Cell Proliferation ; Child ; Humans ; Nervous System Diseases ; surgery ; Neurons ; transplantation ; Stem Cell Transplantation ; adverse effects ; methods ; trends

Child ; China ; Critical Illness ; Humans ; Intensive Care Units, Pediatric ; Pediatrics

China ; Intensive Care Units, Neonatal ; organization & administration

Female ; Humans ; Infant, Newborn ; Infant, Newborn, Diseases ; etiology ; genetics ; Maternal-Fetal Relations

China ; Humans ; Pediatrics ; trends

Brain Death ; diagnosis ; Breath Tests ; Cerebrovascular Circulation ; Child ; Child, Preschool ; Coma ; diagnosis ; Electroencephalography ; Humans ; Infant ; Infant, Newborn ; Neurologic Examination ; Practice Guidelines as Topic

Acute Kidney Injury ; etiology ; pathology ; therapy ; Anti-Bacterial Agents ; administration & dosage ; therapeutic use ; Anticoagulants ; administration & dosage ; therapeutic use ; Child ; Child, Preschool ; Consensus ; Female ; Hemofiltration ; instrumentation ; methods ; Humans ; Infant ; Intensive Care Units, Pediatric ; Male ; Multiple Organ Failure ; etiology ; pathology ; therapy ; Practice Guidelines as Topic ; Sepsis ; complications ; pathology ; therapy ; Severity of Illness Index

Objective: To observe the recent efficacy, long-term survival and the side effects of low energy ultrasonic cavitation in treatment of 53 patients with solid tumors. Methods: Fifty-three patients with solid tumors were randomly divided into three groups: group A (18 patients received low energy ultrasonic cavitation therapy combined with chemotherapy), group B (18 patients received chemotherapy alone) and group C (17 patients received low energy ultrasonic cavitation therapy alone). Low energy ultrasonic cavitation therapy was administrated five days in one week for 2 weeks or three times each week for 3 weeks. Results: All fifty-three patients were included in the analysis. In group A, one case achieved complete response (CR), 6 cases achieved partial response (PR) and 9 cases achieved stable disease (SD); the disease control rate (CR+PR+SD) was 88.61% (16/18). In group B, no cases achieved CR, 4 cases achieved PR and 7 cases achieved SD; the disease control rate was 61.11% (11/18). In group C, no cases achieved CR, 4 cases achieved PR and 6 cases achieved SD; the disease control rate was 58.82% (10/17). The difference of disease control rate between groups A and B was significant (P<0.05). One-year survival rates of these three groups were 66.67%, 44.44% and 41.18%, respectively, and two-year survival rates were 38.89%, 16.67% and 17.65%, respectively. The one- and two-year survival rates in group A were both higher than those in group B and group C (P<0.05), but the difference was not observed between group B and group C. The proportions of patients with improved quality of life in groups A, B and C were 83.33%, 55.56% and 58.82%, respectively. There was no blood toxicity in group C. The major toxicities were local pain and fever, which could be self-relieved. Conclusion: Low energy ultrasonic cavitation therapy in treatment of solid tumors is efficient and well-tolerated, and the quality.

OBJECTIVE: To analyze recent studies on the role of the endocannabinoid system in liver disease and related mechanism. METHODS: Reading domestic and international documents in recent years, we concluded a comprehensive integrated about them. RESULTS: This paper reviews the important role of the endocannabinoid in the development of liver disease, which focuses on the prevention and protection of the endocannabinoid on viral hepatitis, alcoholic fatty liver disease, non-alcoholic fatty liver disease, cholestatic liver disease and liver ischemia-reperfusion injury and the development of hepatic fibrosis and hepatic encephalopathy. CONCLUSION: Endocannabinoid system plays an important role in the treatment of liver disease. But for its complex mechanism of action, we need further research.