Annular erythema associated with lupus erythematosus/ Sjogrens syndrome has recently been described in Orientals. We present a patient with recurrent annular erythema who partially demonstrated features of lupus erythematosus. A 32-year-old man was referred to us for recurrent annular erythema. Laboratory findings revealed mild leukopenia and the presence of antinuclear antibodies at a titer of 320 with a finely speckled pattern on Hep-2 substrates. Anti-Ro/La antibodies were also detected. A skin biopsy specimen revealed the findings of perivascular and periappendageal lymphocytic infiltration without prominent hydropic degeneration of the basal layer. Skin lesions subsided with hydroxychloroquine (400-200mg/day).
Adult ; Antibodies ; Antibodies, Antinuclear ; Biopsy ; Erythema* ; Humans ; Hydroxychloroquine ; Leukopenia ; Sjogren's Syndrome ; Skin

No abstract available.
Humans ; Stroke*

Carcinoid-type tumorlets of the lung are nodular microscopic proliferation of round and spindle-shaped small cells which originated from bronchial or bronchiolar Kulchitsky-type neuroendocrine cells, which are usually encountered as an incidental finding during microscopic examination of the lungs at autopsy or surgically removed for bronchiectasis or other reasons. We report one case of carcinoid-type tumorlets in the lung which was surgically removed from a patient who had bronchiectasis, and the cells of tumorlets showed immunohistochemical reactivities for markers of epithelial and neuroendocrine differentiation.
Autopsy ; Bronchiectasis ; Humans ; Incidental Findings ; Lung* ; Neuroendocrine Cells

No abstract available.
Oxygen*

BACKGROUND: Ultraviolet(UV) light is one of the injurious environmental agents which is known to lead to apoptosis of cells. However, studies on UVB-induced apoptosis of melanocytes are still lacking and there are some discrepancies between researchers. OBJECTIVE: Our purpose was to evaluate the characteristics of UVB-induced apoptosis of melanocytes and G361 cells. METHODS: Cultured normal human melanocytes and malignant melanoma cell lines (G361 cells) were analyzed by several detection methods including morphological examination of propidium iodide(PI) stained cells under fluorescence microscopy, quantitation of fragmented DNA, and flow cytometric analysis. RESULTS: Both melanocytes and G361 cells showed similar rate of apoptosis with gradual increment of UVB doses by the quantitation of fragmented DNA. However, flow cytometric analysis using scatter properties and PI stainability revealed that the melanocytes were more resistant to UVB than G361 cells. CONCLUSION: We suggest that melanocytes seem to be more resistant to UVB-induced injury than G361 cells. In addition, various methods for the detection of apoptosis might be necessary for its study. (Ann Dermatol 10:(3) 147152, 1998).
Apoptosis* ; Cell Line ; DNA ; Humans* ; Melanocytes* ; Melanoma ; Microscopy, Fluorescence ; Propidium

No abstract available.
Pulmonary Alveolar Proteinosis*

BACKGROUND: Hemoptysis always merits thorough investigation because even minimal bleeding may be an early indicator of the presence of significant bronchopulmonary disease. But in patients with hemoptysis & a normal chest roentgenogram, there are no clear guidelines for a diagnostic approach, including the indications of bronchoscopy. METHODS: Eighty patients with hemoptysis and a normal chest roentgenogram were involved in this study. We evaluated the cause of hemoptysis in these patients by bronchoscopy and/or bron- chogram or high-resolution CT of the lung and we analyzed the relationship of clinical features, such as age, sex, smoking and properties of hemoptysis, to the cause of hemoptysis. RESULTS: 1) They were 34 men and 46 women, with the mean age of 46.7 and 41.8 years old, respectively. 2) Initial bronchoscopy provided a diagnosis in 8 patients - bronchogenic carcinoma in 3 patients (3.8%), metastatic cancer in 1 patient(1.3%) and endobronchial tuberculosis in 4 patients(5.0%). 3) Two clinical findings of patients over 50 years and/or with more than 30 pack-year smoking history were associated with bronchogenic carcinoma, and among these two factors, a more than 30 pack-year smoking history was the best predictor for diagnosis of bronchogenic cancer. 4) The 72 patients in whom no specific cause of hemoptysis was identified by initial bronchoscopy underwent bronchogram and/or high resolutional CT of the lung. Then, 6 patients were diagnosed as bronchiectasis and 5 patients rebleeded in the follow up period of 9 to 90 weeks. Of the remaining 66 patients, 33 were followed for 7 to 80 weeks. Among these patients, only 5 patients had recurrent episodes of hemoptysis &A they were diagnosed as bronchiectasis in 1 patient, tuberculosis in 2 patients and catamenial hemoptysis in 2 patients. CONCLUSION: We conclude that patients with hemoptysis and a normal chest roentgenogram who are more than 50 years old or have more than 30 pack-year smoking history should undergo bronchoscopy to exclude possible bronchogenic carcinoma. In patients without these clinical features, a conservative approach with observation appears justified. If hemoptysis recurs to these patients, bronchogram or high-resolutional CT of the lung with sputum examination are necessary.
Bronchiectasis ; Bronchoscopy ; Carcinoma, Bronchogenic ; Diagnosis ; Female ; Follow-Up Studies ; Hemoptysis* ; Hemorrhage ; Humans ; Lung ; Male ; Smoke ; Smoking ; Sputum ; Thorax* ; Tuberculosis

