphine*
;
Pain, Postoperative*
;
Patient Satisfaction
;
Postoperative Period
;
Prospective Studies
;
Respiratory Insufficiency
;
Urinary Retention