1.Relation between Beta-2-glycoprotein I and hepatitis B virus surface antigen.
Pujun GAO ; Yanjun GUO ; Like QU ; Tong SHI ; Hongyan ZHANG ; Chun'e DONG ; Hanyi YANG
Chinese Journal of Hepatology 2002;10(1):31-33
OBJECTIVETo clarify the binding character between Beta-2-glycoprotein I (Beta-2-GPI) and HBsAg.
METHODSBeta-2-GPI was purified from human plasma and labelled with biotin. Solid phase enzyme linked absorbance assay was used to investigate its binding with HBsAg.
RESULTSBiotinylated Beta-2-GPI was found to bind HBsAg and the reaction could be inhibited by excess unlabelled Beta-2-GPI.
CONCLUSIONSBeta-2-GPI may play a role in hepatitis B virus infection.
Binding Sites ; Biotinylation ; Enzyme-Linked Immunosorbent Assay ; methods ; Glycoproteins ; isolation & purification ; metabolism ; Hepatitis B Surface Antigens ; metabolism ; Hepatitis B virus ; chemistry ; metabolism ; Humans ; beta 2-Glycoprotein I
Result Analysis
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