No abstract available.
Catheters* ; Drainage* ; Lung Abscess* ; Lung*

The purpose of the present study was to evaluate cardiovascular regulation during passive standing (PS) after ethanol ingestion by spectral analysis of heart rate variability (HRV) in flushed and nonflushed subjects. Of 24 young male subjects, 8 belonged to flushed group (F) and 16 to nonflushed group (NF). Two sessions of 10-min PS were performed before and after ethanol (0.5 g/kg) ingestion. Powers of R-R interval variability in very low frequency (VLF, 0~0.05 Hz), low frequency (LF, 0.05~0.15 Hz) and high frequency (HF, 0.15~0.50 Hz) bands, normalized powers (LFn and HFn) and LF/HF ratio were obtained. After ethanol ingestion, F showed higher heart rate than NF. PS increased LFn (+ 22.9+/-3.6 in NF, + 12.8+/-4.7 in F, in normalized units) and LF/HF (+ 3.10+/-0.57 in NF, + 3.00+/-1.08 in F) and decreased HFn powers. Ethanol ingestion increased LFn and LF/HF and decreased HFn. PS after ethanol resulted in higher LFn and LF/HF and lower HFn than the prior PS. F showed a greater and more sustained HRV change than NF after ethanol. In conclusion, PS or ethanol ingestion increased LFn and LF/HF and decreased HFn. Flushed subjects showed an accentuated HRV response to ethanol.
Arterial Pressure ; Dizziness ; Eating* ; Ethanol* ; Flushing ; Heart Rate* ; Heart* ; Humans ; Male

OBJECTIVES: To identify and compare the health behaviors and health status of the elderly between urban and rural areas using the data of the Korean National Health and Nutrition Examination Survey (KNHANES). METHODS: The study population comprised 3,823 elderly people aged 65 years or older who participated in the 4th KNHANES (2007-2009). The areas were classified into "large cities," "cities," and "rural areas" using the administrative and residential areas. The health behaviors and health status of the elderly between the rural and urban areas were compared using a complex sample design with the Rao-Scott chi-square test and weighted multiple logistic regression analysis. RESULTS: Compared to large cities, the odds ratios (ORs) (95% confidence interval [CI]) of rural areas were as high as 1.58 (1.25-2.01) for the influenza vaccination and as low as 0.47 (0.37-0.59) for flexibility exercises, 0.56 (0.38-0.81) for muscular exercises, and 0.76 (0.62-0.92) for obesity. The ORs (CI) for osteoarthritis and diabetes mellitus were as low as 0.81 (0.66-0.99) and 0.70 (0.55-0.89), respectively. CONCLUSIONS: The health behaviors and health status of the elderly are better in rural areas than in urban areas despite the fact that the socioeconomic conditions in rural areas are poorer that those in urban areas. These findings suggest that programs suitable for residential areas should be developed and that studies to explain the differences in residential areas are needed.
Aged* ; Diabetes Mellitus ; Electrolytes ; Exercise ; Health Behavior* ; Humans ; Influenza, Human ; Logistic Models ; Nutrition Surveys ; Obesity ; Odds Ratio ; Osteoarthritis ; Pliability ; Vaccination