The extent of brain damage is known to be an essential predictive factor in the clinical course of patient with severe head injury. The purpose of the work was to study the usefulness of brain type creatine kinase(CK-BB) as a iochemical index of brain injury. We performed a Tri-check isoenzyme electrophoresis to determine the serum level of CK-BB in 123 patients with head injury. CK-BB isoenzyme was detected in the serum in 24 out of 123 patients with acute brain injury(19.5%). The peak of CK-BB activity ranged from 2 to 85IU/1 and mean value was 21.40+/-21.66IU/1. The activity was higher in patients with diffuse axonal injury, intracerebral hematoma and subdural hematoma than any other cases. The serum CK-BB isoenzyme was more frequently detected in low GCS score cases at admission and these patients had poor outcome than high GCS score cases. High CK-BB activity in serum was associated with poor prognosis, but a low CK-BB activity in serum was not necessarily a good prognostic sign. The presence of the serum CK-BB isoenzyme correlated with admission GCS score and with the ultimate outcome. We conclude that CK-BB level in serum is a reliable marker of cerebral parenchymal injury and may enhance the predictive value of the Glasgow coma scale score when used in conjunction with this indicant.
Brain ; Brain Injuries ; Craniocerebral Trauma* ; Creatine Kinase* ; Creatine* ; Diffuse Axonal Injury ; Electrophoresis ; Glasgow Coma Scale ; Head* ; Hematoma ; Hematoma, Subdural ; Humans ; Prognosis

The extent of brain damage is known to be an essential predictive factor in the clinical course of patient with severe head injury. The purpose of the work was to study the usefulness of brain type creatine kinase(CK-BB) as a iochemical index of brain injury. We performed a Tri-check isoenzyme electrophoresis to determine the serum level of CK-BB in 123 patients with head injury. CK-BB isoenzyme was detected in the serum in 24 out of 123 patients with acute brain injury(19.5%). The peak of CK-BB activity ranged from 2 to 85IU/1 and mean value was 21.40+/-21.66IU/1. The activity was higher in patients with diffuse axonal injury, intracerebral hematoma and subdural hematoma than any other cases. The serum CK-BB isoenzyme was more frequently detected in low GCS score cases at admission and these patients had poor outcome than high GCS score cases. High CK-BB activity in serum was associated with poor prognosis, but a low CK-BB activity in serum was not necessarily a good prognostic sign. The presence of the serum CK-BB isoenzyme correlated with admission GCS score and with the ultimate outcome. We conclude that CK-BB level in serum is a reliable marker of cerebral parenchymal injury and may enhance the predictive value of the Glasgow coma scale score when used in conjunction with this indicant.
Brain ; Brain Injuries ; Craniocerebral Trauma* ; Creatine Kinase* ; Creatine* ; Diffuse Axonal Injury ; Electrophoresis ; Glasgow Coma Scale ; Head* ; Hematoma ; Hematoma, Subdural ; Humans ; Prognosis

No abstract available.
Chylothorax* ; Lymphangiectasis*

No abstract available.
Thyroid Gland* ; Thyroid Nodule*

No abstract available.
Odontogenic Cyst, Calcifying* ; Odontoma*

No abstract available.
Odontogenic Cyst, Calcifying* ; Odontoma*

No abstract available.
Amniotic Fluid* ; Female ; Humans*

The authors analyzed ultrasonographically the total 45 cases of thyroid disease verified by historicaldiagnosis, functional diagnosis, and morphological diagnosis at the Departement of Radiology, Busan NationalUniversity hospital from June to Sept. 1982. The resuls obtained were as follows; 1. In the sex distributionfemale was 38 cases (84.4%), and male 7 cases (15.6%). 2. Among the total 4 cases thyroid adenoma was 24 cases(53.3%), nodular hyperplasia 8 cases (17.7%), thyroid carcinoma 7 cases (15.6%), diffuse hyperplasia 3 cases(6.7%), Hanshimoto's thyroiditis 1 cases (2.2%), subacute thyroiditis 1 cases(2.2%), tuberculous thyroiditis 1cases(2.2%) in orders. 3. On ultrasonogram, total 24 cases of thyroid adenoma showed a single nodule in 24 cases(100.0%), smooth outer margin in 23 cases (95.8%), capsular echo in 23 cases (95.8%), pure cystic nodule in 4cases (16.7%), and increased echogenicity in 17 cases (85.0%) among the 20 cases excluded the pure cystic nodules.4. Total 7 cases of thyroid carcinoma showed no capsular echo in 4 cases (57.1%), irregular outer margine in 4cases(57.1%), no pure cytic nodule in all cases, and enlargement of metastatic lymphnode in 4 cases (57.1%). 5.Total 8 cases of nodular hyperplasia showed enlargement of thyroid gland and multiple nodule in 8 cases (100.0%),and increased echogenicity in 7 cases (87.5%). 6. Total 3 cases of diffuse hyperplasia showed enlargement ofthyroid gland and increased echogenicity in 3 cases (100.0%). 7. Total 3 cases of thyroiditis showed decreasedechogenicity in 3 cases (100.0%) and enlargement of thyroid gland in 2 cases (66.7%). 8. The cold area visualizedon radionuclide scan could be differentiated from a solid mass and cystic one by utrasonogram.
Busan ; Diagnosis ; Humans ; Hyperplasia ; Male ; Thyroid Diseases ; Thyroid Gland ; Thyroid Neoplasms ; Thyroiditis ; Thyroiditis, Subacute ; Ultrasonography

Silicone gel breast implants may induce local(fibrous capsular contracture) or systemic(rheumatoid arthritis, systemic sclerosis, etc) complications. The exact mechanism of fibrous capsular contracture has not been fully understood. In the present study, we tried to find out the effect of silicone gel on the fibroblast proliferation which has been known as a major contributing factor in fibrous capsular contracture formation. In vitro, activated macrophages are known to secrete monokines which affect fibroblast proliferation and collagen synthesis. And tumour necrosis factor-alpha(TNF-alpha) and interleukin-6(IL-6), which were released by macrophages, were reported as potent stimulator of fibroblast proliferation. The goal of this study is to investigate the role of macrophages and tumour necrosis factor-alphaor interleukin-6 in the interaction of fibroblasts and silicone gel. We designed four groups, two experimental and two control, using Institute for Cancer Research(ICR) mouse peritioneal macrophage and silicone gel. For the preparation of the conditioned medium of macrophages, peritoneal macrophages were prepared and cultured for 24 hours on the silicone gel-coated and naked (not coated) surface [silicone gel-macrophage conditioned medium(SCM; experimental group) and normal polystyrene-macrophage conditioned medium(NCM; control group) respectively]. To correct the effect of 10% fetal bovine serum which was included in Rapid Prototyping and Manufacturing Institute (RPMI) 1640 medium and draw the effect only by macrophages, the RPMI 1640 medium with 10% fetal bovine serum was cultured by the same method on the silicone gel-coated and naked surface (silicone gel-macrophage free conditioned medium; SFM and normal polystyrene-macrophage free conditioned medium; NFM respectively). Each conditioned medium was added onto NIH 3T3 fibroblasts culture at a final 25% concentration of total culture medium and followed by the cultivation for 24 hours. For antibody neutralizing experiments, each conditioned medium was preincubated with polyclonal rabbit anti-mouse TNF-alpha antibody or polyclonal rat anti-mouse IL-6 antibody for 1 hour and then, conditioned medium with antibody was added to the culture medium of NIH 3T3 fibroblasts by the same method. After 24 hours cultivation, total number of viable fibroblast(cell growth), DNA synthesis and collagen synthesis of fibroblasts with each medium were measured by sulforhodamine B(SRB) assay, 3H-thymidine and 3H-proline incorporation respectively. The results were as follows: 1. In the experiment about the effect of the conditioned medium on the fibroblast activity, the experimental group(SCM), compared with the control group(NCM), showed a significant increase of the cell growth (p<0.01), a significant decrease of DNA synthesis(p<0.001), but no significant difference in the collagen synthesis. 2. In the experiment about the effect of polyclonal rabbit anti-mouse TNF-alpha antibody on the fibroblast activity, after the addition of antibody the experimental group, compared with the control group, showed a significant decrease of the cell growth(p<0.001), a significant increase of DNA synthesis(p<0.01), but no significant difference in the collagen syn thesis. 3. In the experiment about the effect of polyclonal rat anti-mouse IL-6 antibody on the fibroblast activity, after the addition of antibody the experimental group, compared with the control group, showed a significant decrease of the cell growth(p<0.001), a significant increase of DNA synthesis(p<0.0001), but no significant difference in the collagen synthesis. In conclusion, culture supernatants (conditioned medium) of peritoneal macrophages, activated by silicone gel, stimulate the NIH 3T3 fibroblast proliferation. TNF-alpha and IL-6, products of macrophage, are involved in the stimulation of NIH 3T3 fibroblast proliferation in an in vitro condition.
Animals ; Arthritis ; Breast Implants ; Collagen ; Contracture ; Culture Media, Conditioned ; DNA ; Fibroblasts* ; Interleukin-6* ; Macrophages ; Macrophages, Peritoneal* ; Mice ; Monokines ; Necrosis ; Rats ; Scleroderma, Systemic ; Silicone Gels* ; Tumor Necrosis Factor-alpha*

A 27-year-old female with low back pain and paresthesia on the left lower extremity had been treated. Lumbar myelography showed total block of the dye column at the L3 vertebral body level with a brush border. After myelography, total laminectomy on the L3 and L4 vertebrae was done. The result of operation and biopsy revealed an extradural meningioma of angioblastic type. 9 days after the surgery all neurological deficits were completely recovered.
Adult ; Biopsy ; Female ; Humans ; Laminectomy ; Low Back Pain ; Lower Extremity ; Meningioma* ; Microvilli ; Myelography ; Paresthesia ; Spine